Tyrimo tikslas – aprašyti bendruosius virusinių hepatitų, ŽIV ir kitų lytiškai plintančių infekcijų dėsningumus ir įvertinti HAV, HBV, HCV infekcijos paplitimą neatlygintinų kraujo donorų, duodančių pirmą kartą kraują, populiacijoje. Metodika. Tyrimui vykdyti gautas Vilniaus regioninio biomedicininių tyrimų etikos komiteto leidimas. Atlikta pirmą kartą neatlygintinai duodančių kraujo donorų anoniminė anketinė apklausa VŠĮ Nacionaliniame kraujo centre. Imunofermentiniu metodu buvo nustatomi: anti-HAV ir anti-HCV, anti-HBcor, anti-HBs, HBsAg. Nukleino rūgščių amplifikacijos testas taikytas HBV DNR ir HCV RNR nustatymui. Įvertinant ŽIV ir kitų lytiškai plintančių infekcijų ir virusinių hepatitų tendencijas buvo taikytas Mantel‘io testas ir paprastoji tiesinė regresija. Virusinių hepatitų serologinių žymenų paplitimas išreiškiamas procentais, įverčio tikslumui įvertinti apskaičiuotas pasikliautinis intervalas (PI) 95%, kategorinių duomenų analizei panaudotas χ² testas ir Fišerio tikslusis testas. Rizikos veiksnių įtaką vertinta taikant binarinę logistinę regresiją. Duomenų suderinamumui vertinti pasirinktas Hosmer‘io-Lemeshow‘o χ2 suderinamumo kriterijus. Vertinant, kaip modelio teoriniai dydžiai atitinka realiuosius, naudotas Cox’o ir Snell’o kriterijus, klasifikacinė analizuojamų požymių lentelė. Veiksnių įtaka įvertinta panaudojant šansų santykį su 95 % PI. Skirtumas statistiškai reikšmingas, kai p ≤ 0,05. Rezultatai. Tyrime dalyvavo 200 kraujo donorų. Analizei... [toliau žr. visą tekstą] / Aim: to describe epidemiology of the viral hepatitis A, B, C, HIV and other sexually transmitted infections (STD) and to estimate prevalence of HAV, HBV, HCV infections among first time non-remunerated blood donors population. Methodology: The study received approval from Vilnius Regional Biomedical Research Ethics Committee. First time non-remunerated blood donors participated in anonymous questionnaire survey in NGO National Blood Center. For anti-HAV, anti-HCV, anti-HBs, anti-Hbcor and HBsAg detection was used immunoenzyme method and for HBV DNR ir HCV RNR - nucleic acid amplification test. The Mantel trend test and linear regression method was used to evaluate the trend of viral hepatitis, HIV and other sexually transmitted infections. The prevalence of viral hepatitis serological markers was expressed in percentage points, the precision was evaluated at the confidence intervals (CI) of 95%, the comparison of categorical data was made using χ2 test and Fisher‘s exact test. For data analysis the following tests were used: for the risk factors – binary logistic regression; goodness of fit – Hosmer-Lemeshow χ2 test; Cox and Snell R Square, Classification Table. The statistical significance level p ≤ 0.05. Results: A total of 200 respondents haven been interviewed. Only 188 first time non-remunerated blood donors were selected for further analysis. Respondents minimum of age was 18 and maximum - 52 (Mean=22,6; Med=20,0), 47,9 % (n=90) of them were males, 52,1... [to full text]

SUMMARY Importance of blood safety by voluntary and altruistic blood donation is presented in the Master degree thesis. The major theoretical and practical solution of blood donations adopted during the analysis of Lithuanian and foreign legislation, results of analysis of society blood donor’s motivation and blood donors focusing problems. Master degree thesis consists of four main parts: analysis of the problem, background literature review, practical research and final conclusions. The first part of the thesis emphasizes the necessity for EU member states to ensure the provision for safe blood products which quality must fulfil the same EU standards, to restore public confidence. The main problem is transition from paid and relative’s blood donations to unpaid (voluntary) donations, which is revealed in the first part of thesis. The legislation regulating blood donations, the types of current donors and factors influencing on donors motivation are discussed in the second part. The second part consists of three chapters. The review of Lithuanian legislation about donor ship in Lithuania is considered in the first chapter. It is possible to state that till the year 2004 in Lithuania legal paid blood donations system was established which today barrier in transition is from paid and relatives blood donation to unpaid (voluntary) process. The second chapter describes the changing during last 3 year among Lithuanian blood donors and in donations. on process. And the last... [to full text]