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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Desenvolvimento de membranas de poliuretano com rapamicina e seu potencial uso em regenera??o vascular

Cabral, Emanuelli Louren?o 19 April 2016 (has links)
Submitted by Salete Sartori (ssartori@pucrs.br) on 2017-01-16T13:46:11Z No. of bitstreams: 1 DIS_EMANUELLI_LOURENCO_CABRAL_COMPLETO.pdf: 2324920 bytes, checksum: cdf79816569d7d9b352a5a2d9b93437f (MD5) / Made available in DSpace on 2017-01-16T13:46:11Z (GMT). No. of bitstreams: 1 DIS_EMANUELLI_LOURENCO_CABRAL_COMPLETO.pdf: 2324920 bytes, checksum: cdf79816569d7d9b352a5a2d9b93437f (MD5) Previous issue date: 2016-04-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / The use of biomaterials that can replace or restore damaged tissues in the human body is necessary to improve the quality and life expectancy of the population. In this sense, the present project aims the study and development of different membranes based on biostable polyurethane, the incorporation of rapamycin, an antithrombogenic drug that can help about the inhibition of blood vessel narrowing, and the evaluation to verify its potential application in vascular area. Therefore, the obtained membranes showed three different morphologies, a membrane with porous surface (average pore size 3,3 ?m ? 0,8 ?m) ? named porous PU ? other membrane with an irregular surface, but without porous ? dense PU ? and for the last, a membrane with internal interconnections ? leached PU. There were realized for each membrane the tests of wettability and contact angle. The leached PU showed higher average of body fluid absorption and porous PU showed higher hydrophilicity, however after the addition of rapamycin, dense PU showed more hydrophilicity. About calcification test, both of three membranes showed minerals deposition, but this did not happen with dense PU after incorporation of drug. The thermal characterizations of the membranes were according with literature for polyurethanes, as the mechanical behavior. Lastly, the membranes did not showed in vitro cytotoxicity, which means that they could be used within our bodies. Thus, the obtained membranes showed their interesting and high potential for use and improvement / O uso de biopol?meros que possam substituir ou restaurar tecidos danificados no corpo humano ? necess?rio para a melhoria na qualidade e expectativa de vida da popula??o. Neste sentido, o presente projeto visa o estudo e desenvolvimento de diferentes membranas baseadas em poliuretano bioest?vel, a incorpora??o da rapamicina, um f?rmaco antitrombog?nico que pode auxiliar na inibi??o do estreitamento dos vasos sangu?neos, e a avalia??o para verificar sua potencial aplica??o na ?rea vascular. Sendo assim, as membranas obtidas apresentaram tr?s morfologias distintas, uma membrana com superf?cie totalmente porosa (tamanho m?dio de poros de 3,3 ?m ? 0,8 ?m) ? denominada PU poroso ? outra com irregularidades em sua superf?cie, por?m sem poros ? PU denso ? e por fim, uma membrana com interconex?es internas ? PU lixiviado. Para cada membrana foram realizados ensaios como teste de inchamento e an?lise do ?ngulo de contato. O PU lixiviado apresentou maior m?dia de absor??o de fluido corp?reo e o PU poroso apresentou maior hidrofilicidade, contudo, ap?s a adi??o da rapamicina o PU denso mostrou-se mais hidrof?lico. Em rela??o ao teste de calcifica??o, as tr?s membranas apresentaram dep?sito de minerais, o que n?o ocorreu para o PU denso ap?s a adi??o do f?rmaco. As caracteriza??es t?rmicas das membranas mostraram-se de acordo com a literatura para poliuretanos, assim como o comportamento mec?nico. Por fim, os estudos de citotoxicidade mostraram que as membranas n?o s?o citot?xicas, podendo ser utilizadas dentro do nosso organismo. Dessa maneira, as membranas obtidas mostram-se interessantes e com grande potencial de uso e aperfei?oamento

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