The present research study is comprised of two main parts. The first part aims at the development of a systematic system-theoretic framework that allows the derivation of optimal chemotherapy protocols for HIV patients. The proposed framework is conceptually aligned with a notion of continuous-time model predictive control of nonlinear dynamical systems, and results in an optimal way to control viral replication, while maintaining low antiretroviral drug toxicity levels. This study is particularly important because it naturally integrates powerful system-theoretic techniques into a clinically challenging problem with worldwide implications, namely the one of developing chemotherapy patterns for HIV patients that are effective and do not induce adverse side-effects. The second part introduces a new digital controller design methodology for nonlinear (bio)chemical processes, that reflects contemporary necessities in the practical implementation of advanced process control strategies via digital computer-based algorithms. The proposed methodology relies on the derivation of an accurate sampled-data representation of the process, and the subsequent formulation and solution to a nonlinear digital controller synthesis problem. In particular, for the latter two distinct approaches are followed that are both based on the methodological principles of Lyapunov design and rely on a short-horizon model-based prediction and optimization of the rate of“energy dissipation" of the system, as it is realized through the time derivative of an appropriately selected Lyapunov function. First, the Lyapunov function is computed by solving the discrete Lyapunov matrix equation. In the second approach however, it is computed by solving a Zubov-like functional equation based on the system's drift vector field. Finally, two examples of a chemical and a biological reactor that both exhibit nonlinear behavior illustrate the main features of the proposed digital controller design method.

Cette thèse est consacrée au développement de techniques de commande avancées pour des classes de systèmes non linéaires en général et pour des applications automobiles en particulier.Pour répondre au besoin du contrôle moteur, la première partie propose des nouveaux résultats théoriques sur la technique de commande non linéaire à base de modèles de type Takagi-Sugeno soumis à la saturation de la commande. La saturation de la commande est traitée en utilisant sa représentation polytopique ou une stratégie anti-windup.La deuxième partie porte sur la commande du système d'air d'un moteur turbocompressé à allumage commandé. Deux approches originales sont proposées. Dans la première, l'outil théorique concernant les modèles Takagi-Sugeno à commutation développé dans la première partie est directement appliqué. La seconde approche est basée sur une commande linéarisante robuste. L'originalité de ces approches multivariables consiste dans sa simplicité de mise en œuvre et son efficacité par rapport à celles qui existent dans la littérature.La dernière partie vise à développer des stratégies pour la gestion énergétique des systèmes électriques d'un véhicule obtenues en se basant sur le Principe du Minimum de Pontryagin. À cet effet, deux approches sont considérées : l'approche hors ligne d'optimisation utilisant les informations du futur concernant les conditions de roulage et l'approche en ligne qui est adaptée de la précédente. Ensuite, ces deux approches sont implémentées et évaluées dans un simulateur avancé. / This thesis addresses the development of some advanced control design tools for a class of nonlinear systems in general and for automotive systems in particular.Motivated by automotive applications, Part I proposes some novel theoretical results on control design for nonlinear systems under Takagi-Sugeno form subject to the control input saturation. The input saturation is dealt with by using its polytopic representation or an anti-windup strategy.Part II deals with our automotive application concerning the control of a turbocharged air system of a spark ignition engine. To this end, two novel control approaches are proposed in this part. For the first one, the theoretical design tool on switching Takagi-Sugeno controller developed in Part I is directly applied. The second one is based on a robust feedback linearization control technique. The originality of these MIMO approaches consist in their simplicity and effectiveness compared to other ones existing in the literature.Part III aims at developing the strategies, which are based on the Pontryagin's Minimum Principle in optimal control theory, for the energy management of the vehicular electric power systems in a hybrid engine configuration. To this end, both offline optimization approach using the future information of driving conditions and online implementable one have been developed and evaluated in an advanced simulator.