The decision-making process in highway construction projects identifies and selects the optimal alternative based on the user requirements and evaluation criteria. The current practice of the decision-making process does not consider all construction impacts in an integrated decision-making process. This dissertation developed a multi-criteria evaluation framework to support the decision-making process in highway construction projects. In addition to the construction cost and mobility impacts, reliability, safety, and emission impacts are assessed at different evaluation levels and used as inputs to the decision-making process. Two levels of analysis, referred to as the planning level and operation level, are proposed in this research to provide input to a Multi-Criteria Decision-Making (MCDM) process that considers user prioritization of the assessed criteria. The planning level analysis provides faster and less detailed assessments of the inputs to the MCDM utilizing analytical tools, mainly in a spreadsheet format. The second level of analysis produces more detailed inputs to the MCDM and utilizes a combination of mesoscopic simulation-based dynamic traffic assignment tool, and microscopic simulation tool, combined with other utilities. The outputs generated from the two levels of analysis are used as inputs to a decision-making process based on present worth analysis and the Fuzzy TOPSIS (Technique for Order Preference by Similarity to Ideal Situation) MCDM method and the results are compared.