Blood group glycolipids are important tools in the study of microbial receptor interactions and other biological phenomena. Presently blood group glycolipids of interest are isolated from biological samples. However, all glycolipids are not readily available due to the low frequency of some phenotypes in the general population. The ability to acquire the rare glycolipids from the degradation of common glycolipids would be a useful alternative to trying to obtain the molecules from biological sources.This research set out to establish the ability of blood group glycolipids to be degraded into useful glycolipids in a controlled manner by acid hydrolysis and possibly metal catalysis. The initial experiments investigated the degradation/hydrolysis of the more readily available glycolipid globoside with a range of salts and acids to establish degradation concepts such as; temperature, type of acid, acid concentration, and the role of metal ions in glycolipid degradation. These concepts then led to a series of degradation experiments with the blood group glycolipids Leb and ALeb. These glycolipids were incubated with a range of acid concentrations and varying temperatures. Thin layer chromatography separation and chemical and immunochemical staining were the main methods used to identify the products of degradation.It was established that metal ions were not directly involved in the catalysis of glycolipids in the short-term, however some metal ions were indirectly implicated in their degradation due to their ability to form acid solutions. Acid hydrolysis was established as the principle mechanism for glycan chain degradation. In general it was found that the glycan chain primarily lost its fucose groups (in no particular order) and was then followed by sequential degradation of the remaining glycan chain. The glycan chain also appeared to have a protective function on the ceramide moiety. Degradation of globoside established a simple sequential pathway of glycan chain reduction from the non-reducing end. Blood group glycolipids ALeb and Leb first lost their fucose side groups followed by sequential reduction of the glycan chain. Although not fully controllable, degradation of Leb was able to produce Lea, Led and Lec. In contrast degradation of ALeb did not produce any Lea or Led. Instead A-type 1 and two novel A-like structures, 'linear A' and 'GalNAc-Lea' were generated. Lec was only produced from ALeb in extremely acidic conditions. This research established the ability to generate, by acid hydrolysis, a range of rare and "unnatural" novel glycolipids from more commonly available structures. It is of interest that the so-called unnatural glycolipids obtained from the acid hydrolysis of ALeb may, in theory, occur naturally in the acid environment of the stomach, and as such could have the potential to be implicated in disease. It is probable that by applying the principles learned here, a range of novel and natural structures suitable for use in the study of biological interactions can be obtained.

Thesis (M.A.)--Trinity Evangelical Divinity School, 1995. / Abstract. Includes bibliographical references (leaves 90-93).

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The 'postmodern challenge' is increasingly felt in the 'end of modernity' to which Gianni Vattimo refers. The West and the world has hitherto been dominated by what Andrew Gamble characterises as the Modern or Western Ideology. But the validity of that worldview and its associated ways of thinking, going back to the 'Enlightenment' and beyond, has come to be radically questioned. It is within this context that the work and thought of CS Lewis is examined. Although Lewis is generally recognised, and regarded himself, as conservative and even reactionary, there is a paradoxical quality to his conservatism, the elements of which coexist with features which might be regarded as liberal and as radically socialist respectively. Similarly, his commitment to the religious and cultural tradition of Western Europe co-exists with a vehement anticolonialism. A paradoxical association of postmodermism with 'premodernity' has been widely noted in Buddhism and, by Derrida, in Eastern Christian theology. This thesis seeks to demonstrate that a paradoxical postmodernism is evident in the thought of Lewis. One source suggested for this is his interest in Eastern Christianity. Another is identified as the influence on Lewis of the opposition of Romanticism to 'Enlightenment' modernity. But Lewis's own engagement with modernity is also shown to be significant. Two broad trends in postmodernism are discussed. The affinities of Lewis's thought with the nihilistic tradition of postmodernism, going back to Nietzsche, is traced with regard to issues such as rationalism, science, the autonomy of the subject, and authorship. But the ambivalent relationship of Lewis to spiritually-oriented, affirmative postmodernism, and particularly Rudolf Steiner's Anthroposophy, is also analysed. The crucial role of Scholasticism in the development of Western thought is investigated in a comparison of Steiner's views with the Christian position of Lewis. It is concluded that there are grounds to regard Lewis as. 'prophet of postmodernism', and he is compared with Nietzsche and Pope John-Paul II in this regard. / Christian Spirituality, Church History and Missiology / D. Th. (Church History)

Thesis (MPhil)--Stellenbosch University, 2005. / ENGLISH ABSTRACT: Two literary conversion narratives with much historical detail, are compared in this thesis: the Confessiones written by the renowned fourth century church-father, St. Augustine, and Surprised by Joy written by the twentieth century writer and scholar, C.S. Lewis. In order to understand St. Augustine's conversion to the Christian faith, Christian religion as a social phenomenon in the Ancient World is discussed. As background for the discussion and comparison of the two conversion narratives, a brief biography is given of St. Augustine and of Lewis, as well as a description of each one's course of conversion. The research is structured In terms of beacons that St. Augustine identified during the course of his conversion: people who played a significant role, events that influenced his life, and inner conflict that spurred him on his way. By means of an analysis regarding theme and content, it is shown that there are clear similarities between the beacons identified by Augustine and Lewis in their conversion narratives. / AFRIKAANSE OPSOMMING: In hierdie tesis word twee literêre bekeringsverhale waarin die historiese werklikheid deur die skrywers weergegee word, met mekaar vergelyk: die Confessiones van die vierde eeuse kerkvader Augustinus, en Surprised by Joy van die twintigste eeuse skrywer en geleerde C.S. Lewis. Om Augustinus se bekeringsverhaal histories te kan plaas teen die agtergrond waarin hy geleef en tot bekering gekom het, word 'n uiteensetting gegee van die Christelike godsdiens as 'n sosiale fenomeen in die Antieke Wêreld. 'n Kort lewensbeskrywing van Augustinus en Lewis en 'n oorsig van die weg wat elkeen se bekering gevolg het, dien as agtergrond vir die bespreking en vergelyking van die twee bekeringsverhale. Die navorsing word gestruktureer aan die hand van bakens wat Augustinus op sy bekeringsweg uitgelig het: persone wat 'n beduidende rol gespeel het, gebeure wat hom beïnvloed het, innerlike konflik wat hom voortgedryf het. Die tesis toon deur 'n analise op grond van inhoud en tematiek aan dat daar duidelike ooreenkomste is tussen die bakens op Augustinus se bekeringsweg en dié op Lewis se bekeringsweg.

The 'postmodern challenge' is increasingly felt in the 'end of modernity' to which Gianni Vattimo refers. The West and the world has hitherto been dominated by what Andrew Gamble characterises as the Modern or Western Ideology. But the validity of that worldview and its associated ways of thinking, going back to the 'Enlightenment' and beyond, has come to be radically questioned. It is within this context that the work and thought of CS Lewis is examined. Although Lewis is generally recognised, and regarded himself, as conservative and even reactionary, there is a paradoxical quality to his conservatism, the elements of which coexist with features which might be regarded as liberal and as radically socialist respectively. Similarly, his commitment to the religious and cultural tradition of Western Europe co-exists with a vehement anticolonialism. A paradoxical association of postmodermism with 'premodernity' has been widely noted in Buddhism and, by Derrida, in Eastern Christian theology. This thesis seeks to demonstrate that a paradoxical postmodernism is evident in the thought of Lewis. One source suggested for this is his interest in Eastern Christianity. Another is identified as the influence on Lewis of the opposition of Romanticism to 'Enlightenment' modernity. But Lewis's own engagement with modernity is also shown to be significant. Two broad trends in postmodernism are discussed. The affinities of Lewis's thought with the nihilistic tradition of postmodernism, going back to Nietzsche, is traced with regard to issues such as rationalism, science, the autonomy of the subject, and authorship. But the ambivalent relationship of Lewis to spiritually-oriented, affirmative postmodernism, and particularly Rudolf Steiner's Anthroposophy, is also analysed. The crucial role of Scholasticism in the development of Western thought is investigated in a comparison of Steiner's views with the Christian position of Lewis. It is concluded that there are grounds to regard Lewis as. 'prophet of postmodernism', and he is compared with Nietzsche and Pope John-Paul II in this regard. / Christian Spirituality, Church History and Missiology / D. Th. (Church History)

In this study, C. S. Lewis's books, essays, stories, and poems, in addition to biographies and essays written about Lewis, were read in an attempt to understand the relationship between Lewis's spiritual quest and his total health. The spiritual quest is defined as the search for the ultimate truth and meaning of life. For Lewis, who was a Christian, the quest for the Spirit is a journey toward God-Jesus-the Holy Spirit. Health is defined as total experience; the interrelationship of the body, mind, and spirit with all there is, has been, and will be. Health is considered a changing perception, not a fixed state. The dimensions of Lewis's health—physical, psychological, social, and spiritual—are studied. Lewis's physical states, literary works, literary themes, friendships, ethics, marriage, and views on religion are considered as each relates to his determination to know and to love God. For Lewis, anything without God is nothing. God is the creator of all living things and all matter. He is the inventor of all loves and is Love. In Lewis's opinion, one's health is in direct proportion to one's love for God. When man loves God he is healthy, the more he loves Him the healthier, the less he loves Him the less healthy.

Thesis (MPhil)--Stellenbosch University, 2014. / ENGLISH ABSTRACT: The Chronicles of Narnia by C.S. Lewis is internationally considered as one of the classics of children’s literature. The series consists of seven books, of which only the first four were translated into Afrikaans, namely Die Towenaar se Neef (The Magician’s Nephew), Die Leeu, die Heks en die Hangkas (The Lion, the Witch and the Wardrobe), Die Perd en sy Seun (The Horse and his Boy) and Prins Kaspian (Prince Caspian). According to the publisher, Human & Rousseau, they have no intention to translate the remainder of the series. The three books that have not been translated into Afrikaans are The Voyage of the Dawn Treader, The Silver Chair and The Last Battle. The main aim of this study is the practical translation of a selection of The Voyage of the Dawn Treader. The Functionalist approach of Vermeer and Nord, Toury and Chesterman’s translation norms from Descriptive Translation Studies, Venuti’s foreignisation and domestication and Klingberg’s cultural contex adaptation form the theoretical framework for both the discussion and analysis of the source text as well as the translation. The four types of translation problems as identified by Nord are used as the framework for the annotations of the translation. By doing a theoretically based translation, the connection between theory and practice is illustrated: the translator chooses a general approach and translation strategies and is consequently guided to make consistent translation choices on macro as well as micro levels. / AFRIKAANSE OPSOMMING: C.S. Lewis se Chronicles of Narnia beklee internasionaal ’n gevestigde plek in die kanon van kinder- en jeugliteratuur. Die reeks bestaan uit sewe boeke, waarvan slegs die eerste vier in Afrikaans vertaal is, naamlik Die Towenaar se Neef, Die Leeu, die Heks en die Hangkas, Die Perd en sy Seun en Prins Kaspian. Volgens die uitgewer, Human & Rousseau, word daar nie verdere vertalings van die reeks beoog nie. Die drie onvertaalde boeke in die reeks is The Voyage of the Dawn Treader, The Silver Chair en The Last Battle. Hierdie studie fokus hoofsaaklik op die praktiese vertaling van ’n gedeelte van The Voyage of the Dawn Treader. Vermeer en Nord se Funksionalisme, Toury en Chesterman se vertaalnorme uit Deskriptiewe Vertaalstudies, Venuti se vervreemding en domestikering en Klingberg se kulturele konteksaanpassing dien as teoretiese raamwerk vir sowel die bespreking en ontleding van die bronteks as die vertaling. Nord se vier tipes vertaalprobleme dien as raamwerk vir die annotasies tot die vertaling. Deur ’n teoreties gebaseerde vertaling te doen word geïllustreer hoe teorie en praktyk by mekaar aansluit: die vertaler kies ’n algemene benadering en vertaalstrategieë, en word sodoende begelei tot konsekwente vertaalbesluite op makro- en mikrovlak.