Récemment, il a été proposé que le cervelet participe à l'acquisition de fonctions cognitives telle que la navigation. Un des mécanismes de plasticité synaptique du cervelet, la Dépression synaptique à Long Terme hétérosynaptique des fibres parallèles (DLT), est déjà connu pour être impliqué dans les apprentissages moteurs. L'objectif de ce travail de thèse était de déterminer si cette DLT participe également à l'acquisition d'une tâche de navigation. A l'aide de tests de navigation développés dans l'équipe, j'ai étudié les performances de souris transgéniques L7-PKCI dont ce mécanisme de DLT est altéré. Dans ces tests, les souris L7-PKCI étaient déficientes dans la capacité à élaborer une trajectoire efficace pour rejoindre leur but. Ces résultats suggèrent qu'un rôle essentiel du cervelet dans la navigation, et plus particulièrement de la DLT, est d'adapter en permanence la sortie motrice afin d'effectuer une trajectoire optimale.

<p>This mini-thesis aims to contribute to the debate around the legislative process by summarizing and analysing it comprehensively. It will, without being exhaustive, seek to identify the most important legal requirements that the future Statute needs to meet in order to facilitate cross-border business of small and medium-sized businesses. It seeks to systematise and comment on the most important legal Key Issues and therefore clarify and enrich the debate.</p>

Thesis (MPhil (Industrial Psychology))--University of Stellenbosch, 2006. / The impact of HIV/AIDS on small and medium enterprises (SMEs) is little known in South Africa. SMEs are arguably the largest employer, nationally, particularly in the Western Cape. Unfortunately, SMEs fall within the profile of businesses that have neither measured the prevalence and impact of HIV/AIDS on their businesses, nor devised a response to it. Realizing the risks and costs posed by HIV/AIDS in their business partners, chief executive officers of Western Cape corporate employers, signed a pledge to mentor SMEs. This paper focuses specifically on the mentorship programme of South African Breweries (SAB), which uses taverns and shebeens as a platform for education and awareness programmes in the fight against HIV/AIDS. This was a comparison study, which measured the Knowledge, Attitude and Practice (KAP) of trained and untrained tavern owners in four geographical areas to determine how business has responded to the epidemic. A quantitative research approach was used. The study revealed that the experimental group (trained tavern owners) displayed greater basic knowledge and understanding of HIV and AIDS, than the control group (untrained tavern owners). Some of the challenges facing workplace programmes were the involvement in programmes without enough information. The study concluded that without capacity building through methods such as instruction, coaching, providing experience, modeling, advising, training, information sharing and resources by corporates, the negative impact of HIV/AIDS in SMEs will not be mitigated. While the survey results suggest the need for greater involvement by corporates in mentoring programmes, further research on the role of the private sector in HIV/AIDS management is necessary.

Thesis (M.B.A.)-Business Studies Unit, Durban University of Technology, 2006 xii, 117 leaves / In 2005, Masonite (Africa) Ltd embarked on a level 1 learnership program, in line with the National Skills Development Strategy. Within a few months, it became apparent that there was a need to investigate the job satisfaction of the level 1 learners (learners) in the work component of their learnership program. To investigate their job satisfaction, a study was conducted which was guided by three objectives. These were: firstly to determine the general job satisfaction of the learners; secondly, to assess the satisfaction of the learners according to twenty dimensions of the job, as measured by the Minnesota Satisfaction Questionnaire (MSQ) and thirdly, to investigate the relationship between the job satisfaction of the learners and their demographic variables gender, age, work experience and level of education.

Cette thèse vise à mieux comprendre le rôle du facteur de transcription Nur77 au sein des fonctions physiologiques et pathologiques des voies de neurotransmission dopaminergiques des gaglions de la base. Nous basant sur une implication motrice de Nur77 au sein des dyskinésies induites à la L-DOPA (LIDs), nous avons voulu tester in vivo son implication éventuelle dans les phénomènes moteurs et de sensibilisation associés à l’amphétamine ainsi qu’une implication possible du récepteur nucléaire aux rétinoïdes RXR dont nous avons déjà démontré une implication dans les effets moteurs des antipsychotiques. Un deuxième volet de la recherche à consisté en l’étude de l’implication des extracellular signal-regulated kinase (ERK) et de la protéine kinase C (PKC) dans l’induction de l’ARNm des membres de la famille des Nurs suite à l’activation des cascades de signalisation des récepteurs dopamiergiques D1 et D2 in vivo pour une meilleure compréhension des mécanismes physiopatholoiques liés aux désordres dopaminergiques. Pour ce faire, nous avons, premièrement, soumis des souris sauvages et Nur77-/- à un paradigme de sensibilisation à l’amphétamine ainsi qu’a différents agonistes antagonistes RAR/RXR afin de tester l’implication de Nur77 et d’un éventuel complexe Nur77/RXR dans les effets de l’amphétamine. Deuxièmement, soumis des souris sauvages à une combinaison d’agonistes D1/D2 ou une injection d’antagoniste D2 avec ou sans inhibiteur (ERK1/2 ou PKC) afin de tester l’implication de ces kinases sur l’induction de l’ARNm des membres de la famille des Nurs par hybridation in situ. Nous avons ainsi pu démontrer 1- un rôle moteur de Nur77 dans les effets liés à l’amphétamine notamment avec une absence de stéréotypies et un allongement de la durée de la phase de locomotion chez les souris Nur77-/-; ainsi qu’un rôle éventuel du complexe potentiel Nur77/RXR dans les D1 à mieux définir. 2- un rôle des kinases ERKs et PKCs dans les cascades de signalisation des récepteurs dopaminergiques D1 et D2 menant à l’induction des ARNms de Nur77, Nor-1 et Nurr-1. En perspective, ces résultats nous ouvrent la voie vers une implication éventuelle de Nur77 dans les mécanismes d’apprentissage que sont le Long Terme Potentiation (LTP) et la Long Terme Depotentialisation (LTD) liés aux LIDs et à l’amphétamine. / This thesis aims to better understand the role of the transcription factor Nur77 in the physiological and pathological functions of dopaminergic neurotransmission pathways of the basal gaglia. Based on a motor involvement of Nur77 in L-DOPA induced dyskinesias (LIDs), we wanted to test its possible involvement in the motor mechanisms associated with amphetamine, a drug of abuse that targets the direct neuronal population of the basal ganglia such as L-DOPA. Involvement of extracellular signal-regulated kinase (ERK) and protein kinase C (PKC) has been widely demonstrated in the LIDs and the effects of amphetamine, we wanted to know whether Nur77 mRNA was controlled by these kinases in both the striatonigral and striataux palidal neurons in response to specific activation of the D1 and D2 receptors in vivo. Finally, a possible involvement of RXR has been demonstrated in the motor effects of antipsychotic drugs, so we wanted to test its potential involvement in the effects of amphetamine. To do this, we subjected wild-type mice and Nur77-/- mice to a paradigm of sensitization to amphetamine with or without RXR agonist (DHA) and antagonsite (HX531) to test: 1 - the involvement of Nur77 in the motor effects and the phenomenon of sensitization to amphetamine and 2 - the involvement of any complex Nur77/RXR in these effects. Second, wild-type mice were subjected to a combination of D1/D2 agonists or antagonists D2 with or without ERK inhibitor or PKC inhibitor to test in vivo the induction of the mRNA of the Nurs members family by in situ hybridization. We were able to demonstrate a role of Nur77 in the motor effects associated with amphetamine namely in the absence of stereotypy and a lengthening of the duration of the phase of locomotion in Nur77-/ - mice; and a possible role of the potential complex Nur77/RXR in D1 neurones needed to be better defined. In addition, it is clearly demonstrated that the induction of Nurs members mRNA responds to the activation of signaling cascades of dopaminergic D1 or D2 receptors within the involvement of PKC and ERK kinases is undubtable which opens us the way to a possible involvement of Nur77 in learning mechanisms associated with LIDs and amphetamine that are the Long Terme Potentiation (LTP) and the Long Terme Depotentialisation (LTD).

Thesis (M.A.)--Hong Kong Baptist University, 2005. / Dissertation submitted to the School of Communication. Includes bibliographical references (leaves 49-53).

Thesis (M.B.A.)--University of Hong Kong, 1996. / Includes bibliographical references (leaf 43-46).

Thesis (M.B.A.)--University of Hong Kong, 1995. / "1995"--Cover. Includes bibliographical references.

Thesis (MPhil (Information Science))--University of Stellenbosch, 2006. / Research Problem: Research commences at the point where within our department we begin to reflect on penetrating a new market. At first this reflection can be a very unstructured thought, a conjecture, a question, or hypothesis. In our case, it was about entering the Brazilian telematics or more commonly known the ‘tracking’ market. One of the most competitive markets in the world in terms of lower margins and a high number of competitors. Thus, the need to conduct research and CI analysis was paramount; this was because we had no idea about the Brazilian Telematics market. Therefore, we used research primarily to identify key issues relating to telematics (segment, competitors, customers etc) in Brazil. Like most companies however, our resources was limited in terms of investment and manpower. Apart from commissioning a very specific research, a great deal of desk, or secondary research was undertaken, this proved very valuable when formulating our strategy and achieving actionable results. Overall Objectives: The aim was to utilise mostly Competitive Intelligence and Market Research, two key components within Knowledge Management, to obtain and analyse competitive information from multiple sources to aid DigiCore’s international expansion. For the International team Competitive Intelligence was more than analyzing competitors - it was about making DigiCore more competitive relative to its existing set of competitors and potential competitors in international markets. Predictive analysis - analysing and documenting the likely moves of foreign markets and competitors was a key objective, especially in aiding our final strategy in Brazil. Various aspects of CI and Knowledge Management became indispensable to formulate and implement our strategy in Brazil. Research Design/Methodology: sampling, representativeness and data collection, CI, analysis and interpretation were key activities we conducted. In essence, for DigiCore a well-defined research problem is a precondition for our Brazilian project. The development of a research design thus follows logically from the research problem. A set of guidelines and instructions needed to be followed in order to address our research problem. Main Results: there is the misconception that CI and market research duplicate activities, whilst there may be some truth, for DigiCore CI was undertaken to understand our environment better – beyond percentages, graphs and statistic analysis. CI helped us to forecast, validate industry rumours and ultimately make effective decisions and thus being able to act rather than react. In fact, beginning any competitive intelligence project is a daunting task, but the end results made the whole process worth it. A further component was Managing Information Systems - Our technology is based on ‘complicated’ internal and external environments that need to be considered. So whilst, market research and competitive analysis may aid in the final decision making and ongoing strategies, without juxtaposing these efforts within an information systems environment, the whole project would be futile. Conclusion: there is no doubt in our minds, that by using CI, Market Research, and Knowledge Management in all of our key stages and activities we came closer to our overall objective of penetrating the Brazilian telematics market. Whilst it is too soon to evaluate our success and overall long-term growth, without the above tools we know for certain that there would not have been any success at all.

The thesis deals with meaning analysis of a market environment as a part of preparation to establish a new company. An academic part goes into enterprise, business plan and its stucture, characterization of limited company and also analyses external and internal environment. Practical part of thesis goes into actual analysis of a market environment, which refers to established company. The business plan for EM WORKS Ltd is also created. This company provides electro installation services. The final part of thesis includes strengths, weaknesses, opportunities and threats of established company gained through SWOT analysis.