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The Global ETD Search service is a free service for researchers
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 2 of 2 (0.05 seconds)Spelling suggestions: "subject:"JC virus load""
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Chlorpromazine Combined with Cidofovir for Treatment of a Patient Suffering from Progressive Multifocal LeukoencephalopathyPöhlmann, Christoph, Hochauf, Kristina, Röllig, Christoph, Schetelig, Johannes, Wunderlich, Olaf, Bandt, Dirk, Ehninger, Gerhard, Jacobs, Enno, Rohayem, Jacques 18 March 2014 (has links) (PDF)
We report on a stem cell-transplanted patient with B cell chronic lymphatic leukemia who presented with a subacute onset of focal neurological deficits, gait abnormalities, emotional lability and dementia. Progressive multifocal leukoencephalopathy was diagnosed by magnetic resonance imaging (MRI) of the brain and detection of JC virus genome in the cerebrospinal fluid. Cidofovir and the 5HT2A receptor antagonist chlorpromazine were subsequently administered. A follow-up MRI of the brain 2 weeks after initiation of the antiviral therapy displayed progress of the demyelination, and the patient died 3 months after onset of the neurological symptoms. This report highlights the need for the development of novel and potent strategies for treatment of progressive multifocal leukoencephalopathy. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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Chlorpromazine Combined with Cidofovir for Treatment of a Patient Suffering from Progressive Multifocal LeukoencephalopathyPöhlmann, Christoph, Hochauf, Kristina, Röllig, Christoph, Schetelig, Johannes, Wunderlich, Olaf, Bandt, Dirk, Ehninger, Gerhard, Jacobs, Enno, Rohayem, Jacques January 2008 (has links)
We report on a stem cell-transplanted patient with B cell chronic lymphatic leukemia who presented with a subacute onset of focal neurological deficits, gait abnormalities, emotional lability and dementia. Progressive multifocal leukoencephalopathy was diagnosed by magnetic resonance imaging (MRI) of the brain and detection of JC virus genome in the cerebrospinal fluid. Cidofovir and the 5HT2A receptor antagonist chlorpromazine were subsequently administered. A follow-up MRI of the brain 2 weeks after initiation of the antiviral therapy displayed progress of the demyelination, and the patient died 3 months after onset of the neurological symptoms. This report highlights the need for the development of novel and potent strategies for treatment of progressive multifocal leukoencephalopathy. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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