Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1982. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING / Bibliography: leaf 60. / by Susan Russell Stapleton. / B.S.

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Thesis (M.S.) -- Mississippi State University. Department of Mechanical Engineering. / Title from title screen. Includes bibliographical references.

Future management of helicopter fleets will be more heavily based on individual component damage tracking and less on legacy usage monitoring (flight parameter-based) methods. This enhances health assessment capabilities by taking into account the actual loads on a component-by-component basis. However, accurate loads prediction in rotating frame components remains a challenge. Even with advanced computational fluid dynamics (CFD) techniques, prediction of the unsteady aerodynamic loads acting on the rotor blades is computationally intensive and problematic in terms of accurate loads prediction across the entire flight regime of the helicopter. High-speed flight can potentially introduce both shock and near-stall effects within a given rotor rotation. Low-speed flight can include blade-vortex interaction effects, wherein flow from a given blade (vorticity loading from tip vortices) impinges upon the preceding blade, causing unsteady aerodynamic loading that is difficult to quantity and predict numerically. Vehicle maneuvering can produce significantly higher blade pitching moments than steady flight. All of these regimes combine to represent the loading history of the rotor system. Therefore, accurate loads prediction methods, in terms of matching peak-to-peak, magnitude, phase, as well as vibratory/harmonic content, are required that capture all flight regimes for all critical structural components. This research focuses on the development of a loads prediction method, known as the Load Confluence Algorithm (LCA), and its application to the analysis of a large set of flight test data from the NASA/US Army UH-60A Airloads Program. The LCA combines measured response at a prescribed set of locations with a numerical model of the rotor system. For a given flight condition (steady flight, maneuvers, etc.) the numerical simulation's predicted loads distribution is iteratively incremented (by harmonic) until convergence with measured loads is reached at the prescribed locations (control points). Predicted loads response at non-instrumented locations is shown to be improved as well, thus enhancing fatigue lifing methods for these components. The procedure specifically investigates the harmonic content of the applied loads and the improved prediction of the harmonic components. The impact of the enhanced accuracy on loads predictions on component structural fatigue is illustrated by way of an example. Results show that, for a limited sensor set (two 3-axis sensors per blade), blade loads are accurately predicted across a full range of flight regimes. Hub loads are best modeled using the pushrod as the control point. Results also show that load magnitude has a tremendous influence on damage, with a 25% over-estimation of vibratory load resulting in a damage factor of nearly 3. This research highlights the importance of accurate loads prediction for a rotorcraft life tracking program. Small inaccuracies in loads lead to dramatic errors in damage assessment.

Regeneration of large bone defects presents a critical challenge to orthopaedic clinicians as the current treatment strategies are severely limited. Tissue engineering has therefore emerged as a promising alternative to bone grafting techniques. This approach features the delivery of bioactive agents such as stem cells, genes, or proteins using biomaterial delivery systems which together stimulate endogenous repair mechanisms to regenerate the tissue. Because bone is a highly mechanosensitive tissue which responds and adapts dynamically to its mechanical environment, application of mechanical stimuli may enhance endogenous tissue repair. While mechanical loading has been shown to stimulate bone fracture healing, the ability of loading to enhance large bone defect regeneration has not been evaluated. The goal of this thesis was to evaluate the ability of sustained osteogenic growth factor delivery and functional biomechanical loading to stimulate vascularized repair of large bone defects in a rat segmental defect model. First, we evaluated the hypothesis that the relationship between protein dose and regenerative efficacy depends on delivery system. We determined the dose-response relationship between dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) and bone regeneration in a hybrid alginate-based protein delivery system and compared with the current clinically-used collagen sponge. The hybrid delivery system improved bone formation and reduced the effective dose due to its sustained delivery properties in vivo. Next, we tested the hypothesis that transfer of compressive ambulatory loads during segmental defect repair enhances bone formation and subsequent limb regeneration. We found that delayed application of axial loads enhanced bone regeneration by altering bone formation, tissue differentiation and remodeling, and local strain distribution. Finally, we evaluated the hypothesis that in vivo mechanical loading can enhance neovascular growth to influence bone formation. We found that early mechanical loading disrupted neovascular growth, resulting in impaired bone healing, while delayed loading induced vascular remodeling and enhanced bone formation. Together, this thesis presents the effects of dose and delivery system on BMP-mediated bone regeneration and demonstrates for the first time the effects of in vivo mechanical loading on vascularized regeneration of large bone defects.

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A generalized approximate hand method of analysis is presented for determining the lateral deflections and internal forces in complex multi-storey structures subject to lateral loading. The buildings may include symmetric or asymmetric combinations of coupled walls, rigid frames, shear walls, wall-frames, rigid frames with central walls, frames with single and multi-storey bracing systems as well as cores that are either open or partially closed by floor beams. The deformations taken into account include bending, axial, shear and torsion. / The analysis is based on the continuous medium technique in which the bents in the structure are replaced by idealized assemblies representing their characteristic modes of behaviour. The proposed method is restricted to structures with uniform geometry up the height and linear elastic behaviour of the structural members. / Design equations are presented for the conventional lateral loading cases: a concentrated load at the top of the structure, a uniformly distributed load, and a triangularly distributed load with maximum intensity at the top. The simplicity of this method allows the sway of a structure, the maximum storey sway and its location in the height of the structure to be determined graphically. This procedure enables not only a rapid estimate of the deflections in the structure but together with an assessment of the internal forces it provides a design office method of comparing the efficiencies of different structural alternatives in the preliminary design of tall building structures.

Thesis (M.S.)--Oregon State University, 2009. / Printout. Includes bibliographical references (leaves 133-138). Also available on the World Wide Web.

Thesis (Ph. D.)--University of Texas at Austin, 2008. / Vita. Includes bibliographical references.

Thesis (Ph. D.)--Ohio State University, 2008. / Title from first page of PDF file. Includes bibliographical references (p. 172-177).