The paper examines the status of selected disadvantaged groups in the Czech labour market in 2005-2012. The main goal of this paper is to test the hypothesis that these disadvantaged groups respond to changes in Czech GDP more sensitive than the general unemployment rate. This thesis describes the development of general unemployment rate and selected disadvantaged groups in studied period. The main hypothesis is verified using regression analysis performed on the time series. Empirical investigation, realized in this work, confirm this hypothesis in a group of graduates and persons at age 15-24. For persons with disabilities and persons at age 50-74 failed to confirm the hypothesis.