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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Secreção vaginal anormal: fatores de risco e associação entre diagnóstico clínico e citológico / Abnormal vaginal secretion: risck factors and association between clinical and cytological diagnosis

Camargo, Kelvia Cristina de 18 June 2014 (has links)
Submitted by Jaqueline Silva (jtas29@gmail.com) on 2016-09-12T18:15:05Z No. of bitstreams: 2 Dissertação - Kélvia Cristina de Camargo - 2014.pdf: 1810460 bytes, checksum: 3f5dbf06427d9e09b4ebb202a6433de2 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2016-09-12T18:15:17Z (GMT) No. of bitstreams: 2 Dissertação - Kélvia Cristina de Camargo - 2014.pdf: 1810460 bytes, checksum: 3f5dbf06427d9e09b4ebb202a6433de2 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2016-09-12T18:15:17Z (GMT). No. of bitstreams: 2 Dissertação - Kélvia Cristina de Camargo - 2014.pdf: 1810460 bytes, checksum: 3f5dbf06427d9e09b4ebb202a6433de2 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2014-06-18 / INTRODUCTION. The balance of the vaginal microbiota is related to a woman's hormonal status, microbial metabolism, sexual stimulation and immune response. The imbalance of vaginal flora, induces elevation of pH, favoring infections and abnormal vaginal secretion. OBJECTIVES. Estimating the prevalence of the bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) and trichomoniasis in cervical cytology smears, stained by the method of Papanicolaou; studying the association between sociodemographic and behavioral variables and microbiological findings; assessing the degree of agreement between the clinical characteristics of vaginal secretion and microbiological findings. METHODS. Crosssectional study performed in 302 women aged 20 to 87, referred to the Gynecology Outpatient Clinic of the Integrated Healthcare Center Chácara do Governador, in Goiânia, Goiás, from June 2012 to May 2013. All were patients interviewed and underwent a gynecology test. Cervical smear was also collected for cytology. The samples were analyzed at the Rômulo Rocha Clinical Analysis Center of the School of Pharmacy of the Federal University of Goiás - UFG. A multiple logistic regression analysis was performed to identify sociodemographic and behavioral factors associated to the microbiological findings from the cytology smear. The odds ratio (OR) and adjusted OR were calculated and the confidence interval was set at 95% (CI 95%). The kappa index was used to evaluate the degree of agreement between the characteristics of the vaginal secretion and microbiological findings. RESULTS. The prevalence of BV, VVC and trichomoniasis was 25.5%, 9.3% and 2.0%, respectively. The report of a previous STI (OR=2.27; CI 95%=1.15-4.49; p=0.018) and the use of vaginal douching were associated to the diagnosis of BV (OR=4.71; CI 95%: 2.65-8.38; p=<0.001). None of the variables studied presented a significant association with the microbiological findings of VVC and trichomoniasis. The degree of agreement between the clinical evaluation of vaginal secretion and the microbiological diagnosis of BV, candidiasis and trichomoniasis, as analyzed by the kappa index was 0.47, 0.23 and 0.28, respectively. CONCLUSION. The most prevalent microbiological diagnosis was BV. The association found between the use of vaginal douching and BV indicated that it may be a triggering factor. The clinical evaluation of vaginal secretion presented a moderate to weak degree of agreement with the microbiological diagnosis, indicating the need for complementary investigation. / INTRODUÇÃO. O equilíbrio da microbiota vaginal está relacionado ao estado hormonal, metabolismo microbiano, estimulação sexual e resposta imune da mulher. O desequilíbrio da flora vaginal, induz a elevação do pH, favorecendo infecções e secreção vaginal anormal. OBJETIVOS. Estimar a prevalência da vaginose bacteriana (VB), candidíase vulvovaginal (CVV) e tricomoníase em esfregaços citológicos do colo uterino, corados pelo método de Papanicolaou; avaliar a associação entre variáveis sociodemográficas e comportamentais e os achados microbiológicos; Avaliar o grau de concordância entre as características clínicas da secreção vaginal e os achados microbiológicos. MÉTODOS. Estudo de corte transversal em 302 mulheres de 20 a 87 anos referenciadas à consulta no Ambulatório de Ginecologia do Centro de Atendimento Integral à Saúde da Chácara do Governador, em Goiânia, Goiás. Todas foram submetidas à entrevista, exame ginecológico e coleta de esfregaço para estudo citológico, no período de junho de 2012 a maio de 2013. As amostras foram analisadas no Centro de Análises Clínicas Rômulo Rocha da Faculdade de Farmácia/UFG. Análise de regressão logística foi realizada para identificar fatores sociodemográficos e comportamentais associados aos achados microbiológicos no esfregaço citológico. Foi calculada a razão de odds (OR) e a OR ajustada com intervalo de confiança de 95% (IC95%). O grau de concordância entre as características da secreção vaginal e os achados microbiológicos foi avaliado pelo índice kappa. RESULTADOS. A prevalência da VB, CVV e tricomoníase foi de 25,5%, 9,3% e 2,0%, respectivamente. O relato IST prévia (OR=2,27; IC95%=1,15-4,49; p=0,018) e o uso de ducha vaginal associou-se ao diagnóstico de VB (OR=4,71; IC95%: 2,65- 8,38; p=<0,001). Nenhuma variável estudada apresentou associação significativa com os achados microbiológicos de CVV e tricomoníase. O grau de concordância entre a avaliação clínica da secreção vaginal e o diagnóstico microbiológico de VB, candidíase e tricomoníase, avaliados pelo índice kappa foi de 0,47, 0,23 e 0,28, respectivamente. CONCLUSÃO. O diagnóstico microbiológico de maior prevalência foi a VB. A associação entre o uso de ducha vaginal e VB aponta para seu possível fator desencadeante. A avaliação clínica da secreção vaginal apresentou grau de concordância moderado a fraco com o diagnóstico microbiológico, o que indica a necessidade de avaliação complementar.

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