Dissertation thesis deals with development and implementation of Business Intelligence (BI) solutions for Small and Medium Sized Enterprises (SME) in the Czech Republic. This thesis represents climax of author's up to now effort that has been put into completing a methodological model for development of this kind of applications for SMEs using self-owned skills and minimum of external resources and costs. This thesis can be divided into five major parts. First part that describes used technologies is divided into two chapters. First chapter describes contemporary state of Business Intelligence concept and it also contains original taxonomy of Business Intelligence solutions. Second chapter describes two Knowledge Discovery in Databases (KDD) techniques that were used for building those BI solutions that are introduced in case studies. Second part describes the area of Czech SMEs, which is an environment where the thesis was written and which it is meant to contribute to. This environment is represented by one chapter that defines the differences of SMEs against large corporations. Furthermore, there are author's reasons why he is personally focusing on this area explained. Third major part introduces the results of survey that was conducted among Czech SMEs with support of Department of Information Technologies of Faculty of Informatics and Statistics of University of Economics in Prague. This survey had three objectives. First one was to map the readiness of Czech SMEs for BI solutions development and deployment. Second was to determine major problems and consequent decisions of Czech SMEs that could be supported by BI solutions and the third objective was to determine top factors preventing SMEs from developing and deploying BI solutions. Fourth part of the thesis is also the core one. In two chapters there is the original Methodology for development and deployment of BI solutions by SMEs described as well as other methodologies that were studied. Original methodology is partly based on famous CRISP-DM methodology. Finally, last part describes particular company that has become a testing ground for author's theories and that supports his research. In further chapters it introduces case-studies of development and deployment of those BI solutions in this company, that were build using contemporary BI and KDD techniques with respect to original methodology. In that sense, these case-studies verified theoretical methodology in real use.

L'étude structurale de l'interactome cellulaire peut conduire à des découvertes intéressantes sur les bases moléculaires de certaines pathologies. La modélisation par homologie et l'amarrage de protéines ("protein docking") sont deux approches informatiques pour modéliser la structure tri-dimensionnelle (3D) d'une interaction protéine-protéine (PPI). Des études précédentes ont montré que ces deux approches donnent de meilleurs résultats quand des données expérimentales sur les PPIs sont prises en compte. Cependant, les données PPI ne sont souvent pas disponibles sous une forme facilement accessible, et donc ne peuvent pas être re-utilisées par les algorithmes de prédiction. Cette thèse présente une approche systématique fondée sur l'extraction de connaissances pour représenter et manipuler les données PPI disponibles afin de faciliter l'analyse structurale de l'interactome et d'améliorer les algorithmes de prédiction par la prise en compte des données PPI. Les contributions majeures de cette thèse sont de : (1) décrire la conception et la mise en oeuvre d'une base de données intégrée KBDOCK qui regroupe toutes les interactions structurales domaine-domaine (DDI); (2) présenter une nouvelle méthode de classification des DDIs par rapport à leur site de liaison dans l'espace 3D et introduit la notion de site de liaison de famille de domaines protéiques ("domain family binding sites" ou DFBS); (3) proposer une classification structurale (inspirée du système CATH) des DFBSs et présenter une étude étendue sur les régularités d'appariement entre DFBSs en terme de structure secondaire; (4) introduire une approche systématique basée sur le raisonnement à partir de cas pour modéliser les structures 3D des complexes protéiques à partir des DDIs connus. Une interface web (http://kbdock.loria.fr) a été développée pour rendre accessible le système KBDOCK / Understanding how the protein interactome works at a structural level could provide useful insights into the mechanisms of diseases. Comparative homology modelling and ab initio protein docking are two computational methods for modelling the three-dimensional (3D) structures of protein-protein interactions (PPIs). Previous studies have shown that both methods give significantly better predictions when they incorporate experimental PPI information. However, in general, PPI information is often not available in an easily accessible way, and cannot be re-used by 3D PPI modelling algorithms. Hence, there is currently a need to develop a reliable framework to facilitate the reuse of PPI data. This thesis presents a systematic knowledge-based approach for representing, describing and manipulating 3D interactions to study PPIs on a large scale and to facilitate knowledge-based modelling of protein-protein complexes. The main contributions of this thesis are: (1) it describes an integrated database of non-redundant 3D hetero domain interactions; (2) it presents a novel method of describing and clustering DDIs according to the spatial orientations of the binding partners, thus introducing the notion of "domain family-level binding sites" (DFBS); (3) it proposes a structural classification of DFBSs similar to the CATH classification of protein folds, and it presents a study of secondary structure propensities of DFBSs and interaction preferences; (4) it introduces a systematic case-base reasoning approach to model on a large scale the 3D structures of protein complexes from existing structural DDIs. All these contributions have been made publicly available through a web server (http://kbdock.loria.fr)

The thesis is focused on data mining and its use in management of an enterprise. The thesis is structured into theoretical and practical part. Aim of the theoretical part was to find out: 1/ the most used methods of the data mining, 2/ typical application areas, 3/ typical problems solved in the application areas. Aim of the practical part was: 1/ to demonstrate use of the data mining in small Czech e-shop for understanding of the structure of the sale data, 2/ to demonstrate, how the data mining analysis can help to increase marketing results. In my analyses of the literature data I found decision trees, linear and logistic regression, neural network, segmentation methods and association rules are the most used methods of the data mining analysis. CRM and marketing, financial institutions, insurance and telecommunication companies, retail trade and production are the application areas using the data mining the most. The specific tasks of the data mining focus on relationships between marketing sales and customers to make better business. In the analysis of the e-shop data I revealed the types of goods which are buying together. Based on this fact I proposed that the strategy supporting this type of shopping is crucial for the business success. As a conclusion I proved the data mining is methods appropriate also for the small e-shop and have capacity to improve its marketing strategy.