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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

A biomarker survey of the fatty acid status of New Zealanders

Crowe, Francesca Lee, n/a January 2006 (has links)
My thesis research has examined the fatty acid composition of serum triacylglycerol, phospholipid and cholesterol ester in 2793 participants who took part in the 1997 National Nutrition Survey - a national population-based survey of New Zealand adolescents and adults aged or [greater than or equal to]̲15 y. Differences in serum fatty acids by sex, age, ethnicity, body mass index and smoking - independent of dietary fat intake - were determined. Serum fatty acids were used as biomarkers of saturated and polyunsaturated fat intake to predict population serum total cholesterol concentrations. The association between n-3 long-chain polyunsaturated fatty acids in serum phospholipid and mental and physical wellbeing, as assessed by the short form-36, was determined. Serum fatty acids have been used as biological markers of fat intake and to predict the risk of disease. The fatty acid composition of serum triacylglycerol, phospholipid and cholesterol ester is subject to alteration by dietary fat but overall, is largely controlled by metabolic enzymes. Non-dietary variables - sex, age, body mass index or cigarette smoking - may influence the activity of these enzymes, which will subsequently alter the fatty acid composition but the extent to which these affect serum fatty acid composition in the general population is poorly understood. Our results showed that the proportion of docosahexaenoic acid in serum phospholipid and cholesterol ester was significantly greater in women by 0.15 and 0.02 mol%, respectively in comparison to men whereas, the proportion of eicosapentaenoic acid was significantly greater in men by 0.08 and 0.1 mol%, respectively, after adjusting for age, ethnicity, body mass index and smoking. A number of differences in the proportion of palmitoleic acid in serum triacylglycerol, phospholipid and cholesterol ester were detected; palmitoleic acid increased across the age categories in women (15-24, 25-44, 45-64 65+ y), was higher in women compared to men, New Zealand Europeans compared to New Zealand Maori and Pacific People, those with a body mass index or [greater than or equal to] 30 kg/m� compared to those with a body mass index < 25 kg/m� and in current smokers in comparison to non-smokers. In women, there was an inverse trend in the proportion of linoleic acid in serum phospholipid and cholesterol ester across the age categories. The proportion of linoleic acid in serum triacylglycerol, phospholipid and cholesterol ester was lower in smokers by 2.19, 1.04 and 0.75 mol%, respectively in comparison to non-smokers. None of these differences could be explained by a difference in dietary fat intake. Consequently, sex appears to affect the metabolism of n-3 long-chain polyunsaturated fatty acids independent of dietary fat intake and metabolic differences associated with age, body mass index and smoking may be at play for a number of other serum fatty acids notably, palmitoleic and linoleic acids. Evidence for a role of dietary fat as a predictor of serum cholesterol concentrations in the general population is conflicting. On one hand, results from cholesterol-lowering dietary intervention trials show unequivocally that decreasing saturated fat intake produces a meaningful reduction in serum cholesterol concentrations. On the other hand, the results of large observational studies show little association between saturated fat intake and cholesterol concentrations. The lack of association in the latter studies may result from errors in dietary assessment and therefore, using serum fatty acids as biomarkers of fat intake may overcome the limitations associated with typical dietary assessment techniques. Participants were divided into quintiles of increasing proportion of serum fatty acids. Each one SD increase in the myristic acid composition of serum cholesterol ester, triacylglycerol and phospholipid was associated with an increase in cholesterol of 0.19, 0.10 and 0.13 mmol/L, respectively after adjusting for confounding variables. The difference in cholesterol concentrations between those categorised into the highest and lowest quintiles of serum cholesterol ester myristate was 0.48 mmol/L. A one SD increase in the linoleic acid composition of serum cholesterol ester, triacylglycerol and phospholipid corresponded to a decrease in cholesterol of 0.07, 0.05 and 0.07 mmol/L, respectively. The difference in cholesterol concentrations between the 1st and 5th quintiles of serum cholesterol linoleate was 0.18 mmol/L. Intake of saturated and polyunsaturated fats, as measured using serum fatty acids, are important determinants of cholesterol concentrations in New Zealanders. It has been hypothesised that a lower intake of n-3 long-chain polyunsaturated fatty acids, largely of marine origin, is implicated in the aetiology of depressive disorder. Results from the majority of observational studies have shown that depressed participants have a lower proportion of eicosapentaenoic or docosahexaenoic acid in phospholipids compared to controls but evidence for an improvement in depressive symptoms after supplementation with n-3 long-chain polyunsaturated fatty acids is conflicting. There is little known about the role that n-3 long-chain polyunsaturated fatty acids may have as predictors of mental wellbeing in the general population. Participants were categorised into quintiles of increasing n-3 long-chain polyunsaturated fatty acids in serum phospholipid. There was no significant trend in self-reported mental wellbeing - the mental component score - across the quintiles of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids or the sum of these three fatty acids after adjusting for confounding variables. There was a significant trend in the mental component score across the quintiles of the ratio of eicosapentaenoic/arachidonic acid; the difference between the highest and the lowest quintile was 6.6 points. There were significant positive trends in self-reported physical health - the physical component score - across the quintiles of eicosapentaenoic and docosapentaenoic acids as well as the ratio of eicosapentaenoic/arachidonic acid ratio; the difference between the 1st and 5th quintiles were 8.6, 6.0 and 8.9 points, respectively. Overall, there appears to be little association between the n-3 long-chain polyunsaturated fatty acid composition of serum phospholipid and self-reported mental health in a population of low fish consumers; however, the proportion of n-3 long-chain polyunsaturated fatty acids may be an important predictor of physical wellbeing in New Zealanders.
12

Biogeneration of lipophenols by lipases using selected substrate models

Petel, Tamara January 2003 (has links)
The objective of the research was to carry out the biogeneration of lipophenols by enzymatic esterification of tricaprylin and caprylic acid with catechin and catechol in a model hexane system. Commercial lipases, including Lipase N from Rhizopus niveus, Lipozyme IM from Mucor miehei and Novozym 435 from Candida antarctica were used throughout this study. The effects of reaction time, incubation temperatures and agitation speeds on enzymatic hydrolytic activity were investigated to determine the optimal conditions for biocatalysis. The optimal temperatures for biocatalysis were determined to be 37.5°C for Lipase N, and 55°C for Lipozyme IM and Novozym 435; the optimum agitation speed was 100 rpm. Using Lipase N, maximum hydrolysis of 1.66 mumol free fatty acids/mL was obtained after 1.5 days of incubation, while with Lipozyme IM, maximum hydrolysis of 8.1 and 8.5 mumol free fatty acids/mL was obtained after 1 and 4 days, respectively. With Novozym 435, the highest hydrolysis of 4.0 and 6.1 mumol free fatty acids/mL were found after 2 and 9 days, respectively.
13

A biomarker survey of the fatty acid status of New Zealanders

Crowe, Francesca Lee, n/a January 2006 (has links)
My thesis research has examined the fatty acid composition of serum triacylglycerol, phospholipid and cholesterol ester in 2793 participants who took part in the 1997 National Nutrition Survey - a national population-based survey of New Zealand adolescents and adults aged or [greater than or equal to]̲15 y. Differences in serum fatty acids by sex, age, ethnicity, body mass index and smoking - independent of dietary fat intake - were determined. Serum fatty acids were used as biomarkers of saturated and polyunsaturated fat intake to predict population serum total cholesterol concentrations. The association between n-3 long-chain polyunsaturated fatty acids in serum phospholipid and mental and physical wellbeing, as assessed by the short form-36, was determined. Serum fatty acids have been used as biological markers of fat intake and to predict the risk of disease. The fatty acid composition of serum triacylglycerol, phospholipid and cholesterol ester is subject to alteration by dietary fat but overall, is largely controlled by metabolic enzymes. Non-dietary variables - sex, age, body mass index or cigarette smoking - may influence the activity of these enzymes, which will subsequently alter the fatty acid composition but the extent to which these affect serum fatty acid composition in the general population is poorly understood. Our results showed that the proportion of docosahexaenoic acid in serum phospholipid and cholesterol ester was significantly greater in women by 0.15 and 0.02 mol%, respectively in comparison to men whereas, the proportion of eicosapentaenoic acid was significantly greater in men by 0.08 and 0.1 mol%, respectively, after adjusting for age, ethnicity, body mass index and smoking. A number of differences in the proportion of palmitoleic acid in serum triacylglycerol, phospholipid and cholesterol ester were detected; palmitoleic acid increased across the age categories in women (15-24, 25-44, 45-64 65+ y), was higher in women compared to men, New Zealand Europeans compared to New Zealand Maori and Pacific People, those with a body mass index or [greater than or equal to] 30 kg/m� compared to those with a body mass index < 25 kg/m� and in current smokers in comparison to non-smokers. In women, there was an inverse trend in the proportion of linoleic acid in serum phospholipid and cholesterol ester across the age categories. The proportion of linoleic acid in serum triacylglycerol, phospholipid and cholesterol ester was lower in smokers by 2.19, 1.04 and 0.75 mol%, respectively in comparison to non-smokers. None of these differences could be explained by a difference in dietary fat intake. Consequently, sex appears to affect the metabolism of n-3 long-chain polyunsaturated fatty acids independent of dietary fat intake and metabolic differences associated with age, body mass index and smoking may be at play for a number of other serum fatty acids notably, palmitoleic and linoleic acids. Evidence for a role of dietary fat as a predictor of serum cholesterol concentrations in the general population is conflicting. On one hand, results from cholesterol-lowering dietary intervention trials show unequivocally that decreasing saturated fat intake produces a meaningful reduction in serum cholesterol concentrations. On the other hand, the results of large observational studies show little association between saturated fat intake and cholesterol concentrations. The lack of association in the latter studies may result from errors in dietary assessment and therefore, using serum fatty acids as biomarkers of fat intake may overcome the limitations associated with typical dietary assessment techniques. Participants were divided into quintiles of increasing proportion of serum fatty acids. Each one SD increase in the myristic acid composition of serum cholesterol ester, triacylglycerol and phospholipid was associated with an increase in cholesterol of 0.19, 0.10 and 0.13 mmol/L, respectively after adjusting for confounding variables. The difference in cholesterol concentrations between those categorised into the highest and lowest quintiles of serum cholesterol ester myristate was 0.48 mmol/L. A one SD increase in the linoleic acid composition of serum cholesterol ester, triacylglycerol and phospholipid corresponded to a decrease in cholesterol of 0.07, 0.05 and 0.07 mmol/L, respectively. The difference in cholesterol concentrations between the 1st and 5th quintiles of serum cholesterol linoleate was 0.18 mmol/L. Intake of saturated and polyunsaturated fats, as measured using serum fatty acids, are important determinants of cholesterol concentrations in New Zealanders. It has been hypothesised that a lower intake of n-3 long-chain polyunsaturated fatty acids, largely of marine origin, is implicated in the aetiology of depressive disorder. Results from the majority of observational studies have shown that depressed participants have a lower proportion of eicosapentaenoic or docosahexaenoic acid in phospholipids compared to controls but evidence for an improvement in depressive symptoms after supplementation with n-3 long-chain polyunsaturated fatty acids is conflicting. There is little known about the role that n-3 long-chain polyunsaturated fatty acids may have as predictors of mental wellbeing in the general population. Participants were categorised into quintiles of increasing n-3 long-chain polyunsaturated fatty acids in serum phospholipid. There was no significant trend in self-reported mental wellbeing - the mental component score - across the quintiles of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids or the sum of these three fatty acids after adjusting for confounding variables. There was a significant trend in the mental component score across the quintiles of the ratio of eicosapentaenoic/arachidonic acid; the difference between the highest and the lowest quintile was 6.6 points. There were significant positive trends in self-reported physical health - the physical component score - across the quintiles of eicosapentaenoic and docosapentaenoic acids as well as the ratio of eicosapentaenoic/arachidonic acid ratio; the difference between the 1st and 5th quintiles were 8.6, 6.0 and 8.9 points, respectively. Overall, there appears to be little association between the n-3 long-chain polyunsaturated fatty acid composition of serum phospholipid and self-reported mental health in a population of low fish consumers; however, the proportion of n-3 long-chain polyunsaturated fatty acids may be an important predictor of physical wellbeing in New Zealanders.
14

Soy isoflavone bioavailability effects of probiotic and prebiotic consumption and oil supplementation /

Larkin, Theresa Anne. January 2005 (has links)
Thesis (Ph.D.)--University of Wollongong, 2005. / Typescript. Includes bibliographical references: leaf 279-310.
15

Relationship of meal planners' nutrition attitudes and knowledge to their fat and fiber intakes and that of their preschool-aged children /

Colavito, Elizabeth A. January 1994 (has links)
Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1994. / Vita. Abstract. Includes bibliographical references (leaves 75-81). Also available via the Internet.
16

Regulation of cholesterol ester transfer protein by dietary lipids /

Murray, Cathy Maureen, January 2003 (has links)
Thesis (M.Sc.)--Memorial University of Newfoundland, 2003. / Bibliography: leaves 92-107. Also available online.
17

Lipids in supercritical carbon dioxide physical functional aspects /

Hammam, Hagar. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.
18

Lipids in supercritical carbon dioxide physical functional aspects /

Hammam, Hagar. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.
19

Biogeneration of lipophenols by lipases using selected substrate models

Petel, Tamara January 2003 (has links)
No description available.
20

Effects of Dietary Fats on Alcohol-Induced Liver Injury : A FT-IR Study

Fotouhinia, Maryam January 1995 (has links)
No description available.

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