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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
81

European Black Grouse : MHC Genetic Diversity and Population Structure

Strand, Tanja January 2011 (has links)
Black grouse Tetrao tetrix is a bird species composed of large, continuous as well as severely reduced and fragmented populations, making it an optimal species to investigate how genetic diversity is affected by habitat fragmentation. I have focused on genetic diversity in the Major Histocompatibility Complex (MHC) to measure the ability of the black grouse to respond to environmental changes. I partly characterized MHC class II in black grouse and found striking similarities with chicken MHC class II. I demonstrated that black grouse possess a similar compact MHC as chicken with few MHC class II B (BLB) and Y (YLB) loci. I did not find evidence of balancing selection in YLB so I concentrated further studies on BLB. I developed a PCR-based screening method for amplifying and separating expressed BLB alleles in European black grouse populations. Small fragmented populations had lost neutral genetic diversity (based on microsatellites and SNPs) compared to samples from the historical distribution and contemporary large populations. There was also a trend, albeit less pronounced, for reduced MHC diversity in these populations. Neutral markers in small isolated populations were affected by increased levels of genetic drift and were therefore genetically differentiated compared to other populations. MHC markers on the other hand, were not subjected to genetic drift to the same extent probably due a long historic process of balancing selection. Inferences of heterozygosity and evolutionary patterns as well as detailed correlations to reproductive success and diseases cannot be performed until MHC can be amplified in a locus-specific manner. Therefore, I developed a single locus sequence-based typing method for independently amplifying MHC class II B loci (BLB1 and BLB2). I found that BLB1 and BLB2 were duplicated in a common ancestor to chickens and black grouse and that these loci are subjected to homogenizing concerted evolution due to inter-genetic exchange between loci after species divergence.  I could also verify that both BLB1 and BLB2 were transcribed in black grouse and under balancing selection. This collection of work has significance for future conservation of black grouse as well as research and management of zoonotic diseases.
82

Genetics and inflammation in nerve injury-induced neurodegeneration /

Lidman, Olle, January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol inst., 2003. / Härtill 7 uppsatser.
83

Inhibition of apoptosis by the Us3 protein kinase of herpes simplex virus 1 /

Cartier, Anna, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 3 uppsatser.
84

Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes /

Hallermalm, Kristian, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
85

Genetic variations influencing susceptibility to multiple sclerosis /

Duvefelt, Kristina, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.
86

Exosomes in immune regulation and allergy /

Admyre, Charlotte, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
87

Peptide binding, TCR recognition and intrathymic positive selection : by an MHC H-2Kb class I molecule devoid of the central anchor ("c") pocket /

Molano, Alberto. January 1998 (has links)
Thesis (Ph. D.)--Cornell University, January, 1998. / Vita. Includes bibliographical references (leaves 95-111).
88

Novel MHC analyses allow prediction of extreme genetic risk for type 1A diabetes /

Aly, Theresa Ann. January 2007 (has links)
Thesis (Ph.D. in Human Medical Genetics) -- University of Colorado Denver, 2007. / Typescript. Includes bibliographical references (leaves 94-108). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
89

Epitope immunodominance and the murine cytotoxic T lymphocyte response to Listeria monocytogenes /

Wipke, Brian Todd, January 1997 (has links)
Thesis (Ph. D.)--University of Washington, 1997. / Vita. Includes bibliographical references (leaves [93]-113).
90

Interactions of MHC class I molecules with peptide ligands and [beta]₂-microglobulin

Robinson-Smith, Ruth A. January 1996 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 1996. / Typescript. Vita. Includes bibliographical references (leaves : [128]-155). Also available on the Internet.

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