This thesis represents a systematic study of electronic structure of the modulation-free Pb-doped Bi2212 superconducting cuprates with respect to interlayer coupling done by using the angle-resolved photoemission spectroscopy (ARPES), which is a leading technique in the experimental investigation of the single particle excitations in solids. The results presented in this work indicate a very different origin for the observed complex spectra lineshape. Specifically, the peak-dip-hump lineshape can be easily understood in terms of the superposition of spectral features due to bilayer band splitting, namely the splitting of the CuO2 plane derived electronic structure in bonding and antibonding bands due to the interlayer coupling of CuO2 bilayer blocks within the unit cell of Bi2212. By performing experiments at synchrotron beamlines where the energy of the incoming photons can be tuned over a very broad range, the detailed matrix elements energy dependence for both bonding and antibonding bands was determined. This gave the opportunity to study the electronic properties these two bands separately. For the first time, it was proved that the superconducting gap has the same value and symmetry for both bands. Furthermore, having recognized and sorted out the bilayer splitting effects, it became possible to identify more subtle effects hidden in the details of the ARPES lineshapes. On underdoped samples an "intrinsic" peak-dip-hump structure due to the interaction between electrons and a bosonic mode was observed. Studying the doping, temperature, and momentum dependence of the photoemission spectra it was established that: the mode has a characteristic energy of 38-40 meV and causes strong renormalization of the electronic structure only in the superconducting state; the electron-mode coupling is maximal around the (?à,0) point in momentum space and is strongly doping dependent (being greatly enhanced in the underdoped regime). From the above, it was concluded that the bosonic mode must correspond to the sharp magnetic resonance mode observed in inelastic neutron scattering experiments, and that this coupling is relevant to superconductivity and the pairing mechanism in the cuprates.