Zugl.: Paderborn, Univ., Diss., 2008

Component-based applications require runtime support to be able to guarantee non-functional properties. This report proposes an architecture for a real-time-capable, component-based runtime environment, which allows to separate non-functional and functional concerns in component-based software development. The architecture is presented with particular focus on three key issues: the conceptual architecture, an approach including implementation issues for splitting the runtime environment into a real-time-capable and a real-time-incapable part, and details of contract negotiation. The latter includes selecting component implementations for instantiantion based on their non-functional properties.

Component-based applications require runtime support to be able to guarantee non-functional properties. This report proposes an architecture for a real-time-capable, component-based runtime environment, which allows to separate non-functional and functional concerns in component-based software development. The architecture is presented with particular focus on three key issues: the conceptual architecture, an approach including implementation issues for splitting the runtime environment into a real-time-capable and a real-time-incapable part, and details of contract negotiation. The latter includes selecting component implementations for instantiantion based on their non-functional properties.

Materialized views are a well-known optimization strategy with the potential for massive improvements in query processing time, especially for aggregation queries over large tables. To realize this potential, the query optimizer has to know how and when to exploit materialized views. Reporting functions represent a novel technique to formulate sequence-oriented queries in SQL. They provide a column-wise ordering, partitioning, and windowing mechanism for aggregation functions and therefore extend the well-known way of grouping and applying simple aggregation functions. Up to now, current work has not considered the frequently used reporting functions in data warehouse environments. In this paper, we introduce materialized reporting function views and show how to rewrite queries with reporting functions as well as aggregation queries to this new kind of materialized views. We demonstrate the efficiency of our approach with a large number of experiments.

Storing and processing data at different locations using a heterogeneous set of formats and data managements systems is state-of-the-art in many organizations. However, data analyses can often provide better insight when data from several sources is integrated into a combined perspective. In this paper we present an overview of our data integration system DataCalc. DataCalc is an extensible integration platform that executes adhoc analytical queries on a set of heterogeneous data processors. Our novel platform uses an expressive function shipping interface that promotes local computation and reduces data movement between processors. In this paper, we provide a discussion of the overall architecture and the main components of DataCalc. Moreover, we discuss the cost of integrating additional processors and evaluate the overall performance of the platform.

Many organizations store and process data at different locations using a heterogeneous set of formats and data management systems. However, data analyses can often provide better insight when data from several sources is integrated into a combined perspective. DataCalc is an extensible data integration platform that executes ad-hoc analytical queries on a set of heterogeneous data processors. The platform uses an expressive function shipping interface that promotes local computation and reduces data movement between processors. In this paper, we provide a detailed discussion of the architecture and implementation of DataCalc. We introduce data processors for plain files, JDBC, the MongoDB document store, and a custom in memory system. Finally, we discuss the cost of integrating additional processors and evaluate the overall performance of the platform. Our main contribution is the specification and evaluation of the DataCalc code delegation interface.

Model Driven Development is used to improve software quality and efficiency by automatically transforming abstract and formal models into software implementations. This is particularly sensible if the model’s integrity can be proven formally and is preserved during the model’s transformation. A standard to specify software model integrity is the Object Constraint Language (OCL). Another topic of research is the dynamic development of software components, enabling software system composition at component run-time. As a consequence, the system’s verification must be realized during system run-time (and not during transformation or compile time). Many established verification techniques cannot be used for run-time verification. A method to enable model-based run-time verification will be developed during this work. How OCL constraints can be transformed into executable software artifacts and how they can be used in the component-based system Treaty will be the major task of this diploma thesis. / Modellgetriebene Entwicklung dient der Verbesserung von Qualität und Effizienz in der Software-Entwicklung durch Automatisierung der notwendigen Transformationen von abstrakten bzw. formalen Modellen bis zur Implementierung. Dies ist insbesondere dann sinnvoll, wenn die Integrität der ursprünglichen Modelle formal bewiesen werden kann und durch die Transformation gewährleistet wird. Ein Standard zur Spezifikation der Integrität von Softwaremodellen ist die Object Constraint Language (OCL). Eine weitere Forschungsrichtung im Software-Engineering ist die Entwicklung von dynamischen Komponenten-Modellen, die die Komposition von Softwaresystemen im laufenden Betrieb ermöglichen. Dies bedeutet, dass die Systemverifikation im laufenden Betrieb realisiert werden muss. Die meisten der etablierten Verifikationstechniken sind dazu nicht geeignet. In der Diplomarbeit soll ausgehend von diesem Stand der Technik eine Methode zur modellbasierten Verifikation zur Laufzeit entwickelt werden. Insbesondere soll untersucht werden, wie OCL-Constraints zur Laufzeit in ausführbare Software-Artefakte übersetzt und in dem komponentenbasierten System Treaty verwendet werden können.

Background To investigate vascular-related pathophysiological characteristics of two human lung cancers with modifiable vascularisation using MRI and CT. Methods Tumour xenografts with modifiable vascularisation were established in 71 rats (approval by the Animal Care Committee was obtained) by subcutaneous transplantation of two human non-small-cell lung cancer (NSCLC) cells (A549, H1299) either alone or co-transplanted with vascular growth promoters. The vascularity of the tumours was assessed noninvasively by MRI diffusion-weighted-imaging (DWI), T2-weighted, and time-of-flight (TOF) sequences) as well as contrast-enhanced CT (CE-CT), using clinical scanners. As a reference standard, histological examinations (CD-31, fluorescent beads) were done after explantation. Results Microvessel density (MVD) was higher in co-transplanted tumours (171 ± 19 number/mm2) than in non-co-transplanted tumours (111 ± 11 number/mm2; p = 0.002). Co-transplanted tumours showed higher growth rates and larger tumour vessels at TOF-MRI as well as larger necrotic areas at CE-CT. In co-transplanted tumours, DWI revealed higher cellularity (lower minimal ADCdiff 166 ± 15 versus 346 ± 27 mm2/s × 10−6; p < 0.001), highly necrotic areas (higher maximal ADCdiff 1695 ± 65 versus 1320 ± 59 mm2/s × 10−6; p < 0.001), and better-perfused tumour stroma (higher ADCperf 723 ± 36 versus 636 ± 51 mm2/s × 10−6; p = 0.005). Significant correlations were found using qualitative and quantitative parameters: maximal ADCperf and MVD (r = 0.326); maximal ADCdiff and relative necrotic volume on CE-CT (r = 0.551); minimal ADCdiff and MVD (r = −0.395). Conclusions Pathophysiological differences related to vascular supply in two human lung cancer cell lines with modifiable vascularity are quantifiable with clinical imaging techniques. Imaging parameters of vascularisation correlated with the results of histology. DWI was able to characterise both the extent of necrosis and the level of perfusion.

Background To investigate vascular-related pathophysiological characteristics of two human lung cancers with modifiable vascularisation using MRI and CT. Methods Tumour xenografts with modifiable vascularisation were established in 71 rats (approval by the Animal Care Committee was obtained) by subcutaneous transplantation of two human non-small-cell lung cancer (NSCLC) cells (A549, H1299) either alone or co-transplanted with vascular growth promoters. The vascularity of the tumours was assessed noninvasively by MRI diffusion-weighted-imaging (DWI), T2-weighted, and time-of-flight (TOF) sequences) as well as contrast-enhanced CT (CE-CT), using clinical scanners. As a reference standard, histological examinations (CD-31, fluorescent beads) were done after explantation. Results Microvessel density (MVD) was higher in co-transplanted tumours (171 ± 19 number/mm2) than in non-co-transplanted tumours (111 ± 11 number/mm2; p = 0.002). Co-transplanted tumours showed higher growth rates and larger tumour vessels at TOF-MRI as well as larger necrotic areas at CE-CT. In co-transplanted tumours, DWI revealed higher cellularity (lower minimal ADCdiff 166 ± 15 versus 346 ± 27 mm2/s × 10−6; p < 0.001), highly necrotic areas (higher maximal ADCdiff 1695 ± 65 versus 1320 ± 59 mm2/s × 10−6; p < 0.001), and better-perfused tumour stroma (higher ADCperf 723 ± 36 versus 636 ± 51 mm2/s × 10−6; p = 0.005). Significant correlations were found using qualitative and quantitative parameters: maximal ADCperf and MVD (r = 0.326); maximal ADCdiff and relative necrotic volume on CE-CT (r = 0.551); minimal ADCdiff and MVD (r = −0.395). Conclusions Pathophysiological differences related to vascular supply in two human lung cancer cell lines with modifiable vascularity are quantifiable with clinical imaging techniques. Imaging parameters of vascularisation correlated with the results of histology. DWI was able to characterise both the extent of necrosis and the level of perfusion.

Within business Intelligence contexts, the importance of data mining algorithms is continuously increasing, particularly from the perspective of applications and users that demand novel algorithms on the one hand and an efficient implementation exploiting novel system architectures on the other hand. Within this paper, we focus on the latter issue and report our experience with the exploitation of graphic card processor technology within the SAP NetWeaver business intelligence accelerator (BIA). The BIA represents a highly distributed analytical engine that supports OLAP and data mining processing primitives. The system organizes data entities in column-wise fashion and its operation is completely main-memory-based. Since case studies have shown that classic data mining queries spend a large portion of their runtime on scanning and filtering the data as a necessary prerequisite to the actual mining step, our main goal was to speed up this expensive scanning and filtering process. In a first step, the paper outlines the basic data mining processing techniques within SAP NetWeaver BIA and illustrates the implementation of scans and filters. In a second step, we give insight into the main features of a hybrid system architecture design exploiting graphic card processor technology. Finally, we sketch the implementation and give details of our vast evaluations.