International Telemetering Conference Proceedings / October 18-21, 2004 / Town & Country Resort, San Diego, California / A flexible system has been designed to accurately measure and average the outgoing laser energy of a micro-pulse LIDAR unit (MPL). This system incorporates specifically designed analog measurement circuitry interfaced with a microcontroller, allowing researchers to manage experiments from a personal computer. The final system produces a linearly proportional response between an incident laser energy input and the analog and digital circuitry’s output, accurate to within 0.1%. Custom designed algorithms allow the system to average the energy measured in a series of pulses. Each series can range on the order of tens of thousands of pulses.

Les néoplasmes myéloprolifératifs (NMPs) classiques BCR-ABL négatifs regroupent la Polyglobulie de Vaquez, la Thrombocytémie Essentielle et la Myélofibrose Primaire. Ce sont des pathologies malignes clonales entraînées par la signalisation constitutive de la voie JAK2/STAT en raison de mutations somatiques acquises qui affectent trois gènes, JAK2, CALR et MPL. Il s’agit des mutations “motrices” de la maladie responsable du syndrome myéloprolifératif et du phénotype. Cependant CALR n’est pas une molécule de signalisation mais une chaperonne du réticulum endoplasmique. En utilisant des lignées dépendantes de facteurs de croissance soit murines (Ba/F3) soit humaines (UT-7), des cellules primaires de patients et des modèles murins nous avons montré que les mutants CALRdel52 et CALRins5 avaient acquis de nouvelles propriétés qui en font des molécules de signalisation en induisant: - une indépendance aux facteurs de croissance uniquement lorsque MPL, le récepteur de la thrombopoïétine est exprimé ; - une phosphorylation constitutive de JAK2, des STAT1, 3 et 5 et une activation faible des voies PI3K/AKT et ERK1/2, suggérant une activation de MPL/JAK2 par les mutants CALR différente de celle induite par JAK2V617F. De manière intéressante un mutant de la CALR ayant une délétion entière de l’exon 9 n’est pas transformant, suggérant que l’activité oncogénique est liée à la présence de la nouvelle séquence C-terminale. L’activation de JAK2 uniquement par MPL en présence des mutants CALR pourrait expliquer le phénotype mégacaryocytaire/plaquettaire de ces NMPs. Cette activation de MPL au contraire de celle exercée par JAK2V617F a lieu non seulement à la membrane mais aussi dans le cytoplasme.Les modèles murins ont montré que les mutants CALR étaient responsables de la maladie et que celle-ci était dépendante de MPL, validant les résultats obtenus sur les lignées.Nous avons également montré que contrairement à JAK2V617F, les mutants de la CALR induisent chez l’homme une dominance clonale très tôt au niveau du compartiment des cellules souches. L’ensemble de ces résultats contribue à une meilleure compréhension du rôle des mutations CALR dans les NMPs. La démonstration que les molécules mutées sont présentes à la surface cellulaire ouvre la voie à des immunothérapies ciblant le nouveau peptide C-terminal. / Classical BCR-ABL negative myeloproliferative neoplasms (MPNs) include three disorders: Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis. They are clonal malignant diseases driven by the constitutive JAK2/STAT signaling pathway due to acquired somatic mutations affecting three genes: JAK2, CALR and MPL. These are the "driver" mutations of the disease responsible of the myeloproliferation and of the disease phenotype. However, CALR is not a signaling molecule, but a chaperonne of the endoplasmic reticulum. Using murine (Ba/F3) and human (UT-7) cell lines dependent on growth factors and primary patient cells and mouse model, we have shown that the CALRdel52 and CALRins5 mutants have acquired new signaling properties and induce:- growth factor independence only when MPL, the thrombopoietin receptor, is expressed;- constitutive phosphorylation of JAK2, of STAT1, 3 and 5 and a low activation of the PI3K/AKT and ERK1/2 pathways, suggesting an activation of MPL/JAK2 by a different manner than JAK2V617F. Interestingly, a CALR mutant deleted for the entire exon 9 has not transformation properties suggesting that the oncogenic activity is related to the presence of the new C-terminal sequence. This JAK2 activation only by MPL in presence of CALR mutants could explain the megakaryocytic/platelet phenotype of these MPNs.The use of a mouse modeling using retroviral vectors and bone marrow transplantation has shown that CALRdel52 and ins5 were really the drivers of the disease and that in vivo the thrombocytosis was dependent of MPL validating the results obtained in vitro.In addition, we have shown that in human, CALR mutants induce a clonal dominance early in the stem cell compartment in ET. This is in sharp contrast with JAK2V617F in ET. Overall, these results contribute to a better comprehension of the role of CALR mutations in MPNs. Furthermore, the demonstration that the CALR mutants are expressed at the cell surface open the way to the development of new immunotherapy targetting the new C-terminus peptide.

No description available.

There are available various professional applications for the solving of optimization problems. This thesis deals with comparison of these optimization systems and simplicity of their connection with MS Excel through VBA. Problem of designing model together with his calculation in MS Excel or other systems connected via VBA, like MPL for Windows or LINGO, is demonstrated on concrete examples. Application in Visual Basic for Applications was created for this purpose. This application is easy to use and it is solving Knapsack Problem, Distribution Problem and also Quadratic Assignment Problem. Finally, comparison of these systems is made using Multi-criteria evaluation.

This master´s thesis provides an overview of diferences between conventional way to obtain ATPL licence and MPL course. Next focus is on the flight schools providing this courses and air carriers requirements to their future pilots.

Submitted by Jamile Barbosa da Cruz (jamile.cruz@ucsal.br) on 2016-10-06T17:59:46Z No. of bitstreams: 1 dossie final final (1).pdf: 550623 bytes, checksum: dbf08d6b67779615ce85d879b79df2f3 (MD5) / Approved for entry into archive by Maria Emília Carvalho Ribeiro (maria.ribeiro@ucsal.br) on 2016-11-25T21:14:03Z (GMT) No. of bitstreams: 1 dossie final final (1).pdf: 550623 bytes, checksum: dbf08d6b67779615ce85d879b79df2f3 (MD5) / Made available in DSpace on 2016-11-25T21:14:03Z (GMT). No. of bitstreams: 1 dossie final final (1).pdf: 550623 bytes, checksum: dbf08d6b67779615ce85d879b79df2f3 (MD5) Previous issue date: 2015-12-17 / Essa pesquisa analisa o papel das redes sociais da Internet diante dos movimentos sociais no Brasil. Leva em conta as manifestações que utilizaram esse instrumento, ocorridas em 2013, essa dissertação visa observar como se deu o processo de transformação da comunicação e a inclusão desse novo meio de comunicação à sociedade, assim como, qual sua instrumentalidade, ou seja, de que forma esse meio atua e se dissemina. Para isso, vai ser feito aqui um estudo de caso sobre o movimento do passe livre (MPL), já que este foi ponto de partida para desencadear as manifestações mais atuais, nessa pesquisa vai ser aplicado um questionário semi estruturado a militantes e atores sociais desse movimento, com recorte espacial em Salvador.A globalização foi um processo que trouxe mudanças significativas à sociedade, não apenas ligada a uma reforma estrutural das tecnologias de informação, mas também, quanto as relações sociais que deixaram de ser face a face, como nos primórdios e passaram a ser mediadas pelos meios de comunicação. Dentre esses meios a Internet se destaca por ser um que consegue ter um alcance da massa de forma rápida e interativa e por ser um meio de transformação das relações sociais. A Internet, diferente do que se pensava veio para agregar os meios de comunicação já existentes e não para substituí-los, hoje ela é utilizada como espaço de debate público onde estão em pauta os mais diversos temas de interesse social. Foi com esse caráter social que as redes sociais se tornaram lugar para debate e organização das manifestações ocorridas no Brasil desde 2013. As manifestações ocorridas a partir do Movimento do Passe Livre, começaram a ser organizadas nos fóruns de debate na rede e na conhecida rede social, o Facebook¸ com isso centenas de pessoas passaram a ir as ruas reivindicar por pautas como, saúde, educação e reformas políticas. Essa dissertação trás no seu conteúdo quais foram as motivações desses manifestos, até que ponto as redes sociais organizam essas ações e como a sociedade lida como esse processo. E trás uma observação final de que as novas redes mobilizam e organizam o movimento assim como transforma a forma de comunicação da sociedade. / This research will examine the role of social networks on the Internet of social movements in Brazil. Taking into account the events that used this instrument, which began in 2011, this dissertation aims to observe how was the process of transformationof communication andtheinclusionofthis new mediumtosociety, as well as whattheirinstrumentality, iethatsothismeans it operatesand spreads. For this, will be done here is a case study of the movement of the free pass (MPL), as this was the starting point to trigger the most current manifestations, this research will be applied a semi structured questionnaire to members and stakeholders that movement with spatial area in Salvador. Globalization was a process that brought significant changes to society, not only linked to a structural reform of information technology, but also as the social relations that no longer face to face, as in the early days and became mediated by means of communication. Among these means the Internet stands out as one that can have a range of mass quickly and interactively and be a means of transforming social relations. The Internet, unlike previously thought came to add the media already and not to replace them, today it is used as a space for public debate where they are on the agenda the most diverse topics of social interest. It was with this social character that social networks have become place for debate and organization of the demonstrations that took place in Brazil since 2011. The demonstrations occurred from the Free Pass Movement, began to be organized in discussion forums on the network and known social network , Facebook with it hundredsof people began to go claim the streets as guidelines, health, education and political reform. This dissertation back in its content the motivations of these manifestos, the extent to which social networks organize these actions and how society deals as this process. And behind a final observation that the new networks mobilize and organize the movement as well as changes the way of communication of society.

Psicóloga / En la presente investigación, desde la Psicología Social Crítica intentamos comprender los significados que las pobladoras dirigentas del Proyecto Habitacional „Comunidad Las Araucarias‟ del Movimiento de Pobladores en Lucha construyen en torno a su participación sociopolítica, entendiendo por ésta al accionar colectivo que tiene implicancias políticas, subjetivas e intersubjetivas. En este marco, utilizando la entrevista en profundidad y el análisis cualitativo, indagamos en las experiencias de participación sociopolítica más significativas para estas mujeres, en la subjetividad que desde aquí emerge y el proyecto político social que en ello van construyendo. Dentro de los principales resultados, la „lucha‟ es la principal fuente de sentidos subjetivos e intersubjetivos, pretendiendo en el espacio público desprenderse de lo impuesto y recuperar todo aquello que se las ha negado. Esto sea presionando y exigiendo al Estado y sus instituciones, así como creando cotidianamente nuevas relaciones y prácticas, basadas en la solidaridad, autogestión y educación popular

In this dissertation, we present two major lines of numerical investigation based on a control-volume approach to solve coupled, nonlinear differential equations. The first model is developed to provide better understanding of the water management in PEMFC operating at less than 100ºC, under transient conditions. The model provides explanations for the observed differences between hydration and dehydration time constants during load change. When there is liquid water at the cathode catalyst layer, the time constant of the water content in the membrane is closely tied to that of liquid water saturation in the cathode catalyst layer, as the vapor is already saturated. The water content in the membrane will not reach steady state as long as the liquid water flow in the cathode catalyst layer is not at steady state. The second model is to optimize the morphological properties of HT-PEMFCs components so as to keep water generated as close as possible to the membrane to help reduce ionic resistance and thereby increase cell performance. Humidification of the feed gas at room temperature is shown to have minimal effects on the ionic resistance of the membrane used in the HT-PEMFC. Feed gases must be humidified at higher temperature to have effects on the ionic resistance. However, humidification at such higher temperatures will require complex system design and additional power consumption. It is, therefore, important to keep the water generated by the electrochemical reaction as close as possible to the membrane to hydration the membrane so as to reduce the ionic resistance and thereby increase cell performance. The use of cathode MPL helps keep the water generated close to the membrane and decreasing the MPL porosity and pore size will increase the effectiveness of the MPL in keep the water generated close to the membrane. The optimum value of the MPL porosity depends on the operating conditions of the cell. Similarly, decreasing the GDL porosity helps keep water close to the membrane and the optimum value of the GDL porosity depends on the operating conditions of the cell. / text

No description available.

The question of how to measure and classify people's risk preferences is of substantial importance in the field of economics. Inspired by the multitude of ways used to elicit risk preferences, we conduct a holistic investigation of the most prevalent method, the multiple price list (MPL) and its derivations. In our experiment, we find that revealed preferences differ under various versions of MPLs as well as yield unstable results within a 30-minute time frame. We determine the most stable elicitation method with the highest forecast accuracy by using multiple measures of within-method consistency and by using behavior in two economically relevant games as benchmarks. A derivation of the well-known method by Holt and Laury (American Economic Review 92(5):1644-1655, 2002), where the highest payoff is varied instead of probabilities, emerges as the best MPL method in both dimensions. As we pinpoint each MPL characteristic's effect on the revealed preference and its consistency, our results have implications for preference elicitation procedures in general.