Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (p. 120-127).

Thesis (Ph. D.)--Rutgers University, 2007. / "Graduate Program in Computer Science." Includes bibliographical references (p. 133-136).

Thesis (M.S.)--Oregon State University, 2009. / Printout. Includes bibliographical references (leaves 38-40). Also available on the World Wide Web.

Thesis (Ph.D)--Electrical and Computer Engineering, Georgia Institute of Technology, 2010. / Committee Chair: Hu, Xiaoping; Committee Co-Chair: Vachtsevanos, George; Committee Member: Butera, Robert; Committee Member: Gurbaxani, Brian; Committee Member: Mayberg, Helen; Committee Member: Yezzi, Anthony. Part of the SMARTech Electronic Thesis and Dissertation Collection.

Thesis (Ph. D.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains x, 97 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 81-83).

Multiscale modeling has become an important tool in material mechanics because material behavior can exhibit varied properties across different length scales. The use of multiscale modeling is essential for accurately capturing these characteristics and predicting material behavior. Mesh-free methods have also been gaining attention in recent years due to their innate ability to handle complex geometries and large deformations. These methods provide greater flexibility and efficiency in modeling complex material behavior, especially for problems involving discontinuities, such as fractures and cracks. Moreover, mesh-free methods can be easily extended to multiple lengths and time scales, making them particularly suitable for multiscale modeling. The thesis focuses on two specific problems of multiscale modeling with mesh-free methods. The first problem is the atomistically informed constitutive model for the study of high-pressure induced densification of silica glass. Molecular Dynamics (MD) simulations are carried out to study the atomistic level responses of fused silica under different pressure and strain-rate levels, Based on the data obtained from the MD simulations, a novel continuum-based multiplicative hyper-elasto-plasticity model that accounts for the anomalous densification behavior is developed and then parameterized using polynomial regression and deep learning techniques. To incorporate dynamic damage evolution, a plasticity-damage variable that controls the shrinkage of the yield surface is introduced and integrated into the elasto-plasticity model. The resulting coupled elasto-plasticity-damage model is reformulated to a non-ordinary state-based peridynamics (NOSB-PD) model for the computational efficiency of impact simulations. The developed peridynamics (PD) model reproduces coarse-scale quantities of interest found in MD simulations and can simulate at a component level. Finally, the proposed atomistically-informed multiplicative hyper-elasto-plasticity-damage model has been validated against limited available experimental results for the simulation of hyper-velocity impact simulation of projectiles on silica glass targets. The second problem addressed in the thesis involves the upscaling approach for multi-porosity media, analyzed using the so-called MultiSPH method, which is a sequential SPH (Smoothed Particle Hydrodynamics) solver across multiple scales. Multi-porosity media is commonly found in natural and industrial materials, and their behavior is not easily captured with traditional numerical methods. The upscaling approach presented in the thesis is demonstrated on a porous medium consisting of three scales, it involves using SPH methods to characterize the behavior of individual pores at the microscopic scale and then using a homogenization technique to upscale to the meso and macroscopic level. The accuracy of the MultiSPH approach is confirmed by comparing the results with analytical solutions for simple microstructures, as well as detailed single-scale SPH simulations and experimental data for more complex microstructures.

As self-awareness is important to human higher level cognition so too is the ability to self-model important to performing complex behaviors. The power of these self-models is one that I demonstrate grows with the complexity of problems being solved, and thus provides the framework for higher level cognition. I demonstrate that self-models can be used to effectively control and improve on existing control algorithms to allow agents to perform complex tasks. I further investigate new ways in which these self-models can be learned and applied to increase their efficacy and improve the ability of these models to generalize across tasks and bodies. Finally, I demonstrate the overall power of these self-models to allow for complex tasks to be completed with little data across a variety of bodies and using a number of algorithms.

Most medical treatments have been developed aiming at the best-on-average efficacy for large populations, resulting in treatments successful for some patients but not for others. It necessitates the need for precision medicine that tailors medical treatment to individual patients. Omics data holds comprehensive genetic information on individual variability at the molecular level and hence the potential to be translated into personalized therapy. However, the attempts to transform omics data-driven insights into clinically actionable models for individual patients have been limited. Meanwhile, advances in deep learning, one of the most promising branches of artificial intelligence, have produced unprecedented performance in various fields. Although several deep learning-based methods have been proposed to predict individual phenotypes, they have not established the state of the practice, due to instability of selected or learned features derived from extremely high dimensional data with low sample sizes, which often results in overfitted models with high variance. To overcome the limitation of omics data, recent advances in deep learning models, including representation learning models, generative models, and interpretable models, can be considered. The goal of the proposed work is to develop deep learning models that can overcome the limitation of omics data to enhance the prediction of personalized medical decisions. To achieve this, three key challenges should be addressed: 1) effectively reducing dimensions of omics data, 2) systematically augmenting omics data, and 3) improving the interpretability of omics data. / Doctor of Philosophy / Most medical treatments have been developed aiming at the best-on-average efficacy for large populations, resulting in treatments successful for some patients but not for others. It necessitates the need for precision medicine that tailors medical treatment to individual patients. Biological data such as DNA sequences and snapshots of genetic activities hold comprehensive information on individual variability and hence the potential to accelerate personalized therapy. However, the attempts to transform data-driven insights into clinical models for individual patients have been limited. Meanwhile, advances in deep learning, one of the most promising branches of artificial intelligence, have produced unprecedented performance in various fields. Although several deep learning-based methods have been proposed to predict individual treatment or outcome, they have not established the state of the practice, due to the complexity of biological data and limited availability, which often result in overfitted models that may work on training data but not on test data or unseen data. To overcome the limitation of biological data, recent advances in deep learning models, including representation learning models, generative models, and interpretable models, can be considered. The goal of the proposed work is to develop deep learning models that can overcome the limitation of omics data to enhance the prediction of personalized medical decisions. To achieve this, three key challenges should be addressed: 1) effectively reducing the complexity of biological data, 2) generating realistic biological data, and 3) improving the interpretability of biological data.

We are witnessing a proliferation of massive visual data. Visual content is arguably the fastest growing data on the web. Photo-sharing websites like Flickr and Facebook now host more than 6 and 90 billion photos, respectively. Unfortunately, scaling existing computer vision algorithms to large datasets leaves researchers repeatedly solving the same algorithmic and infrastructural problems. Designing and implementing efficient and provably correct computer vision algorithms is extremely challenging. Researchers must repeatedly solve the same low-level problems: building and maintaining a cluster of machines, formulating each component of the computer vision pipeline, designing new deep learning layers, writing custom hardware wrappers, etc. This thesis introduces CloudCV, an ambitious system that contain algorithms for end-to-end processing of visual content. The goal of the project is to democratize computer vision; one should not have to be a computer vision, big data and deep learning expert to have access to state-of-the-art distributed computer vision algorithms. We provide researchers, students and developers access to state-of-art distributed computer vision and deep learning algorithms as a cloud service through web interface and APIs. / Master of Science

Computed Tomography (CT) finds applications across domains like medical diagnosis, security screening, and scientific research. In medical imaging, CT allows physicians to diagnose injuries and disease more quickly and accurately than other imaging techniques. However, CT is one of the most significant contributors of radiation dose to the general population and the required radiation dose for scanning could lead to cancer. On the other hand, a shallow radiation dose could sacrifice image quality causing misdiagnosis. To reduce the radiation dose, sparse-view CT, which includes capturing a smaller number of projections, becomes a promising alternative. However, the image reconstructed from linearly interpolated views possesses severe artifacts. Recently, Deep Learning-based methods are increasingly being used to interpret the missing data by learning the nature of the image formation process. The current methods are promising but operate mostly in the image domain presumably due to lack of projection data. Another limitation is the use of simulated data with less sparsity (up to 75%). This research aims to interpolate the missing sparse-view CT in the sinogram domain using deep learning. To this end, a residual U-Net architecture has been trained with patch-wise projection data to minimize Euclidean distance between the ground truth and the interpolated sinogram. The model can generate highly sparse missing projection data. The results show improvement in SSIM and RMSE by 14% and 52% respectively with respect to the linear interpolation-based methods. Thus, experimental sparse-view CT data with 90% sparsity has been successfully interpolated while improving CT image quality. / Master of Science / Computed Tomography is a commonly used imaging technique due to the remarkable ability to visualize internal organs, bones, soft tissues, and blood vessels. It involves exposing the subject to X-ray radiation, which could lead to cancer. On the other hand, the radiation dose is critical for the image quality and subsequent diagnosis. Thus, image reconstruction using only a small number of projection data is an open research problem. Deep learning techniques have already revolutionized various Computer Vision applications. Here, we have used a method which fills missing highly sparse CT data. The results show that the deep learning-based method outperforms standard linear interpolation-based methods while improving the image quality.