Habilitationsschrift--Geschichtswissenschaft--Freiburg i. Br. / Bibliogr. p. 181-192. Index.

Texte remanié de: Thèse de doctorat--Histoire--Paris 4, 1987. Titre de soutenance : L'Orient islamique au début du onzième siècle à travers le "Mirʼāẗ al-zamān", ouvrage de Sibṭ ibn al-Ǧawzī (+654/1256). / Mention parallèle de titre ou de responsabilité : "@Mirʼāẗ al-zamān", li-Sibṭ ibn al-Ǧawzī : li-l-sanawāt 1004-1021. Bibliogr. p. 129-158. Notes bibliogr. Index. IFPO = Institut français du Proche-Orient. PIFD = Publications de l'Institut français de Damas.

Thèse 3e cycle--Hist. de l'art et archéol.--Paris I, 1981. / Bibliogr. p. 153-156.

The ability to sense and respond to external environmental signals is closely regulated by a plurality of cell signaling pathways, thereby maintaining homeostasis. In particular, the inflammatory signaling cascade contributes to cellular homeostasis and regulates responses prompted by external stimuli. Such responses are diverse and range from a variety of processes, including tissue repair, cell fate decisions, and even immune-cell signaling. As with any signaling cascade, strict regulation is required for proper functioning, as abnormalities within the pathway are often associated with pathologic outcomes. A hyperactive inflammatory response within the gastrointestinal tract, for example, contributes to inflammatory bowel disease (IBD), presenting as Crohn’s disease or ulcerative colitis. Furthermore, as a chronic condition, IBD is associated with an increased risk for the development of colitis-associated cancer. In order to resolve inflammation and thus restore homeostasis, negative regulation may be utilized to mediate the activity of inflammatory molecules. The mechanistic action of a specific negative regulator of interest, interleukin receptor associated kinase M (IRAK- M), is explored in detail within the present dissertation. Investigation of IRAK-M in mouse models of colitis, which mimics human IBD, and in mouse models of inflammation-driven tumorigenesis, which models colitis associated cancer, demonstrated that loss of this molecule contributes to host protection. Therefore, IRAK- M may be a suitable target for inhibition in order to advance therapeutic options for human patients afflicted with a GI-related inflammatory disease, such as IBD and colitis associated cancer. Furthermore, an ex vivo method that models the interaction of intestinal epithelial cells with microbes present in the GI tract was optimized and is described in the present dissertation. This method takes advantage of primary intestinal derived organoids, also termed “mini-guts”, which display similar features corresponding to intestinal tissue in vivo. For this reason, the use of “mini-guts” has several advantages, particularly for the enhancement of personalized medicine. The method discussed herein aims to normalize experimental conditions in order to enhance reproducibility, which can further be used to uncover microbial-epithelial interactions that contribute to a pathological state, such as IBD. Finally, this method of intestinal epithelial cell culture was utilized to evaluate the role of a protein, termed NF-κB inducing kinase (NIK), in intestinal epithelial cell growth and proliferation. Ultimately, ex vivo organoid culture can serve as an important model system to study the contribution of NIK in intestinal stem cell renewal, cancer progression, as well as in maintenance of the integrity of the gastrointestinal barrier. / Ph. D. / Inflammation is a tightly regulated physiologic process that is employed by body systems such as the gastrointestinal (GI) tract to handle pathogenic insult, aid in wound healing, and help prevent infections. When abnormal inflammatory responses occur, this can lead to the progression of severe diseases such as ulcerative colitis and Crohn's disease. When inflammation persists in the GI tract, such as in inflammatory bowel disease, this can predispose patients to the development of inflammation- associated colorectal cancer. In order to improve the treatment options for patients afflicted with these maladies, this dissertation is aimed at studying the signaling pathways of the innate immune system that regulate such inflammatory responses. Furthermore, this body of work encompasses a detailed method for isolating and culturing intestinal stem cells, which can be applied in personalized medicine for patients with intestinal diseases. This method was utilized in this dissertation to study genetically modified intestinal stem cells, and can further be used to investigate the interactions of intestinal epithelial cells with pyogenic bacteria that contribute to inflammatory maladies in the GI tract.

Thèse (M.A.) -- Université Laval, 2006. / Bibliogr.: f. [104]-111. Publié aussi en version électronique dans la Collection Mémoires et thèses électroniques.

Thèse (Ph.D.)--Université de Sherbrooke (Canada), 2008. / Titre de l'écran-titre (visionné le 29 sept. 2009). In ProQuest dissertations and theses. Publié aussi en version papier.

Texte remanié de: Ph.D. thesis--Warsaw university. / La p. de titre porte : "Eski Mosul Dam salvage project excavations of the Polish center of archaeology, University of Warsaw" Bibliogr. p. 81-87.

Thesis--Philosophy--University of Birmingham. / Bibliogr. p. 266-277.

Seminario para optar al grado de Licenciado en Comunicación Social / A inicios del año 2003, los ojos del mundo estaban puestos una vez más en el Medio Oriente. Se iniciaba uno de los conflictos con mayor cobertura e impacto periodístico, desde la Guerra del Golfo de 1991, y tenía nuevamente como protagonistas a Estados Unidos, y a uno de los países más ricos del mundo árabe. Se iniciaba así, la llamada Guerra de Irak. El enfrentamiento adquirió una particular relevancia, puesto que involucró a la nación que detenta el mayor poderío militar y económico del planeta, Estados Unidos, y a su aliado de armas, el Reino Unido, quienes desplegaron en la que es considerada cuna de la civilización, un operativo militar nunca antes visto en la historia de la humanidad. El gobierno iraquí, liderado hasta ese momento por el cuestionado Saddam Hussein, era acusado por las naciones aliadas de poseer armas químicas y de destrucción masiva, contraviniendo las restricciones que al respecto le había impuesto la Organización de Naciones Unidas. Esta situación fue considerada una preocupante amenaza para la paz mundial y el mundo occidental, pretexto usado por el gobierno estadounidense para que, pese al rechazo generado en la comunidad internacional, y sin la aprobación del Consejo de Seguridad de la ONU, decidiera lanzar el 27 de marzo de 2003 una incontrarrestable ofensiva bélica sobre Irak.

La investigación que da pie a la presente tesis se origina en un proyecto artístico personal 1 sobre la percepción “diferida” de la guerra a través de las imágenes mediales y su resignificación en la pintura. Posteriormente, una vez en la Maestría de Antropología Visual, mis motivaciones se ampliaron bajo la idea de realizar un documental- ensayo con la utilización de material audiovisual encontrado y alojado en Internet sobre un caso de migración estacional laboral de ciudadanos peruanos, quienes prestaron “servicios de seguridad” en el extranjero (2005-2012) contratados por Compañías Militares Privadas de Seguridad (CMPS), entre ellas, la americana Triple Canopy Co, (Virginia); durante la invasión de Estados Unidos a Irak.