NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"malonylcoa ligase"" "subject:"malonylation ligase""

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In vitro polyketide biocatalysis : triketide building-blocks and enzymology

Harper, Andrew David 08 October 2013 (has links)
Polyketide products are useful compounds to research and industry but can be difficult to access due to their richness in stereogenic centers. Type I polyketide synthases offer unique engineering opportunities to access natural stereocontrol and resultant complex compounds. The development of a controlled in vitro platform based around type I polyketide synthases is described. It has been used to produce a small library of polyketide fragments on an unprecedented and synthetically-relevant scale and explore polyketide synthase enzymology. / text
In vitro
Cell-free
Preparative
Polyketide
Polyketide synthase
Ketoreductase
Malonyl-CoA ligase
MatB
Enzymology
Chiral building blocks
Chiral synthons
Diketide
Triketide
Lactone
Ketolactone
Natural products
Secondary metabolism
Secondary metabolite
Modular
Type I polyketide synthase
Biosynthesis
Streptomyces coelicolor
Saccharopolyspora erythraea
Bacillus subtilis
Streptomyces nodosus
Saccharomyces cerevisiae
Streptomyces antibioticus
Streptomyces venezuelae
Saccharopolyspora spinosa
Streptomyces fradiae

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