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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 81 to 82 of 82 (0.16 seconds)Spelling suggestions: "subject:"embrane potential"" "subject:"5membrane potential""
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Studium činnosti mikrobiálních MDR-pump pomocí fluorescenčních sond: stanovení účinku potenciálních inhibitorů / Study of the performance of microbial MDR pumps by fluorescent probes: effect of potential inhibitorsKodedová, Marie January 2011 (has links)
The current increased use of antifungal agents has resulted in the development of resistance to these drugs. Search for new antifungals with different mechanisms of action overcoming the multidrug resistance is thus underway. Surface-active antifungals have the advantages of minimizing host toxicity and the emergence of drug resistance. We have developed a fluorescence method based on the use of the potentiometric fluorescent probe diS-C3(3), substrate of two major S. cerevisiae MDR pumps, Pdr5p and Snq2p. It allows us to monitor with high sensitivity and in real time changes in the activities of both pumps and also in membrane potential. We present here an efficient strategy for identifying pump inhibitors with minimal side effects on membrane integrity, and compare the potencies of different inhibitors towards MDR pumps. New efficient inhibitors of MDR pumps could potentially be used in conjunction with current antimicrobials that are MDR pump substrates. The method can be also used to determine the mechanism of action of surface-active drugs and their lowest effective concentrations.
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IL-10 and TGF-beta Increase Connexin-43 Expression and Membrane Potential of HL-1 Cardiomyocytes Coupled With RAW 264.7 MacrophagesCox, Cora B. 02 September 2021 (has links)
No description available.
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