Spelling suggestions: "subject:"lung surfactant (LS) monolayer"" "subject:"tung surfactant (LS) monolayer""
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The role of SP-B1-25 peptides in lung surfactant monolayers exposed to gold nanoparticlesHossain, S.I., Gandhi, N.S., Hughes, Zak E., Saha, S.C. 29 June 2020 (has links)
Yes / Lung surfactant (LS) monolayers that continuously expand and compress during breathing cycles, act as
the first line barrier for inhaled nanoparticles. It is known that nanoparticles which adsorb to the surface
of the surfactant layer facilitate the rearrangement of lipids and peptides at various stages of the
breathing cycle. However, the structural mechanisms for this ability of the lipid rearrangement are not
yet fully understood. Coarse-grained molecular dynamics simulations are performed to investigate
the role of surfactant protein B (SP-B) segments (SP-B1–25) in modulating the biophysical properties
of the surfactant monolayer in the presence of polydisperse gold nanoparticles (AuNPs) at different
concentrations. Herein, we observe that the AuNPs significantly alter the inherent structural and
dynamical properties of the monolayer and its components in three different breathing states. When
adsorbed into the monolayer, the AuNPs inhibit the ability of the monolayer to recover its surface
tension and other properties. The presence of SP-B1–25 in the monolayer accelerates the diffusion of the
monolayer phospholipids, contrarily to the role of AuNPs on phospholipid diffusion. Also, the AuNPs and
the peptides in the monolayer significantly increase their agglomeration in the presence of one another.
Overall, the simulations predict that the presence of polydisperse AuNPs hampers the stability and
biophysical functions of the LS in contrast to the role of the peptide. This study provides a clear view of
the hydrophobic peptide role in the LS monolayer at the interface along with the interactions and the
translocation of AuNPs that could have a significant impact to assess the NPs inhalation. / This work was completed with the support of University of Technology Sydney (UTS) FEIT Research Scholarship, UTS IRS (S. I. H.).
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