The objective of this thesis research is to model the multiple program objectives used by Defence Research and Development Canada (DRDC) for the annual management and allocation of their broad range of Science and Technology (S&T) projects in order to best achieve the strategic goals of the agency and the government. This M.Sc. thesis presents methodologies, techniques and applications in Linear Programming (LP) and Multi-Criteria Decision Making (MCDM) for decision support in program prioritization and project selection of the DRDC S&T projects. The results of this research produce a model that supports decision makers effectively in the assignment of limited human and financial resources to competing S&T projects based on the evaluation of projects that merit funding and the multiple criteria established by the organization. While there is a well-defined set of criteria for the annual program formulation process, the selection procedure is currently based on simple scoring processes and expert judgement; it lacks a well-defined and structured analysis. The application of an MCDM framework is proposed to take advantage of the well-structured problem and improve annual renewal and ongoing monitoring or project performance measures. The results of the analysis provide a traceable and rigorous MCDM framework to evaluate the performance of DRDC S&T projects for enhanced resource allocation.

The objective of this thesis research is to model the multiple program objectives used by Defence Research and Development Canada (DRDC) for the annual management and allocation of their broad range of Science and Technology (S&T) projects in order to best achieve the strategic goals of the agency and the government. This M.Sc. thesis presents methodologies, techniques and applications in Linear Programming (LP) and Multi-Criteria Decision Making (MCDM) for decision support in program prioritization and project selection of the DRDC S&T projects. The results of this research produce a model that supports decision makers effectively in the assignment of limited human and financial resources to competing S&T projects based on the evaluation of projects that merit funding and the multiple criteria established by the organization. While there is a well-defined set of criteria for the annual program formulation process, the selection procedure is currently based on simple scoring processes and expert judgement; it lacks a well-defined and structured analysis. The application of an MCDM framework is proposed to take advantage of the well-structured problem and improve annual renewal and ongoing monitoring or project performance measures. The results of the analysis provide a traceable and rigorous MCDM framework to evaluate the performance of DRDC S&T projects for enhanced resource allocation.

The objective of this thesis research is to model the multiple program objectives used by Defence Research and Development Canada (DRDC) for the annual management and allocation of their broad range of Science and Technology (S&T) projects in order to best achieve the strategic goals of the agency and the government. This M.Sc. thesis presents methodologies, techniques and applications in Linear Programming (LP) and Multi-Criteria Decision Making (MCDM) for decision support in program prioritization and project selection of the DRDC S&T projects. The results of this research produce a model that supports decision makers effectively in the assignment of limited human and financial resources to competing S&T projects based on the evaluation of projects that merit funding and the multiple criteria established by the organization. While there is a well-defined set of criteria for the annual program formulation process, the selection procedure is currently based on simple scoring processes and expert judgement; it lacks a well-defined and structured analysis. The application of an MCDM framework is proposed to take advantage of the well-structured problem and improve annual renewal and ongoing monitoring or project performance measures. The results of the analysis provide a traceable and rigorous MCDM framework to evaluate the performance of DRDC S&T projects for enhanced resource allocation.

Significant investments are being made in the construction sector in order to raise the quality of the buildings and make them more sustainable and energy-efficient. The key aspect of these investments should be the purposeful optimization of the possible renovation and construction measures. However, this important matter usually is being pushed aside in favor of construction price and/or quality. Nevertheless, there are plenty of criteria that play a major role in building sustainable development. The main purpose of this study is to present a tool that combines multi-criteria decision making (MCDM) methods and building certification systems in order to make weighted decisions in complicated construction tasks. For this, a decision making model was developed with a focus on sustainability, buildings’ life cycle, MCDM methods, and building certification. The first section of this thesis, the introduction, discusses the importance of the investigated area, and the main objectives, tasks, and structure of the thesis. A literature review is presented in Section 2 – Theory. The main works in the area of sustainability, LCA, building certification, and MCDM are collected to show their role and importance and how they interact in the construction industry. Section 3 presents and discusses the main ideas and instructions of the proposed decision making model. Section 4 (Methodology) introduces the main existing and proposed techniques that I have used to implement the study. Sections 5 and 6 are the case studies, which demonstrate how the proposed methods can be used in practice. Final conclusions and recommendations are presented in Section 7. / <p>QC 20170209</p> / Funded by L.E. Lundberg foundation

The availability of water can be considered as one of the key ingredients to the human life, yet this resource remains scarcely available to those living in the rural parts of Africa. When water does present itself, it is often impure and requires extensive treatment. Water treatment systems, particularly those capable of treating water in rural areas, are currently areas of research and entrepreneurship focus, making a number of potential solutions available, and other still coming in. Unfortunately, these systems are not always capable of performing in particular socio-cultural and economic contexts, or are often deployed in the wrong rural areas. Therefore these systems do not perform at their optimal level of design. Rural areas in Africa have different socio-cultural and economic context from each other, and this needs to be taken into account if one is going to select the right water treatment system for a particular area. Using industrial engineering tools, two water treatment system selection models; an Additive Analytic Hierarchy Process model and a Fuzzy Logic based model, are presented and then integrated. These models take into account the context of selected rural area by pitting available water purification systems against selected criteria to determine if it is the right fit for the rural area considered. Both models are then pitted against each other to determine which is more adept at selecting the appropriate water purification system. Three water treatment alternatives were considered after an analysis was conducted on the available solutions on the market. The water treatment systems under consideration were the Biosand Filter with Zeolites (BSFZ), the Silver Impregnated Porous Pot, and A Borehole system. Makwane, a rural village in Limpopo, South Africa was used as a case study to demonstrate the application of the selection models. The BSFZ was selected as the ideal water treatment system to be implemented in Makwane / Dissertation (MEng)--University of Pretoria, 2016. / Industrial and Systems Engineering / MEng / Unrestricted

According to the IPCC (2007) fourth assessment report, small islands and coastal communities have a set of characteristics that makes them very vulnerable to climate change impacts, mainly sea-level rise and storm surges. Coastal hazards including inundation, salinisation of the water supply, and erosion threaten vital infrastructure that support coastal communities. Although Canada has the longest coastline in the world, little work has been done on impacts of climate change and adaptation to these impacts in the Canadian coastal zones. This research is part of an International Community-University Research Alliance (ICURA) C-Change, project to develop a multicriteria decision evaluation and support for the systems analysis of adaptation options for coastal communities toward adapting to environmental changes. This study estimates the vulnerability of coastal communities with respect to their environmental, economic, social, and cultural dimensions. It also applies a group version of the Analytical Hierarchy Process for identifying decisions that various stakeholders make on suggested adaptation strategies. This study develops a methodological framework that is applicable to various coastal and small island contexts. The application of the proposed framework is further discussed in a case study conducted on the communities of Charlottetown, Prince Edward Island (PEI), and Little Anse on Isle Madame, Nova Scotia. Specifically, the state of the Little Anse breakwater is analyzed and new adaptation options are presented and evaluated. This research has illustrated and applied a process of decision evaluation and support that explicitly engages multiple participants and critieria in complex problems situations involving environmental change in coastal communities.

According to the IPCC (2007) fourth assessment report, small islands and coastal communities have a set of characteristics that makes them very vulnerable to climate change impacts, mainly sea-level rise and storm surges. Coastal hazards including inundation, salinisation of the water supply, and erosion threaten vital infrastructure that support coastal communities. Although Canada has the longest coastline in the world, little work has been done on impacts of climate change and adaptation to these impacts in the Canadian coastal zones. This research is part of an International Community-University Research Alliance (ICURA) C-Change, project to develop a multicriteria decision evaluation and support for the systems analysis of adaptation options for coastal communities toward adapting to environmental changes. This study estimates the vulnerability of coastal communities with respect to their environmental, economic, social, and cultural dimensions. It also applies a group version of the Analytical Hierarchy Process for identifying decisions that various stakeholders make on suggested adaptation strategies. This study develops a methodological framework that is applicable to various coastal and small island contexts. The application of the proposed framework is further discussed in a case study conducted on the communities of Charlottetown, Prince Edward Island (PEI), and Little Anse on Isle Madame, Nova Scotia. Specifically, the state of the Little Anse breakwater is analyzed and new adaptation options are presented and evaluated. This research has illustrated and applied a process of decision evaluation and support that explicitly engages multiple participants and critieria in complex problems situations involving environmental change in coastal communities.

Streptomyces clavuligerus is well-known for synthesizing several &beta / -lactam antibiotics like cephamycin C which is produced through aspartic acid pathway initiated by aspartokinase (Ask) enzyme encoded by ask. Four different strains were constructed in our laboratory to increase cephamycin C production by S. clavuligerus. TB3585 and BA39 contained extra copies of ask gene on a multicopy plasmid, control strains TBV and BAV contained vector only in wild type strain NRRL3585 and hom-minus background, AK39, respectively. In this study, the effects of carbon and nitrogen sources incorporated into chemically defined medium were investigated for optimum growth and cephamycin C production by AK39. A modified-chemically defined medium (mCDM) was obtained by increasing the asparagine concentration two-fold and replacing glycerol with sucrose. Subsequently, growth and cephamycin C production by recombinant S. clavuligerus strains (TB3585, AK39, BA39, BAV, TBV) in Tryptic Soy Broth (TSB) and mCDM were compared. The specific antibiotic production in mCDM by TB3585 was 3.3- and 3.2-fold higher than TBV at 72h and 96h, respectively. Aspartokinase activity of S. clavuligerus recombinants was measured to verify the ask overexpression. TB3585 showed the highest activity at 48h. Finally, intracellular amino acid pools of the strains were measured to relate the Ask activity and antibiotic production to the amino acid content within the cells. AK39 was shown to have the highest intracellular levels of lysine, leading to cephamycin C precursor synthesis / lysine plus threonine, exerting concerted feedback inhibition on Ask enzyme / methionine, which cannot be produced by AK39 like threonine due to hom disruption.

According to the IPCC (2007) fourth assessment report, small islands and coastal communities have a set of characteristics that makes them very vulnerable to climate change impacts, mainly sea-level rise and storm surges. Coastal hazards including inundation, salinisation of the water supply, and erosion threaten vital infrastructure that support coastal communities. Although Canada has the longest coastline in the world, little work has been done on impacts of climate change and adaptation to these impacts in the Canadian coastal zones. This research is part of an International Community-University Research Alliance (ICURA) C-Change, project to develop a multicriteria decision evaluation and support for the systems analysis of adaptation options for coastal communities toward adapting to environmental changes. This study estimates the vulnerability of coastal communities with respect to their environmental, economic, social, and cultural dimensions. It also applies a group version of the Analytical Hierarchy Process for identifying decisions that various stakeholders make on suggested adaptation strategies. This study develops a methodological framework that is applicable to various coastal and small island contexts. The application of the proposed framework is further discussed in a case study conducted on the communities of Charlottetown, Prince Edward Island (PEI), and Little Anse on Isle Madame, Nova Scotia. Specifically, the state of the Little Anse breakwater is analyzed and new adaptation options are presented and evaluated. This research has illustrated and applied a process of decision evaluation and support that explicitly engages multiple participants and critieria in complex problems situations involving environmental change in coastal communities.

According to the IPCC (2007) fourth assessment report, small islands and coastal communities have a set of characteristics that makes them very vulnerable to climate change impacts, mainly sea-level rise and storm surges. Coastal hazards including inundation, salinisation of the water supply, and erosion threaten vital infrastructure that support coastal communities. Although Canada has the longest coastline in the world, little work has been done on impacts of climate change and adaptation to these impacts in the Canadian coastal zones. This research is part of an International Community-University Research Alliance (ICURA) C-Change, project to develop a multicriteria decision evaluation and support for the systems analysis of adaptation options for coastal communities toward adapting to environmental changes. This study estimates the vulnerability of coastal communities with respect to their environmental, economic, social, and cultural dimensions. It also applies a group version of the Analytical Hierarchy Process for identifying decisions that various stakeholders make on suggested adaptation strategies. This study develops a methodological framework that is applicable to various coastal and small island contexts. The application of the proposed framework is further discussed in a case study conducted on the communities of Charlottetown, Prince Edward Island (PEI), and Little Anse on Isle Madame, Nova Scotia. Specifically, the state of the Little Anse breakwater is analyzed and new adaptation options are presented and evaluated. This research has illustrated and applied a process of decision evaluation and support that explicitly engages multiple participants and critieria in complex problems situations involving environmental change in coastal communities.