Orientadora: Profa. Dra. Léia Bernardi Bagesteiro / Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Neurociência e Cognição, 2014. / A maioria das amputações traumáticas do membro superior ocorre em níveis do punho e da mão. O uso de sinais bioelétricos, como os capturados pela eletromiografia de músculos residuais no segmento mão-braço amputado, já é uma realidade, porém as taxas de rejeição das próteses mioelétricas ainda são elevadas. Um dos maiores desafios atuais é melhorar o desempenho das próteses robóticas a fim de que a interface homem-máquina seja o mais natural possível. O presente estudo teve por objetivo avaliar a intensidade elétrica dos músculos residuais do coto durante movimentos do segmento mão-braço de indivíduos amputados de membro superior. Foram caracterizados diferentes movimentos-alvo a fim de auxiliar no conhecimento da ação muscular após amputação. Oito canais de eletromiografia foram posicionados no membro superior e coto: quatro no braço e quatro no antebraço. Nove movimentos-alvo contínuos foram realizados duas vezes em cada uma das duas séries de movimentos avaliadas. Foram analisados o coto (grupo experimental membro amputado), o membro contralateral à amputação (grupo experimental membro não amputado) e um grupo controle. Todos os grupos apresentaram as mesmas etapas de coleta, desde o posicionamento dos eletrodos até a análise do sinal eletromiográfico. Os dados foram comparados para maior compreensão dos movimentos do membro superior nesses grupos. Os resultados apresentaram diferença entre os grupos. A musculatura de braço teve maior intensidade de ativação elétrica no grupo controle. Por sua vez, o grupo experimental membro amputado teve maior intensidade de ativação em musculaturas extensoras e maior diferenciação dos canais do antebraço. Contudo, o grupo experimental membro não amputado foi o que mais se diferenciou nas diferentes análises, sendo observado menor intensidade de ativação elétrica no braço e antebraço. Conclui-se que a intensidade de ativação dos músculos residuais do coto difere do membro não amputado. / Most traumatic upper-limb amputations occur at the wrist and hand levels. Bioelectric signals, such as the ones captured by electromyography at the amputated hand-arm segment are already a reality, yet rejection rates of myoelectric prostheses are still high. The main challenge is to improve the performance of robotic prostheses enabling a more natural man-machine interface. This study evaluated the electrical magnitude of residual muscles during hand-arm movements of upper limb amputee. Different movements were chosen to promote muscle activation knowledge after amputation. Eight electromyography channels were positioned on the upper-limb and stump: four at the upper arm and four at the forearm. Nine continuous movements were performed twice on each of the two series evaluated. Three groups were analyzed: amputee group (experimental group: amputated limb), contralateral limb amputation (experimental group: non-amputated limb) and control group. All groups had the same data collection phases, electrodes positioning and eletromyographic signals analysis. Data were compared for better understanding of upper limb movements. The results showed difference between groups. The upper arm muscles had greater magnitude of electrical activation in the control group. The experimental group: amputated limb had greater magnitude of electrical activation in the extensor musculature and greater difference from the forearm channels. Moreover the experimental group: non-amputated limb was the most distinguished in comparison with the other two groups on different analyzes, with lower magnitude of electrical activation observed in the upper arm and forearm. It is concluded that the magnitude of activation of the residual muscles in the amputated limb differs from non-amputated limb.

Yes / Introduction: Clinicians typically use findings from cohort studies to objectively inform judgements regarding the potential (dis)advantages of prescribing a new prosthetic device. However, before finalising prescription a clinician will typically ask a patient to ‘try out’ a change of prosthetic device while the patient is at the clinic. Observed differences in gait when using the new device should be the result of the device’s mechanical function, but could also conceivably be due to patient related factors which can change from day-to-day and can thus make device comparisons unreliable. To determine whether a device’s mechanical function consistently has a more meaningful impact on gait than patient-related factors, the present study undertook quantitative gait analyses of a trans-tibial amputee walking using two different foot-ankle devices on two occasions over a year apart. If the observed differences present between devices, established using quantitative gait analysis, were in the same direction and of similar magnitude on each of the two occasions, this would indicate that device-related factors were more important than patient-related factors. Methods: One adult male with a unilateral trans-tibial amputation completed repeated walking trials using two different prosthetic foot devices on two separate occasions, 14 months apart. Walking speed and sagittal plane joint kinematics and kinetics for both limbs were assessed on each occasion. Clinically meaningful differences in these biomechanical outcome variables were defined as those with an effect size difference (d) between prosthetic conditions of at least 0.4 (i.e. ‘medium’ effect size). Results: Eight variables namely, walking speed, prosthetic ‘ankle’ peak plantar- and dorsi- flexion and peak positive power, and residual knee loading response flexion, peak stance-phase extension and flexion moments and peak negative power, displayed clinically meaningful differences (d > 0.4) between foot devices during the first session. All eight of these showed similar effect size differences during the second session despite the participant being heavier and older. Conclusions: Findings suggest that a prosthetic device’s mechanical function consistently has a more meaningful impact on gait than patient-related factors. These findings support the current clinical practice of making decisions regarding prosthetic prescription for an individual, based on a single session evaluation of their gait using two different devices. However, to confirm this conclusion, a case series using the same approach as the present study could be undertaken.

<p>The high prevalence of diabetes mellitus among the Sudanese population is linked to obesity, poor glycaemic control and a high rate of complications. This study investigated 1/ Leptin hormone and its correlations with different biochemical characteristics in Sudanese diabetic subjects, 2/ The impact of glycaemic control on pregnancy outcome in pregnancies with diabetes, 3/ The glycaemic response to Sudanese traditional carbohydrate foods, 4/ The influence of glucose self-monitoring on the glycaemic control among this population, 5/ The health related quality of life in Sudanese subjects with diabetes-related lower limb amputation. </p><p>Leptin was significantly lower in diabetic subjects compared with controls of same BMI in both females (P =0.0001) and males (P =0.019). In diabetic subjects, serum leptin correlated positively with the homeostatic assessment (HOMA) of both beta-cell function (P =0.018) and insulin resistance (P =.038). In controls, leptin correlated only with insulin resistance. Pregnancy complications were higher among diabetic compared with control women (P<0.0001) and varied with the type of diabetes. Infants of diabetic mothers had a higher incidence of neonatal complications than those of non-diabetic women (P<0.0001). In six Sudanese traditional carbohydrate meals over all differences in incremental AUCs were significant for both plasma glucose (P = 0.0092) and insulin (P = 0.0001). Millet porridge and wheat pancakes displayed significantly lower post-prandial glucose and insulin responses, whereas maize porridge induced a higher post-prandial glucose and insulin response. In type 2 diabetic subjects SMBG or SMUG was not related to glycaemic control. In type 1 diabetic subjects, SMBG was significantly associated with better glycaemic control, as assessed by HbA1c (P=0.02) and blood glucose at clinic visits (P=<0.0001), similar associations were found for SMUG respectively. Neither glycaemic control nor glucose self-monitoring was associated with education level. Diabetic subjects with LLA had significantly poorer HRQL compared to a reference diabetic group (P=<0.0001). Duration of diabetes and amputation had negative impact on HRQL in subjects with LLA (P=<0.0001) respectively. Diabetic subjects with LLA had decreased sense of coherence and high presence of symptoms. Improving health services at the primary level is important to reduce the complications and burden of disease in the Sudanese population.</p>

The high prevalence of diabetes mellitus among the Sudanese population is linked to obesity, poor glycaemic control and a high rate of complications. This study investigated 1/ Leptin hormone and its correlations with different biochemical characteristics in Sudanese diabetic subjects, 2/ The impact of glycaemic control on pregnancy outcome in pregnancies with diabetes, 3/ The glycaemic response to Sudanese traditional carbohydrate foods, 4/ The influence of glucose self-monitoring on the glycaemic control among this population, 5/ The health related quality of life in Sudanese subjects with diabetes-related lower limb amputation. Leptin was significantly lower in diabetic subjects compared with controls of same BMI in both females (P =0.0001) and males (P =0.019). In diabetic subjects, serum leptin correlated positively with the homeostatic assessment (HOMA) of both beta-cell function (P =0.018) and insulin resistance (P =.038). In controls, leptin correlated only with insulin resistance. Pregnancy complications were higher among diabetic compared with control women (P&lt;0.0001) and varied with the type of diabetes. Infants of diabetic mothers had a higher incidence of neonatal complications than those of non-diabetic women (P&lt;0.0001). In six Sudanese traditional carbohydrate meals over all differences in incremental AUCs were significant for both plasma glucose (P = 0.0092) and insulin (P = 0.0001). Millet porridge and wheat pancakes displayed significantly lower post-prandial glucose and insulin responses, whereas maize porridge induced a higher post-prandial glucose and insulin response. In type 2 diabetic subjects SMBG or SMUG was not related to glycaemic control. In type 1 diabetic subjects, SMBG was significantly associated with better glycaemic control, as assessed by HbA1c (P=0.02) and blood glucose at clinic visits (P=&lt;0.0001), similar associations were found for SMUG respectively. Neither glycaemic control nor glucose self-monitoring was associated with education level. Diabetic subjects with LLA had significantly poorer HRQL compared to a reference diabetic group (P=&lt;0.0001). Duration of diabetes and amputation had negative impact on HRQL in subjects with LLA (P=&lt;0.0001) respectively. Diabetic subjects with LLA had decreased sense of coherence and high presence of symptoms. Improving health services at the primary level is important to reduce the complications and burden of disease in the Sudanese population.

Title: Assessment of the effect of CDP training in patient after lower extremity amputation Objectives: The aim of this diploma thesis is to describe the influence of the individually set training programme on the computerized dynamic posturography (CDP) NeuroCom Smart EquiTest System (further referred to as EquiTest) independent of traditional therapeutic exercises in the patient after unilateral transfemoral amputation of the lower limb and to monitor the effect of this training on postural behaviour, ability of functional mobility and balance, frequency of falls and balance confidence in an individual after amputation. Methods: This is an experimental pilot case study that monitors the effect of an individually designed five-week training programme (with a frequency of exercises 2 times a week) on the EquiTest in one patient after unilateral transfemoral amputation of the lower limb. Examination of postural functions was performed by the EquiTest using SOT, MCT, and LOS tests. The ability of functional mobility and balance was tested using the functional Timed up and go test (TUG). The frequency of falls was detected from the proband's medical history. The balance confidence was determined using the Activities specific balance confidence scale (ABC). All measurements were made in two terms, i.e....

Aim: The aim of this thesis is to evaluate patients’ satisfaction with prosthetic device and service on lower limb amputations in Danang, Vietnam and to implement comparisons between the subgroups gender, living area, amputation cause and level. Method: A cross-sectional study design was conducted using the Quebec User Evaluation of Satisfaction with assistive Technology (QUEST) 2.0 questionnaire to measure patients’ satisfaction. Fifty patients were recruited through the International Committee of the Red Cross (ICRC) and the data collection was performed in the patients own homes with an interpreter. The collected data was statistically analyzed with suitable tests using Statistical Package for the Social Sciences (SPSS). Result: The patients were quite satisfied with their prosthetic devices (mean 4.16 SD ± 0.561) and more or less satisfied with their given services (mean 2.83 SD ± 1.213). Significant differences were found between genders regarding the patients’ satisfaction with prosthetic device. There were no significant differences between the remaining subgroups; living area, amputation cause and amputation level. Conclusion: This thesis demonstrates that the patients in Danang appear to be quite satisfied with their prosthetic device, even though they reported problems with the durability of the device. Furthermore, the patients were more or less satisfied with their prosthetic services. The findings in this thesis also reveals that women were less satisfied compared to men regarding the prosthetic device. These conclusions should however be taken with caution, since the reliability and validity was lower than desired and it’s difficult to generalize the results to the population. / Syfte: Syftet med denna studie är att evaluera patienters nöjdhet med deras utgivna protes och service på nedre extremitetsamputerade i Danang, Vietnam och att implementera jämförelser mellan subgrupperna kön, bostadsområde, amputations- orsak och nivå. Metod: En cross-sectional studiedesign blev utförd genom användning av Quebec User Evaluation of Satisfaction with assistive Technology (QUEST) 2.0 enkäten för att mäta patienters nöjdhet. Femtio patienter blev rekryterade genom International Committee of the Red Cross (ICRC) och datainsamlingen blev utförd i patienternas egna hushåll med en tolk. Den insamlade datan blev statistiskt analyserad med lämpliga tester genom användning av Statistical Package for the Social Sciences (SPSS). Resultat: Patienterna var ganska nöjda med deras utgivna proteser (medelvärde 4,16 SD ± 0,561) och mer eller mindre nöjda med deras utgivna service (medelvärde 2,83 SD ± 1,213). Signifikanta skillnader hittades mellan kön gällande patienters nöjdhet med deras utgivna protes. Det fanns inga signifikanta skillnader mellan de resterande subgrupperna; bostadsområde, amputationsorsak och amputationsnivå. Slutsats: Den här studien demonstrerar att patienterna i Danang verkar vara ganska nöjda med deras utgivna proteser, fastän de rapporterade problem med protesens hållbarhet. Dessutom var patienterna mer eller mindre nöjda med deras utgivna service. Fynden i denna studie påvisar också att kvinnorna var mindre nöjda gällande protesen jämfört med männen. Dessa slutsatser skall dock tas med aktsamhet, eftersom reliabiliteten och validiteten blev lägre än önskat och det var svårt att generalisera resultaten till populationen.

Background: The number of people with diabetes is rising globally, and they are at higher risk of foot complications that can ultimately result in lower limb amputation. Additionally, individuals with diabetes whoundergo amputation are more likely to lose the contralateral limb. Consistent care and preventive measuresare crucial for reducing the risk of further amputations. Aim: This study aims to explore the current experience of certified prosthetist and orthotist in Denmarkconcerning the assessment of the contralateral limb in individuals with diabetes who utilize a lower limbprosthesis. Method: A qualitative study with an exploratory research design was conducted. Thematic analysis, using aninductive approach was employed to analyze data from eight semi-structured interviews with CPOs from Denmark. Findings: The analysis of the interview results revealed three main themes - responsibility, prioritization,and barriers - which frequently overlap. Each theme had multiple sub-themes which highlights the variationin the participants’ experiences. Conclusion: The variation in responses gathered from the interviews unveiled diverse perspectives on responsibility, prioritization, and barriers which points to a lack of clear guidelines in the Danish healthcaresystem regarding this assessment of the contralateral limb in this patient group. This study offers novel insightsinto the diverse experiences and decision-making processes of Danish CPOs when it comes to the contralaterallimb assessment in diabetic foot care. / <p></p><p></p>

This diploma thesis deals with the topic of clients after lower limb/s amputation and their social rehabilitation afterwards in home care. Beginning of thesis describes the current situation and the concept of social rehabilitation as one of the comprehensive rehabilitation process of people in early post-amputation stage. Next section of thesis shows difficulties that occurs after amputation and impact upon personal life that is materially changed. Describing the process of coping with this unpleasant health change is based on traditional model of two important people in this field Mr. Kübler-Ross and Mr. Křivohlavý. At the same time, analysis of the formal support system in Ústí nad Labem is being evaluated. This system provides support not only to disabled people but also to people who take infromal care of the one injured. Informal care plays significant role in the process of social rehabilitation of people starting new life stage due to physical change. In thesis are mentioned possibilities of developing skills of informal caregivers, usage of financial benefits for disabled people and possible providers support of medical and social services in a given location. However, it also focuses on possible troubles associated with care provided by family members or other persons. At the same time,...

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