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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
291

Jämförelse mellan total lungkapacitetberäknat utifrån single-breath metangasspädningrespektive kroppspletysmografi / Comparison between total lung capacity calculated bysingle-breath methane dilutionand by whole-body plethysmography

Jansson, Therése, Källmyr, Nicole January 2017 (has links)
Total lungkapacitet (TLC) är den totala volymen gas i lungorna efter en maximal inspiration. Den kan beräknas med kroppspletysmograf utifrån tryckförändringar och Boyles lag respektive utifrån gasspädning med metan alternativt helium som spädningsgas. Vanligen används kroppspletysmografi och för att kunna använda metangasspädning som substitut är överensstämmelsen mellan metoderna av intresse. Studiens syfte var att jämföra TLC från single-breath metangasspädning med TLC från kroppspletysmografi. Data gällande patienter som genomgått båda undersökningarna vid samma tillfälle enligt standardförfarande samlades in. Studien var en retrospektiv tvärsnittsstudie och populationen á 48 patienter innehöll lika många män som kvinnor, åldrar från 10 till 87 år samt med och utan angivna respiratoriska sjukdomar. TLC från kroppspletysmografin sträckte sig från 2,6 till 8,4 liter och TLC från metangasspädningen sträckte sig från 2,5 till 7,7 liter. TLC från gasspädningen var i genomsnitt 0,59 liter mindre än TLC från kroppspletysmografin. Metangasspädningen underskattade TLC med 11,3%. Skillnaden mellan kroppspletysmografins TLC och metangasspädningens TLC var signifikant vilket fastställdes med t-test för parvisa observationer. På grund av studiepopulationens natur finns behov av ytterligare studier med större populationer. TLC från metangasspädningen uppgick till 88,7% av TLC från kroppspletysmografin och gasspädning kan inte utan ökad risk för underskattning av TLC användas som substitut för kroppspletysmografi. / Total lung capacity (TLC) is the gas volume in the lungs after maximal inspiration. It can be calculated using whole-body plethysmography, pressure changes and Boyle’s law, or using gas dilution with methane or helium as inert gas. Agreement between the methods is of interest to make substitution of the more commonly used whole-body plethysmography with methane dilution possible. This retrospective cross-sectional study aimed to compare TLC from single-breath methane dilution with TLC from whole-body plethysmography. Data concerning patients who underwent these two standard procedure examinations in one visit was collected. The population of 48 had an even gender distribution, included ages 10 to 87 and patients with or without known respiratory diseases. TLC from whole-body plethysmography ranged between 2,6 and 8,4 liters. TLC from methane dilution ranged between 2,5 and 7,7 liters. TLC from gas dilution averaged 0,59 liters less than TLC from whole-body plethysmography and underestimated TLC by 11,3%. Paired samples t-test determined the difference between methods to be significant. Due to the nature of this population, further studies of larger populations are needed. Methane dilution TLC amounted to 88,7% of TLC from whole-body plethysmography which therefore cannot be substituted with methane dilution without increased risk of underestimating TLC.
292

Developing and Evaluating an Open Source Network Laboratory and Curriculum

Yuan, Dongqing 01 January 2011 (has links)
This study focused on developing and evaluating an open source software (OSS) network laboratory and curriculum for information technology (IT) program students. A review of literature revealed that to date there have been very few published studies on the development of the labs with clear and specific learning outcomes mapping the Institute for Electrical and Electronic Engineers (IEEE) and Association of Computing Machinery (ACM) IT computing curriculum recommendations. In addition, very few efforts have been taken to develop the lab and curriculum by using instructional design and learning theory from a pedagogical perspective. The goals of the research were to (a) analyze current computer networking education in the higher education system and the IEEE/ACM IT computing curriculum recommendation, (b) map the labs to the learning outcomes recommended by IEEE/ACM IT computing curriculum, (c) create and implement the OSS-based network laboratory and curriculum, and (d) evaluate the effectiveness of the laboratory and curriculum. The dissertation followed a developmental research model for the development of the lab and curriculum. The needs of the new curriculum were identified and the instructional goal was established. The 2008 ACM/IEEE computing curriculum recommendations were analyzed and translated into the lab objectives. Then five OSS labs were designed and implemented to cover the recommended learning outcomes. The curriculum was delivered to the students for two semester offerings at University of Wisconsin-Stout. An evaluation strategy which included a pretest, a posttest, and survey instrument was developed to measure students' performance and attitudes about the labs. The test questions were mapped to the learning objectives of the labs. The performances of the students from the intervention and control group were compared with paired t tests. Statistical analysis indicated that the labs were effective in introducing students to the concepts of computer networking. Students' comments also indicated that they preferred hands-on labs coupled with the classroom lectures. These results confirmed findings reported from previous studies. Additionally, based on some students' recommendation, the OSS network labs for distance online students could be a future direction to pursue.
293

Verification of Reveos Terumo 2C (2 component) method for introduction at the department of Transfusion Medicine in Falun

Diriye, Iman January 2018 (has links)
No description available.
294

Kan olika deponeringsmönster användas för en mer exakt deponering av partiklar i de små luftvägarna? / Can different deposition patterns be used for a more accurate deposition of particles in the small airways?

Björk, Evelina January 2021 (has links)
No description available.
295

Protective Relaying Student Laboratory

Pretzer, Kenan W 01 May 2017 (has links)
Facing a rapidly-changing power industry, the electrical engineering department at Cal Poly San Luis Obispo proposed Advanced Power Systems Initiatives to better prepare its students for entering the power industry. These initiatives call for the creation of a new laboratory curriculum that uses microprocessor-based relays to reinforce the fundamental concepts of power system protection. This paper summarizes a laboratory system fit for this task and presents a set of proposed laboratory experiments to establish a new laboratory course at Cal Poly. The experiments expose students to the capabilities of industry-standard microprocessor-based relays through hands-on procedures that demonstrate common power system protection schemes. Relays studied in this project support transformer, transmission line, and induction motor protection.
296

Metabolisk Respons vid ansträngning hos Claudicatio Intermittens, före och efter behandling av Cilostazol / Metabolic Response to Exercise in Intermittent Claudication, Before and After Cilostazol treatment

Danho, Hanan January 2021 (has links)
Claudicatio Intermittens (CI) är en kärlsjukdom som yttrar sig i form av perifer smärta och som begränsar ens gångsträcka. Patienter med CI har ett Ankel Brachial Index (ABI) på eller under 0,5. Mikrodialys kan användas för att analysera metaboliter såsom glukos, glycerol, laktat och pyruvat i en muskel. Denna teknik används i denna studie för att se metabolismen i muskeln före och efter Cilostazol Behandling. Syftet är att se om Cilostazol kan förbättra gångsträckan hos  patienter med CI och se om det sker en metabolisk förändring efter 6-8 veckors Cilostazol behandling. Totalt deltog 9 patienter i studien. Undersökningen hade en vilo-, arbets- och en återhämtningsfas. Patienterna fick en mikrodialys kateter insatt i musculus gastrocnemius där metaboliterna insamlades in i mikrovialer för att sedan kunna analyseras. ABI mättes med ankelbrachialmätning. Syrgasmättnad mättes med hjälp av en INVOS mätare. Under arbetsfasen där patienterna fick genomgå ett gångmattetest så noterades Absolute Walking Distance (AWD, eller maximal gångsträcka) och Initial Claudication Distance (ICD, eller gångsträcka utan smärtor). Efter undersökningen fick patienterna gå på en Cilostazol behandling i 6-8 veckor sedan gjordes samma undersökning om igen. Metabolisk skedde i stort sett ingen signifikant skillnad efter Cilostazol behandling. ICD och ABI visade signifikant skillnad efter Cilostazol behandling. En större och mer utvecklad studie hade behövts för att frågeställningen ska besvarar med en större säkerhet men en slutsats kan dras att Cilostazol kan förbättra gångsträckan hos patienter med CI. / Intermittent claudication (CI) is a vascular disease that manifests itself in the form of peripheral pain and limits one's Walking distance. Patients with CI have an Ankle Brachial Index (ABI) of or below 0.5. Microdialysis can be used to analyze metabolites such as glucose, glycerol, lactate and pyruvate in a muscle. This technique is used in this study to see the metabolism in the muscle before and after Cilostazol Treatment. The aim is to see if Cilostazol can improve the walking distance in patients with CI and see if there is a metabolic change after 6-8 weeks of Cilostazol treatment. A total of 9 patients participated in the study. The study had a rest, work and recovery phase. Patients received a microdialysis catheter inserted into the gastrocnemius muscle where the metabolites were collected in to microvials for analysis. ABI was measured with ankle brachial measurement. Oxygen saturation was measured using an INVOS meter. During the work phase where the patients had to undergo a walking mat test, Absolute Walking Distance (AWD, or maximum walking distance) and Initial Claudication Distance (ICD, or walking distance without pain) were noted. After the examination, the patients were given a Cilostazol treatment for 6-8 weeks, then the same examination was performed again. Metabolically, there was virtually no significant difference after Cilostazol treatment. ICD and ABI showed significant difference after Cilostazol treatment. A larger and more developed study would have been needed for the question to be answered with greater certainty but it can be concluded that Cilostazol improves the walking distance in patients with CI.
297

Diagnostisk träffsäkerhet och undersökningstid för kombinerat hjärt- och lungultraljud vid akutvårdsförloppet hos patienter med akut dyspné. : En litteraturstudie / Diagnostic accuracy and time duration for combined heart and lung ultrasound in the course of emergency care of patients with acute dyspnea. : – An overview

singstrand, carolin, Larsson, Sandra January 2020 (has links)
No description available.
298

The effects of NOX2 and NOX4 inhibitors on panc-1 cell viability

Sielinou Kamgang, Karl-Hermann January 2020 (has links)
Pancreatic cancer is a leading cause of cancer related deaths worldwide and has a low survival rate 1 year after diagnosis. It is therfore important to identify new biomarkers and treatments to improve disease outcome. This experiment investigated the effects of different NOX2 and NOX4 inhibitors on Panc-1 cell lines. Following 48 hours treatment, Cell viability analysis, Caspase 3/7 as well as ROS levels where measured to see how these factors were affected by the treatments. As the PI3K/AKT/mTOR and MAPK/ERK pathways, as well as G6PD and VEGF have been shown to influence cancer metastasis and invasiveness, a gene expression analysis (VEGF, G6PD, AKT2, ERK2) was also conducted. Results obtained showed a general decrease in cell viability with increasing concentrations of inhibitors used. While a general increase in Caspase 3/7 activity was observed, M166-0.6μM treatment showed decreased Caspase 3/7 activity, suggesting that other non-apoptotic cell death pathways such as necrosis could have been at play. A general increase in ROS activity was also observed and unexpected. Gene expression showed an increase in G6PD activity which could mean, the cancer cells increased antioxidant system activity to achieve redox balance due to the increased ROS levels. Some results obtained where unexpected and make it difficult to conclude how the treatments decreased cell viability. The results also suggest that other currently unknown mechanisms were at play in influencing cell viability. Most importantly, the results show that completely inhibiting NOX2 and NOX4 lead to the most significant decrease in cell viability.
299

Activation of NLRP3 inflammasome leads to the differential secretion of interleukins 1*/18 possibly linked to pyroptosis in THP-1 cells

Damiani, Jana January 2020 (has links)
Organisms are constantly exposed to microorganisms, some of which can cause disease, and yet, sickness only rarely occurs. Upon infection, the immune system is mobilized to eliminate the threat and re-establish homeostasis. The innate immune system, or “first line of defense”, is responsible for detecting infection and subsequently initiating inflammation. An important mediator of this process is the NLRP3 inflammasome, a molecular hub that coordinates the propagation of the immune response. Specifically, through the secretion of interleukins 1 and 18. These structurally related proteins are known to be secreted via unconventional pathways, however, the specificity of this matter remains inconclusive. One form of secretion suggested was “pyroptosis”, a form of cell death intended to enhance inflammation. The aim of this project was to quantify the secretion of structurally related interleukins-1/18 and evaluate the possible correlation with cell death over time. Samples were collected, interleukin release was quantified using sandwich ELISA and cell viability of stimulated cells was measured using the PrestoBlue assay. During prolonged inflammasome activation, IL-1 and IL-18 showed differences in their patterns of secretion and regulation. IL-1 was eventually downregulated whilst IL-18 maintained a constant increase over time. Strikingly, cell viability remained unchanged over the course of the experiment, demonstrating that pyroptosis is dispensable to the secretion of interleukins 1 and 18. Ultimately, the study of the relationship shared between these processes not only explains how immunity is founded, but also, uncovers the truths behind pathogenesis, how to prevent it and potentially find a cure for certain diseases.
300

Studying the impact of Ketone Ester HVMN on PANC-1 in vitro

Kureia, Nadin January 2020 (has links)
Cancer is considered to be one of the top deadly diseases, characterized by uncontrolled dividing of cells and reprogrammed metabolism. Cancer cells usually use high amounts of glucose, so they can produce the required energy for survival and proliferation, this process is called aerobic glycolysis. Studies have shown the inability of cancer using ketone bodies as fuel to generate ATP, therefore using ketone supplements could be an advantage in the fight of cancer. The aim of this thesis is to investigate the effect of ketone ester HVMN treatment, and investigate possible mechanism of its efficacy. Several methods were implemented, cell viability assay, glycolysis assay, apoptosis assay, and gene expression of several genes. This study showed a decrease in cell viability - when treating PANC-1 with different concentrations of the HVMN ketone ester, a significant decrease was recorded in the treatment concentrations of 5 and 50 mM after 24- and 48-hours. The lactate production was generally high for all concentrations of HVMN ketone ester as well as an increased apoptosis for all concentrations but only significant for treatment concentration of 1mM. The results also showed a significant increase in the expression levels of TFAM and cytochrome c (mt-CO1) indicating a functional mitochondrion. Increase mitochondrial activity suggest that ketogenic treatment HVMN induces a metabolic shift in cancer cells leading to the inhibition of glycolysis pathway, decreasing cell viability and inducing apoptosis.

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