<p>Current frontiers in complex stochastic modeling of high-dimensional processes include major emphases on so-called functional data: problems in which the data are snapshots of curves and surfaces representing fundamentally important scientific quantities. This thesis explores new Bayesian methodologies for functional data analysis. </p><p>The first part of the thesis places emphasis on the role of factor models in functional data analysis. Data reduction becomes mandatory when dealing with such high-dimensional data, more so when data are available on a large number of individuals. In Chapter 2 we present a novel Bayesian framework which employs a latent factor construction to represent each variable by a low dimensional summary. Further, we explore the important issue of modeling and analyzing the relationship of functional data with other covariate and outcome variables simultaneously measured on the same subjects.</p><p>The second part of the thesis is concerned with the analysis of circadian data. The focus is on the identification of circadian genes that is, genes whose expression levels appear to be rhythmic through time with a period of approximately 24 hours. While addressing this goal, most of the current literature does not account for the potential dependence across genes. In Chapter 4, we propose a Bayesian approach which employs latent factors to accommodate dependence and verify patterns and relationships between genes, while representing the true gene expression trajectories in the Fourier domain allows for inference on period, phase, and amplitude of the signal.</p><p>The third part of the thesis is concerned with the statistical analysis of computer models (simulators). The heavy computational demand of these input-output maps calls for statistical techniques that quickly estimate the surface output at untried inputs given a few preliminary runs of the simulator at a set design points. In this regard, we propose a Bayesian methodology based on a non-stationary Gaussian process. Relying on a model-based assessment of uncertainty, we envision a sequential design technique which helps choosing input points where the simulator should be run to minimize the uncertainty in posterior surface estimation in an optimal way. The proposed non-stationary approach adapts well to output surfaces of unconstrained shape.</p> / Dissertation

This study was designed to empirically derive latent classes of mothers who were sexually abused during childhood and to assess the association between depression, alcohol/drug use, supportive intimate partner, and specific classes. One hundred six women between the ages of 20 and 44 years (M = 27) who reported having been sexually abused during childhood (CSA) and 158 non-CSA mothers between the ages of 20 and 43 years (M = 23) were interviewed and assessed along six parenting dimensions. Logistic regression models evaluated the association between psychoemotional variables and specific classes. The final model consisted of three classes--53.2%, 31.7%, and 15.2%. Alcohol/drug use was not statistically significantly associated with either class. Maternal depression and intimate partner support were differentially associated with the three parenting classes. Empirical support is provided for distinct classes of mothers sexually abused in childhood. The data-driven categorization of CSA mothers provides research and clinical directions for future parenting of survivors of childhood sexual abuse.