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The purpose of this investigation was to study the syntheses of enol lactones and to prepare a series of amide derivatives of these compounds.

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Thesis (Ph. D.)--West Virginia University, 2006. / Title from document title page. Document formatted into pages; contains viii, 161, [213] p. : ill. Includes abstract. Includes bibliographical references (p. 154-161).

Sesquiterpene lactones contain £\,£]-unsaturated-£^-lactone as a major structural feature, which in recent studies have been shown to be associ- ated with anti-tumor, cytotoxic, anti-microbial and phytotoxic activities. Previous researchers isolated sesquiterpene lactones from Eupatorium formosanum Hay. Thus, we studied Eupatorium hualienense, a unique speces in Taiwan that grows near the eastern coast. Five new sesquiter- pene lactones of the germacranolide type, eupahualins A-E (1-5) along with the known lactone, eupasimplicin B (6). Their structures were determined by 1D-NMR(1H-NMR,13C-NMR) and 2D-NMR(COSY¡BNOESY¡BHMQC¡BHMBC). Eupahualin A (1) exhibits an aldehyde at C-10 and an a,b-unsatura ted acyl group at C-8. Eupahualin B (2) also has an aldehyde at C-10. The Z-form of C-4, C-5 double bond in eupahualin B (2) is the main difference from the trans-form C-4, C-5 double bond in eupahualin A (1). The difference of eupahualin C (3) and eupahualin A (1) lies in structure of a ester group at C-8. The methyl at C-4' in eupahualin A (1) was changed into hydroxy methyl while the hydroxy methyl of eupahualin A (1) was changed to methyl in eupahualin C (3). Eupahualin D (4) shows exocyclic double bond at C-10, OH at C-1 and OAc at C-3. An carboxylic group (COOH) at C-10 in eupahualin E (5) is the only difference from which in eupahualin A (1).

Thesis (M. Sc.)--University of Hong Kong, 1957. / References: p.48-51. "The occurrence of triterpenes in the aquifoliaceae and ericacear of Hong Kong, by H.R. Arthur, C.M. Lee and C.N. Ma" in pocket on inside of back cover. Type-written copy.

The polymerization of epsilon-caprolactone using tin(IV) carboxylates has been investigated and related to literature research. Polymers with broad MWD were obtained in quantitative yield. At 100% conversion polymer molecular weights ranged from 50,000 to almost 60,000. After an initial induction period, the polymerization shows zero order kinetics with respect to monomer and near first order kinetics with respect to catalyst. The mechanism of the polymerization is coordination-type, and is dependent on the presence of water or an alcoholic initiator. Added water decreases polymer molecular weight to approx. 30,000 at 100% conversion. The polymer has a terminal hydroxyl group and a terminal carboxyl group. The hydroxyl end is the reactive end in propagation. The carboxyl end and free carboxylic acid produced by the hydrolysis of the catalyst are responsible for the induction period.