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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Jugular venous reflux and white matter abnormalities in Alzheimer's disease: a pilot studyChung, C.P., Beggs, Clive B., Wang, P.N., Bergsland, N., Shepherd, Simon J., Cheng, C.Y., Ramasamy, D.P., Dwyer, Michael G., Hu, H.H., Zivadinov, R. January 2014 (has links)
yes / To determine whether jugular venous reflux (JVR) is associated with cerebral white matter changes (WMCs) in individuals with Alzheimer's disease (AD), we studied 12 AD patients 24 mild cognitive impairment (MCI) patients, and 17 elderly age- and gender-matched controls. Duplex ultrasonography and 1.5T MRI scanning was applied to quantify cerebral WMCs [T2 white matter (WM) lesion and dirty-appearing-white-matter (DAWM)]. Subjects with severe JVR had more frequently hypertension (p = 0.044), more severe WMC, including increased total (p = 0.047) and periventricular DAWM volumes (p = 0.008), and a trend for increased cerebrospinal fluid volumes (p = 0.067) compared with the other groups. A significantly decreased (65.8%) periventricular DAWM volume (p = 0.01) in the JVR-positive AD individuals compared with their JVR-negative counterparts was detected. There was a trend for increased periventricular and subcortical T2 WMC lesion volumes in the JVR-positive AD individuals compared with their JVR-negative counterparts (p = 0.073). This phenomenon was not observed in either the control or MCI groups. In multiple regression analysis, the increased periventricular WMC lesion volume and decreased DAWM volume resulted in 85.7% sensitivity and 80% specificity for distinguishing between JVR-positive and JVR-negative AD patients. These JVR-WMC association patterns were not seen in the control and MCI groups. Therefore, this pilot study suggests that there may be an association between JVR and WMCs in AD patients, implying that cerebral venous outflow impairment might play a role in the dynamics of WMCs formation in AD patients, particularly in the periventricular regions. Further longitudinal studies are needed to confirm and validate our findings.
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"Transtorno de identidade sexual: um estudo psicopatológico de transexualismo masculino e feminino" / Sexual identity disorder : a psychopathological disorder of male and female transsexualismSaadeh, Alexandre 27 September 2004 (has links)
Esse estudo propôs-se avaliar presença de transtornos de eixo I, personalidade e caracterizar demograficamente 33 transexuais (masculinos e femininos). Outros objetivos foram comparar Depressão e Transtornos de Personalidade após dois anos de psicoterapia grupal e estruturar um temário específico para ela. Foram aplicados: SCID-I/P, Beck, Hamilton e Entrevista Estruturada para Distúrbios da Personalidade pelo DSM-III-R. As características demográficas gerais não variaram nos grupos. Não houve nenhum diagnóstico psiquiátrico prevalente. Houve predomínio de sintomas depressivos e não de quadros clínicos de depressão. Quanto aos transtornos e traços de personalidade, nenhum dado estatisticamente significativo foi encontrado. Temas para psicoterapia foram estabelecidos. / This study aimed to evaluate the presence of personality disorders of axis I as well as to characterize demographically 33 transsexuals (male and female). Other objectives were to compare depression and personality disorders after two years of group therapy and structure a specific theme list to it. SCID-I/P, Beck, Hamilton and Structured Interview for Personality disorders by the DMS-III-R were applied. General demographic characteristics did not vary among the groups. There was no prevailing psychiatric diagnosis. As for disorders and personality traits, no statistically significant data was found. Psychotherapy themes were established.
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"Transtorno de identidade sexual: um estudo psicopatológico de transexualismo masculino e feminino" / Sexual identity disorder : a psychopathological disorder of male and female transsexualismAlexandre Saadeh 27 September 2004 (has links)
Esse estudo propôs-se avaliar presença de transtornos de eixo I, personalidade e caracterizar demograficamente 33 transexuais (masculinos e femininos). Outros objetivos foram comparar Depressão e Transtornos de Personalidade após dois anos de psicoterapia grupal e estruturar um temário específico para ela. Foram aplicados: SCID-I/P, Beck, Hamilton e Entrevista Estruturada para Distúrbios da Personalidade pelo DSM-III-R. As características demográficas gerais não variaram nos grupos. Não houve nenhum diagnóstico psiquiátrico prevalente. Houve predomínio de sintomas depressivos e não de quadros clínicos de depressão. Quanto aos transtornos e traços de personalidade, nenhum dado estatisticamente significativo foi encontrado. Temas para psicoterapia foram estabelecidos. / This study aimed to evaluate the presence of personality disorders of axis I as well as to characterize demographically 33 transsexuals (male and female). Other objectives were to compare depression and personality disorders after two years of group therapy and structure a specific theme list to it. SCID-I/P, Beck, Hamilton and Structured Interview for Personality disorders by the DMS-III-R were applied. General demographic characteristics did not vary among the groups. There was no prevailing psychiatric diagnosis. As for disorders and personality traits, no statistically significant data was found. Psychotherapy themes were established.
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