Global ETD Search

21	Hibernoma – two patients with a rare lipoid soft-tissue tumour Daubner, Dirk, Spieth, Stephanie, Pablik, Jessica, Paulus, Tobias, Laniado, Michael, Zöphel, Klaus 24 July 2015 (has links) (PDF) Background: Hibernomas are rare benign soft-tissue tumours arising from brown fat tissue. Although imaging characteristics are not specific certain imaging features, common locations and patient demographics may suggest hibernoma as a differential diagnosis. Case presentation: We report on two 48-year-old male patients with hibernoma. The tumour presented with local swelling of the inguinal region in the first patient and was an incidental imaging finding in the second patient. Imaging included magnetic resonance imaging in both patients and computed tomography as well as 18 F-fluorodeoxyglucose positron emission tomography-computed tomography in the second patient. In both cases histological diagnosis was initially based on excisional and needle core biopsy, respectively. Complete surgical resection confirmed the diagnosis of hibernoma thereafter. Conclusion: In soft tissue tumours with fatty components hibernoma may be included into the differential diagnosis. Because of the risk of sampling errors in hibernoma-like tissue components of myxoid and well-differentiated liposarcoma, complete resection is mandatory. This article also reviews the current imaging literature of hibernomas. Hibernoma Fettgewebe Weichteiltumor TU Dresden Publikationsfonds Hibernoma Brown fat tissue Soft-tissue tumour Liposarcoma MRI 18 F-FDG-PET/CT Technical University Dresden Publication funds ddc:610 rvk:XA 10000
22	Hibernoma – two patients with a rare lipoid soft-tissue tumour Daubner, Dirk, Spieth, Stephanie, Pablik, Jessica, Paulus, Tobias, Laniado, Michael, Zöphel, Klaus 24 July 2015 (has links) Background: Hibernomas are rare benign soft-tissue tumours arising from brown fat tissue. Although imaging characteristics are not specific certain imaging features, common locations and patient demographics may suggest hibernoma as a differential diagnosis. Case presentation: We report on two 48-year-old male patients with hibernoma. The tumour presented with local swelling of the inguinal region in the first patient and was an incidental imaging finding in the second patient. Imaging included magnetic resonance imaging in both patients and computed tomography as well as 18 F-fluorodeoxyglucose positron emission tomography-computed tomography in the second patient. In both cases histological diagnosis was initially based on excisional and needle core biopsy, respectively. Complete surgical resection confirmed the diagnosis of hibernoma thereafter. Conclusion: In soft tissue tumours with fatty components hibernoma may be included into the differential diagnosis. Because of the risk of sampling errors in hibernoma-like tissue components of myxoid and well-differentiated liposarcoma, complete resection is mandatory. This article also reviews the current imaging literature of hibernomas. info:eu-repo/classification/ddc/610 ddc:610
23	mdm2 Amplification in NIH3T3L1 Preadipocytes Leads to Mdm2 Elevation in Terminal Adipogenesis Litteral, Vaughn 23 July 2008 (has links) No description available. Biochemistry Biology Biomedical Research Cellular Biology Molecular Biology Oncology mdm2 mdm-2 Rb retinoblastoma p53 cancer adipogenesis liposarcoma adipose oncogene C/EBP tumor suppressor NIH3T3L1 NIH3T3-L1 NIH3T3 amplification chromosomal amplification Southern Northern Western immunoprecipitation mdm4 mdmX
24	Investigating the Effects of Mutant FUS on Stress Response in Amyotrophic Lateral Sclerosis: A Thesis Kaushansky, Laura J. 14 August 2015 (has links) During stress, eukaryotes regulate protein synthesis in part through formation of cytoplasmic, non-membrane-bound complexes called stress granules (SGs). SGs transiently store signaling proteins and stalled translational complexes in response to stress stimuli (e.g. oxidative insult, DNA damage, temperature shifts and ER dysfunction). The functional outcome of SGs is proper translational regulation and signaling, allowing cells to overcome stress. The fatal motor neuron disease Amyotrophic Lateral Sclerosis (ALS) develops in an age-related manner and is marked by progressive neuronal death, with cytoplasmic protein aggregation, excitotoxicity and increased oxidative stress as major hallmarks. Fused in Sarcoma/Translocated in Liposarcoma (FUS) is an RNA-binding protein mutated in ALS with roles in RNA and DNA processing. Most ALS-associated FUS mutations cause FUS to aberrantly localize in the cytoplasm due to a disruption in the nuclear localization sequence. Intriguingly, pathological inclusions in human FUSALS cases contain aggregated FUS as well as several SG-associated proteins. Further, cytoplasmic mutant FUS incorporates into SGs, which increases SG volume and number, delays SG assembly, accelerates SG disassembly, and alters SG dynamics. I posit that mutant FUS association with stress granules is a toxic gain-of-function in ALS that alters the function of SGs by interaction with SG components. Here, I show that mutant FUS incorporates in to SGs via its Cterminal RGG motifs, the methylation of which is not required for this localization. Further, I identify protein interactions specific to full-length mutant FUS under stress conditions that are potentially capable of interacting with FUS in SGs. Finally, I demonstrate a potential change in the protein composition of SGs upon incorporation of mutant FUS. These findings advance the field of ALS and SG biology, thereby providing groundwork for future investigation. stress granules Mutant FUS Amyotrophic Lateral Sclerosis ALS Theses, UMMS Stress, Physiological Cytoplasmic Granules Oxidative Stress RNA-Binding Protein FUS Cell Biology Cellular and Molecular Physiology Molecular and Cellular Neuroscience Molecular Biology Nervous System Diseases

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