<p>Uvod: Kraniofacijalni sistem je svim svojim strukturama razvojno, funkcionalno i anatomski tesno vezan sa strukturama gornjih respiratornih puteva. Tako je svaki poremećaj u jednom od njih često praćen manjim ili većim poremećajem u drugom. Ovaj rad se bavi utvrđivanjem mogućnosti da se prepoznaju neki od orofacijalnih faktora kod dece koji bi mogli da uzrokuju ili povećaju ozbiljnost smetnji u disanju. Od posebnog je značaja činjenica da se većina autora bavi tretiranjem odrasle populacije, dok samo nastajanje poremećaja nije jasno obja&scaron;njeno. Zbog toga je ovaj rad zami&scaron;ljen kao doprinos saznanju o nekim od mnogih međusobno veoma kompleksno isprepletanih funkcionalnih i morfolo&scaron;kih poremećaja koji svi zajedno dovode do ovog potencijalno opasnog, a globalno prisutnog stanja. U ovom istraživanju posebna pažnja se obraća na uticaj poremećenih međuviličnih odnosa u sagitalnoj dimenziji (posteriorni odnos struktura donje vilice) kod dece koja nisu zavr&scaron;ila rast i kod koje se jo&scaron; uvek može terapijski delovati, kao i na sagitalnu uskost gornjih respiratornih puteva. Skeletno II klasa je poremećaj kraniofacijalnog razvoja koji se u dece leči, dok je kod odraslih sa zavr&scaron;enim rastom taj odnos vilica fiksiran. Ispravljanje morfolo&scaron;ke nepravilnosti kod dece koriguje se pravilnim usmeravanjem rasta, i normalizacijom poremećenih funkcija orofacijalne i nathioidne muskulature, &scaron;to se postiže primenom funkcionalnih ortodontskih aparata. Ciljevi i hipoteze: Op&scaron;ti cilj rada je da se doprinese saznanjima o dimenzijama struktura u periodu razvoja koje mogu u kasnijim životnim dobima da doprinesu nastanku smetnji u disanju i nekom od &scaron;irokog spektra poremećaja opisanih kao sindrom opstruktivnog prekida disanja u toku sna, kao i da se sagledaju mogućnosti ranog delovanja na njih. Metode: Ispitivanje je sprovedeno kao kombinacija studije preseka u svom prvom delu I kohortne studije u svom drugom delu, na Klinici za stomatologiju Vojvodine. Studijom je obuhvaćeno 98 ispitanika eksperimentalne grupe koji su ispunjavali kriterijume za uključivanje u studiju, odgovarajućeg uzrasta i kraniofacijalne morfologije (druga skeletna klasa i hiperdivergentan rast), kao i 70 (dve grupe po 35) ispitanika kontrolne grupe odgovarajućeg uzrasta kao reprezent op&scaron;te populacije. Kod svih ispitanika izvr&scaron;ena su standardna rendgenkefalometrijska merenja i utvrđene dimenzije gornjih respiratornih puteva, kao i struktura koje bi mogle da imaju uticaja na njih, jezika i mekog nepca. Dobijene vrednosti su upoređene statistički. Posle godinu dana ortodontskog lečenja malokluzije druge klase, pristupilo se ponovnom merenju istih struktura, upoređivanju sa kontrolnom grupom odgovarajućeg uzrasta, kao i utvrđivanju nastalih promena u odnosu na početni nalaz. Da bi se utvrdio stvarni opseg promena nastalih usled ortodontske terapije, upoređen je stepen promene i kod kontrolne grupe na početku i kraju opservacionog perioda. Rezultati: Utvrđene su sagitalne dimenzije gornjih respiratornih puteva kod ispitanika sa hiperdivergentnom malokluzijom klase II/1. Utvrđene dimenzije su značajno manje kod ispitanika sa klasom II/1 nego kod op&scaron;te populacije, na sva tri posmatrana nivoa, nivou nazofarinksa, nivou orofarinksa i nivou hipofarinksa. Ne postoji statistički značajna međuzavisnost između sagitalnih dimenzija gornjih respiratornih puteva i skeletnih odnosa u sagitalnoj dimenziji. Nakon ortodontskog lečenja funkcionalnim aparatima, kod ispitanika su se dimenzije gornjih disajnih puteva na sva tri posmatrana nivoa povećale. Zaključak: Nalazi potvrđuju da su gornji disajni putevi kod osoba sa hiperdivergentnom klasom II/1 uži nego kod ostatka populacije, kao i da uravnotežavanje njihovih morfofunkcionalnih odlika u toku rasta ortodontskim lečenjem dovodi i do skladnijeg razvoja faringealnih struktura koje izgrađuju gornje disajne puteve.</p> / <p>Introduction: Craniofacial system has all of its structures developmentally, functionally and anatomically closely related to the structures of the upper respiratory tract. Thus, any disturbance<br />in any of them is often accompanied by a disorder in the other. This paper is identifying opportunities to recognize some of the orofacial factors in children that could cause or increase the severity of breathing difficulties. Of particular importance is the fact that most authors deal with treating the adult population, while the mere emergence of the developmental disorder is not clearly explained. Therefore, this paper is conceived as a contribution to the knowledge of some of the many mutually very complex, interwoven functional and morphological disorders that together lead to this potentially dangerous, a globally present situation. In this study, special<br />attention is paid to the influence of irregular intermaxillary relationship in the sagittal dimension (posterior position of lower jaw) in children who have not yet completed growth and in which there still can be a therapeutic act, as well as the sagittal narrowness of the upper respiratory tract. Correcting morphological irregularities in children is acheived by modifying and directing the growth and normalization of disturbed functions of orofacial musculature, by the application of functional orthodontic appliances. Objectives and hypotheses: The overall objective of this paper is to contribute to the knowledge of the structures and dimensions of the structures during the period of development, which may in later stages of life contribute to the occurrence of disturbances in breathing and a wide spectrum of disorders described as obstructive sleep apnoea syndrome, as well as to examine the possibility of affecting them early. Methods: The study was conducted as a combination of cross-sectional study in the first part and cohort study in its second part. It was performed at the Clinic of Dentistry of Vojvodina. The study included 98 experimental group subjects who met the criteria for inclusion in the study, appropriate age and craniofacial morphology (second class and hyperdivergent skeletal growth), and 70 (two groups of 35) of controls, being of corresponding ages. Roentgenocephalometric features and the dimensions of the upper respiratory tract were assessed in all subjects, as well as structures that could influence them, tongue and soft palate. The values obtained were compared statistically. After a year of orthodontic treatment of class II malocclusion, re- measurement of the same structures was performed, as well as the comparison with a control group of corresponding age. Changes in relation to the initial findings were tracked. To determine the actual extent of the changes caused by orthodontic treatment, the degree of change was compared in the control group at the beginning and end of the observation period. Results: The sagittal dimensions of the upper respiratory tract are significantly smaller in patients with Class II/1 than in the general population in all three observed levels, the level of the nasopharynx, oropharynx, and the level of level of hypopharynx. There was no significant interdependence between the sagittal dimension of the upper respiratory tract and skeletal relationships in the sagittal dimension. After orthodontic treatment by the means of functional appliances, the dimensions of the upper airway in all three observed levels increased. Conclusion: The findings confirm that the upper airway in patients with hyperdivergent class II/1 malocclusion is narrower than in the rest of the population, as well as that balancing their morphofunctional facial features during growth by orthodontic treatment leads to the more harmonious development of the pharyngeal structures that make up the upper airways.</p>

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Pacientes portadores de deformidades dentofaciais podem relatar dificuldades de mastigação e fala, desordens temporomandibulares, preocupação com a imagem corporal e baixa autoestima. Frequentemente, buscam tratamento orto-cirúrgico pela motivação de obter melhora notável nos aspectos estético, funcional e psicossocial. A evidência atualmente disponível sobre os benefícios na qualidade de vida relacionada à saúde bucal desta modalidade terapêutica ainda não é conclusiva, devido à diversidade de metodologias adotadas entre os estudos existentes, majoritariamente realizados na América do Norte, Europa, Oriente Médio e Ásia. Logo, é essencial utilizar instrumentos específicos para avaliar os efeitos desta modalidade de tratamento também na vida diária dos pacientes brasileiros. O propósito do presente estudo transversal foi determinar o impacto que o tratamento orto-cirúrgico exerce sobre a percepção de qualidade de vida dos pacientes portadores de deformidades dentofaciais, bem como a influência exercida pelo gênero, idade, renda, escolaridade e características da má oclusão, nas quatro etapas inerentes a esta modalidade de tratamento: (1) Inicial; (2) Preparo ortodôntico para a cirurgia; (3) Pós-cirúrgico; e (4) Contenção (pós-tratamento). Duzentos e cinquenta e quatro pacientes foram entrevistados em três importantes centros de atendimento na cidade do Rio de Janeiro. A qualidade de vida foi avaliada pelos questionários OHIP-14 (Oral Health Impact Profile - Short Version) e pelo OQLQ (Orthognathic Quality of Life Questionnaire) em suas versões traduzidas e validadas para o português. A gravidade da má oclusão e autopercepção estética foram avaliadas com base no Índice de Necessidade de Tratamento Ortodôntico (IOTN) e pelo Índice de Estética Dental (DAI). A análise dos dados foi efetuada pelos testes qui-quadrado, Kruskal-Wallis e modelos de regressão binomial negativa múltipla. Os pacientes dos quatro grupos foram semelhantes em relação ao gênero (p = 0,463), escolaridade (p = 0,276) e renda familiar (p = 0,100). Entre os entrevistados houve o predomínio de mulheres, com ensino médio completo e renda familiar entre 2 e 3 salários mínimos, portadores de má oclusão de Classe III de Angle grave. No modelo de regressão binomial negativa ajustado para os fatores gênero, idade, renda familiar e escolaridade, a qualidade de vida aferida pelo OHIP-14 demonstrou que o grupo Inicial sofreu impactos mais negativos do que os grupos Pós-cirúrgico, Preparo e Contenção; o OQLQ indicou que o grupo Inicial sofreu impactos mais negativos do que os grupos Preparo, Pós-cirúrgico e Contenção, nesta sequência. Não foi detectada influência da idade, renda e escolaridade nestes resultados. Foi observado que o gênero feminino sofreu mais impacto negativo na qualidade de vida, principalmente nas dimensões relativas à função e a aspectos sociais. Concluiu-se que os pacientes que finalizaram o tratamento orto-cirúrgico apresentaram como benefícios menores impactos na qualidade de vida específica e relacionada à saúde bucal, melhor autopercepção estética e menor gravidade da má oclusão, em comparação aos pacientes nas etapas pré e pós-cirúrgica e aos pacientes portadores de deformidades dentofaciais em busca de tratamento. / Patients with dentofacial deformities may complain about having trouble chewing and speaking, temporomandibular joint disorders, dissatisfaction with their own appearance and low self-esteem. They frequently seek out orthosurgical treatment motivated by an expectation of a significant aesthetic, functional and psychosocial improvement. Evidence currently available is not yet conclusive about the benefits of orthognathic surgery towards Oral Health-Related Quality of Life (OHRQoL). This is due to a lack of consensus among the various methods used to measure the changes among the existing studies, mainly performed in North America, Europe, Middle East and Asia. Therefore the use of specific tools is important to evaluate the effects of this therapeutic modality on the daily life of Brazilian patients. The aim of this cross-sectional study was to assess the impact of orthosurgical treatment on patients perceptions of their OHRQoL, and the influence of gender, age, socioeconomic status, schooling and occlusal characteristics, at the four stages of this treatment modality: (1) Initial; (2) Pre-surgical orthodontic treatment; (3) Post-surgical; and (4) Retention (post-treatment). Two hundred and fifty-four patients were interviewed at three important local attendance centers in the city of Rio de Janeiro. Quality of life was evaluated by OHIP-14 (Oral Health Impact Profile - Short Version) and OQLQ (Orthognathic Quality of Life Questionnaire) translated and validated into Brazilian Portuguese. The severity of Malocclusion and aesthetic self-perception were assessed by IOTN (Index of Orthodontic Treatment Need) and DAI (Dental Aesthetic Index). Data analysis was performed using Chi-square and Kruskal-Wallis tests and negative binomial regression models. The four groups shared similar make up in terms of gender (p = 0.463), schooling (p = 0.276) and economic status (p = 0.100). Among those interviewed, there was a predominance of women, who had graduated from high school, and with family income of between two and three minimum wages, presenting severe Class III malocclusion. In the negative binomial regression model, adjusted for gender, age, family income and schooling, the OHRQoL evaluated by OHIP-14 demonstrated that the Initial group presented more negative impact than the Postsurgical, Pre-surgical or Retention groups; OQLQ showed that the Initial group suffered more negative impacts than the Pre-surgical, Post-surgical and Retention groups, in this sequence. Any influence of age, family income and schooling was not detected. The female gender showed more negative impact on the OHRQoL, primarily concerning dental function and social aspects. It was concluded that patients who completed orthosurgical treatment presented the benefit of less acute impacts on the OHRQoL, better self-perception of the aesthetic and less severe malocclusion, when compared to patients at pre and post-surgical stages and those individuals not treated for dentofacial deformities.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Pacientes portadores de deformidades dentofaciais podem relatar dificuldades de mastigação e fala, desordens temporomandibulares, preocupação com a imagem corporal e baixa autoestima. Frequentemente, buscam tratamento orto-cirúrgico pela motivação de obter melhora notável nos aspectos estético, funcional e psicossocial. A evidência atualmente disponível sobre os benefícios na qualidade de vida relacionada à saúde bucal desta modalidade terapêutica ainda não é conclusiva, devido à diversidade de metodologias adotadas entre os estudos existentes, majoritariamente realizados na América do Norte, Europa, Oriente Médio e Ásia. Logo, é essencial utilizar instrumentos específicos para avaliar os efeitos desta modalidade de tratamento também na vida diária dos pacientes brasileiros. O propósito do presente estudo transversal foi determinar o impacto que o tratamento orto-cirúrgico exerce sobre a percepção de qualidade de vida dos pacientes portadores de deformidades dentofaciais, bem como a influência exercida pelo gênero, idade, renda, escolaridade e características da má oclusão, nas quatro etapas inerentes a esta modalidade de tratamento: (1) Inicial; (2) Preparo ortodôntico para a cirurgia; (3) Pós-cirúrgico; e (4) Contenção (pós-tratamento). Duzentos e cinquenta e quatro pacientes foram entrevistados em três importantes centros de atendimento na cidade do Rio de Janeiro. A qualidade de vida foi avaliada pelos questionários OHIP-14 (Oral Health Impact Profile - Short Version) e pelo OQLQ (Orthognathic Quality of Life Questionnaire) em suas versões traduzidas e validadas para o português. A gravidade da má oclusão e autopercepção estética foram avaliadas com base no Índice de Necessidade de Tratamento Ortodôntico (IOTN) e pelo Índice de Estética Dental (DAI). A análise dos dados foi efetuada pelos testes qui-quadrado, Kruskal-Wallis e modelos de regressão binomial negativa múltipla. Os pacientes dos quatro grupos foram semelhantes em relação ao gênero (p = 0,463), escolaridade (p = 0,276) e renda familiar (p = 0,100). Entre os entrevistados houve o predomínio de mulheres, com ensino médio completo e renda familiar entre 2 e 3 salários mínimos, portadores de má oclusão de Classe III de Angle grave. No modelo de regressão binomial negativa ajustado para os fatores gênero, idade, renda familiar e escolaridade, a qualidade de vida aferida pelo OHIP-14 demonstrou que o grupo Inicial sofreu impactos mais negativos do que os grupos Pós-cirúrgico, Preparo e Contenção; o OQLQ indicou que o grupo Inicial sofreu impactos mais negativos do que os grupos Preparo, Pós-cirúrgico e Contenção, nesta sequência. Não foi detectada influência da idade, renda e escolaridade nestes resultados. Foi observado que o gênero feminino sofreu mais impacto negativo na qualidade de vida, principalmente nas dimensões relativas à função e a aspectos sociais. Concluiu-se que os pacientes que finalizaram o tratamento orto-cirúrgico apresentaram como benefícios menores impactos na qualidade de vida específica e relacionada à saúde bucal, melhor autopercepção estética e menor gravidade da má oclusão, em comparação aos pacientes nas etapas pré e pós-cirúrgica e aos pacientes portadores de deformidades dentofaciais em busca de tratamento. / Patients with dentofacial deformities may complain about having trouble chewing and speaking, temporomandibular joint disorders, dissatisfaction with their own appearance and low self-esteem. They frequently seek out orthosurgical treatment motivated by an expectation of a significant aesthetic, functional and psychosocial improvement. Evidence currently available is not yet conclusive about the benefits of orthognathic surgery towards Oral Health-Related Quality of Life (OHRQoL). This is due to a lack of consensus among the various methods used to measure the changes among the existing studies, mainly performed in North America, Europe, Middle East and Asia. Therefore the use of specific tools is important to evaluate the effects of this therapeutic modality on the daily life of Brazilian patients. The aim of this cross-sectional study was to assess the impact of orthosurgical treatment on patients perceptions of their OHRQoL, and the influence of gender, age, socioeconomic status, schooling and occlusal characteristics, at the four stages of this treatment modality: (1) Initial; (2) Pre-surgical orthodontic treatment; (3) Post-surgical; and (4) Retention (post-treatment). Two hundred and fifty-four patients were interviewed at three important local attendance centers in the city of Rio de Janeiro. Quality of life was evaluated by OHIP-14 (Oral Health Impact Profile - Short Version) and OQLQ (Orthognathic Quality of Life Questionnaire) translated and validated into Brazilian Portuguese. The severity of Malocclusion and aesthetic self-perception were assessed by IOTN (Index of Orthodontic Treatment Need) and DAI (Dental Aesthetic Index). Data analysis was performed using Chi-square and Kruskal-Wallis tests and negative binomial regression models. The four groups shared similar make up in terms of gender (p = 0.463), schooling (p = 0.276) and economic status (p = 0.100). Among those interviewed, there was a predominance of women, who had graduated from high school, and with family income of between two and three minimum wages, presenting severe Class III malocclusion. In the negative binomial regression model, adjusted for gender, age, family income and schooling, the OHRQoL evaluated by OHIP-14 demonstrated that the Initial group presented more negative impact than the Postsurgical, Pre-surgical or Retention groups; OQLQ showed that the Initial group suffered more negative impacts than the Pre-surgical, Post-surgical and Retention groups, in this sequence. Any influence of age, family income and schooling was not detected. The female gender showed more negative impact on the OHRQoL, primarily concerning dental function and social aspects. It was concluded that patients who completed orthosurgical treatment presented the benefit of less acute impacts on the OHRQoL, better self-perception of the aesthetic and less severe malocclusion, when compared to patients at pre and post-surgical stages and those individuals not treated for dentofacial deformities.

Indiana University-Purdue University Indianapolis (IUPUI) / Purpose of the Study: Determine if there is an association of the CII/D2 malocclusion and genes linked to hypodontia, namely PAX9 and MSX1. Methods and Materials: One hundred probands with CII/D2 and one hundred non-CII/D2 with no hypodontia were enrolled in this study. Clinical exam, photographs, models, radiographs, and saliva were gathered. DNA was isolated from the saliva and sent for genetic analysis. Single Nucleotide Polymorphisms (SNPs) from the PAX9 and MSX1 genes were analyzed using the LightCycler® 480 to verify the presence of each with the CII/D2 malocclusion. A Hardy-Weinberg test was used to screen for genotyping errors, then a chi-square test was used to evaluate the association of the SNP genotypes. A p-value of 0.05 was considered significant. Results: The Hardy-Weinberg test showed no significant differences between observed and expected counts thus we used them for association analysis. Chi-square analysis indicated no significant association between CII/D2 and the MSX1 rs3821949 and the PAX9 1955734 genotypes. Although a p-value of 0.06 for the PAX9 rs8004560 suggested association, it was considered a grey area and insufficient to conclude that there was significant association. Since the SNP PAX9 rs8004560 was insufficient, additional statistical analysis was also performed on the PAX9 rs8004560 genotype of the CII/D2 affected subjects reported to have hypodontia of any tooth including third molars and excluding third molars. A chi-square test yielded a p-value of 0.08 on the analysis of CII/D2 with hypodontia for any permanent tooth except third molars, which suggested association, but insufficient to conclude a significant association. All other analyses indicated a lack of association of the PAX9 rs8004560 SNP. Conclusions: There is no significant association of CII/D2 and the SNPs MSX1 rs3821949 and PAX9 rs1955734. There is a suggestion that there is an association of the SNP PAX9 rs8004560 and CII/D2. There is a suggestion that there is an association of SNP PAX9 rs8004560 and CII/D2 subjects with hypodontia of any tooth except third molars.