Structures deform at high strain rates and temperatures when exposed to impulsive loads. To accommodate the macro change there are microstructural changes that occur, i.e., grain morphology and shear banding. Most studies report on macroscopic response, i.e., large inelastic deformation and tearing of the structure, while limited studies have reported on microscopic changes that develop in the structure. The microstructure is directly related to the mechanical properties and performance of the material. Therefore, understanding the effect of high strain rate loadings on the microstructural evolution and subsequent mechanical properties of metals and alloys is necessary for mechanical design. The main objective of this research was to investigate microstructural changes to characterise the strain distribution and plastic deformation, owing to impulsive loading. Features within the microstructure that could be used to characterise deformation included grain size morphology changes, the presence of shear bands and sub-grain networks. The electron backscatter diffraction (EBSD) technique, which used Kikuchi patterns to characterise the strain distribution in the crystal of the deformed material, was also used as a characterisation tool. The first step in the experimental procedure was to select the appropriate material to investigate these microstructural changes. There was also the systematic investigation into the use of single and double heat treatments. These were used to achieve a large equiaxed grain structure, which was desirable from a microstructural point of view but was not desirable for blast-resistant material selection. The two-step heat treatment was concluded to be the most suitable heat treatment for the annealing and homogenisation of the AISI 430 stainless steel plates. The AISI 430 stainless steel plates used were 244 mm by 244 mm in size and had a circular exposed area of 106 mm. These plates were subjected to repeated explosive blasts, using a plastic explosive (PE4). The charge mass was varied for each test and the stand-off distance was kept constant at 150 mm for uniform loads and 13 mm for localised loads. Two plates were selected to investigate the uniform loading scenario. The first plate, a torn plate, used a charge mass of 30 g and one blast and the second plate, an inelastically-deformed plate, used a charge mass of 10 g and was exposed to three blasts. These two plates offered the same overall charge load with a different strain path. A further two plates were chosen for the investigation into the localised loading scenario. One plate, a petalled plate, used a 6 g charge mass and was exposed to two blasts and the second plate, an inelastically-deformed plate, used a 5 g charge mass and was also exposed to two blasts. The latter two plates offered an investigation into the effect of an increased charge load, where charge load affected the strain rate of the deformation resulting from the blast load. All four plates were sectioned across the midline of the dome and then ground and polished to a mirror finish, using OP-S. The polished samples were analysed, using optical microscopy and EBSD. In addition, Vickers hardness tests were carried out along the midline of the sectional plate profiles, in order to evaluate the extent of strain hardening. All the plates showed either a response of inelastically deforming or of complete or partial tearing failures when subjected to blast loads. For inelastic deformation failures, a global dome was characteristic of the uniform loading condition and an inner dome superimposed by the global dome was characteristic of the localised loading condition. Variation of charge mass and the number of blasts showed an increasing linear relationship between the impulse and midpoint deflection. The macrostructure showed a large variation of failures in the localised condition. The microstructural characterisation results produced micrographs showing regions of long, flat grains with multiple sub-grain networks, indicating deformed microstructures of the blast loaded plates. Parts of the microstructures displayed equiaxed/recrystallised grains characteristic of restoration processes, owing to high temperatures. Vickers hardness tests indicated an increase in material hardness as the number of blasts was increased, with a maximum hardness in the central region of the plates. In the first investigation, into uniform loading, the material characterisation results, combined with the fractography results, indicated brittle failure modes typical of high strain rate failures in strain rate sensitive materials, such as the chosen AISI 430 stainless steel plates. In the second investigation, into localised loading, the material characterisation results, combined with the fractography results, indicated a more ductile failure, owing to a 1 g incremental increase of charge mass, which confirmed the strain rate sensitivity of this material.

Background: Knee osteoarthritis (OA) is a prevalent disease that contributes to lower limb immobility and pain resulting in lost productivity in the work place. Repetitive loading of the knee joint, particularly in occupational settings, significantly increases OA risk. However, rest may promote tissue recovery and increase tissue tolerance to load. Therefore rest should be examined as a mechanism to prevent the development of knee OA. Purpose: The primary objective was to determine if rest can mitigate mechanical deformation of the stifle (knee) joint and articular cartilage damage during loading compared to an unloaded control in an intact porcine stifle model. Methods: A randomized controlled trial was conducted. Among 18 pairs of porcine hind limbs, one limb in each pair was randomly assigned to receive a loading intervention; while the matched pair served as control. Stifles in both groups were dissected, mounted into the loading apparatus, and pre-loaded. Intervention joints were then randomized into one of three loading protocols: no rest, 3:2 work:rest, and 1:1 work:rest; all of these protocols exposed joints to the same amount of cumulative load. Following loading, all joints were dissected to expose the cartilage. Cartilage damage was scored on a categorical scale. Deformation and energy dissipation were calculated for intervention limbs from data obtained from the loading apparatus. Results: Rest did not mitigate displacement or energy dissipation in the stifles exposed to loading. Rest was associated with reduced cartilage damage scores in the lateral femur in the 1:1 condition. Conclusion: Rest had little impact on joint mechanics and cartilage damage in this model. The small sample size may explain these results. Future investigations involving larger samples should assess if longer periods of rest are need to minimize joint damage as a result of loading. / Thesis / Master of Science (MSc) / Repetitive loading of the knee joint is linked to breakdown of knee cartilage leading to the development and progression of knee osteoarthritis (OA). For example, over-exposure to physically demanding tasks in the workplace (i.e. squatting, bending, lifting etc.) increases knee OA risk. However, it is possible that rest breaks can prevent cartilage damage by allowing the tissue to recover and maintain proper function. Therefore, the purpose of this work was to determine the influence of rest on knee joint mechanics and cartilage quality by repetitively loading pig knee joints and exposing them to varying periods of rest. Rest up to sixty seconds did not allow for tissue recovery, nor did it assist with joint function. This work suggests that longer periods of rest may be required to mitigate the damaging effects of loading, or that rest may not mitigate the effects of loading at all.

Cylindrical shells are used for a variety of engineering applications such as undersea vehicles and aircraft. The models currently used to determine the vibration characteristics of these shells are often approximated by assuming the shell is infinitely long or has shear-diaphragm boundary conditions. These models also ignore complex loading conditions such as plane waves in favor of point forces or free vibration models. This work expands on the capabilities of these models by examining the acoustic response of a finite length cylinder with flat plate endcaps to multiple types of distributed loading conditions. Starting with the Donnell equations of motion for thin cylinders and the classical plate theory equations of motion for the endcaps, spacial domain displacement field solutions for the shell and plates take an assumed form that includes unknown wave propagation coefficients. These solutions are substituted into stress boundary conditions and continuity equations evaluated at the intersections between the shell and plates. An infinite summation is contained within the boundary conditions and continuity equations which is decoupled, truncated, and compiled in matrix form to allow for the propagation coefficients to be found via a convergent sum of vectors. System responses due to a ring loading and multiple cases of plane waves are studied and validated using a finite element analysis of the system. It is shown that the analytical model matches the finite element model well. / Master of Science

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Indiana University-Purdue University Indianapolis (IUPUI) / Skeletal fractures due to bone disease impact an estimated 1.5 million Americans per year, creating a large economic burden on our society. Treatment of bone diseases prior to fracture often involves bisphosphonates (current gold-standard in osteoporosis care and prevention). Although bisphosphonates decrease fracture incidence, they often improve bone mass without regard for bone quality. Thus, although bisphosphonates increase the amount of bone present, the inherent bone material strength often decreases, creating a trade-off that increases the risk of atypical fractures after long-term use. This trade-off demonstrates the need for a treatment that targets both bone quality AND quantity. Although bone quality is important, the components of bone that contribute to bone quality are incompletely understood, making it difficult to create new pharmacological agents. With this in mind, my particular area of interest is in understanding how mechanical stimuli protects the formation of bone, leading to improved bone quality. Initially, this area was explored through use of tibial loading in a disease mouse model (osteolathyrism, induced by injection of beta-aminoproprionitrile) as a means of assessing how the body is able to compensate for decreased bone quality. The results of the BAPN and tibial loading studies indicated that injecting mice with BAPN may not be the ideal method to induce osteolathyrism. However, other intriguing results from the BAPN studies then led us into an exploration of how tibial loading itself contributes to bone quality.

Climate change is predicted to have many diverse effects on freshwater lakes and reservoirs by increasing both hypolimnetic hypoxia and runoff, which will increase nutrient concentrations and degrade water quality. Hypoxic conditions can trigger the release of metals and nutrients from the sediments, i.e., internal loading, while storms can increase external nutrient loading to a waterbody. One potential solution for combating hypoxia is to use side stream supersaturation (SSS), a novel form of hypolimnetic oxygenation. First, in Chapter 1, I tested the efficacy of SSS operation to improve water quality in Falling Creek Reservoir (FCR), a shallow, eutrophic, drinking water reservoir. I found that SSS operation successfully increased hypolimnetic oxygen concentrations in FCR and suppressed internal loading of iron, manganese, and phosphorus. In Chapter 2, I manipulated inflow volumes to FCR and used SSS as a tool to alter hypolimnetic oxygen conditions in whole-ecosystem manipulations of internal and external nutrient loading. I observed that internal nitrogen and phosphorus loading during hypoxic conditions largely controlled the hypolimnetic mass of nutrients in FCR, regardless of inflow volumes, presumably as a result of the accumulated nutrients in its sediment from historical agriculture. Additionally, FCR consistently functioned as net sink of N and P throughout almost all of the treatments and substantially reduced nutrient export to downstream ecosystems. In summary, my research demonstrates the sensitivity of reservoir water quality to global change. / Master of Science

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