The purpose of this research was to examine some of the factors which may affect body composition of postmenopausal women. The effect of estrogen, physical activity, diet and lifestyle were examined in 9 women receiving estrogen replacement therapy and 11 women not using this drug. For 3 consecutive days, the subjects collected 24-hour urine samples and recorded their dietary intake. Body fat was estimated by obesity indices based on height and weight and a regression equation based on abdominal skinfold, abdominal circumference and bideltoid diameter (Young, 1964). Lean body mass (LBM) was estimated from urinary excretion of creatinine (Forbes & Bruining, 1976). Physical activity and lifestyle were assessed by a self-administered questionnaire. Age, height, physical activity, diet and lifestyle were similar for the two groups. Estrogen users were heavier than non-users (p < 0.05) and as a group had a higher prevalence of obesity. Percent body fat and LBM also tended to be higher in the estrogen users than in the non-estrogen users. The weight difference between the two groups was already present at age 25 years and persisted through the subsequent 30-year period. All 20 subjects maintained their weight between ages 25 and 35 years, thereafter, increasing in weight significantly (p < 0.05) by decade through age 55 years. For all 20 subjects no correlation was found between energy intake and any measure of obesity or body fatness. Obesity was unrelated to energy consumption. Physical activity did not correlate significantly with any estimate of body composition. Energy intake showed an inverse correlation with hours spent watching television (r = -0.82, p < 0.002). Nutrient intake for most women was adequate; however, calcium intake in women not receiving estrogen replacement therapy may be insufficient. / Graduation date: 1987

Background: The use of chemotherapy and endocrine therapies in the treatment of pre-menopausal women with breast cancer may result in menopausal symptoms, permanent infertility or the need to delay pregnancy. This series of studies investigates the fertility- and menopause-related information needs of pre-menopausal women with a diagnosis of early breast cancer (Studies 1 and 2) and the benefits women need to make undergoing adjuvant endocrine therapies worthwhile (Study 3). Method: Study 1 is a qualitative study of 24 women and Study 2 a survey study amongst 228 women. Study 3 included a subset of 102 women from the sample involved in Study 2 who had been treated with endocrine therapies for a minimum of three months. To be eligible, women had to be aged 40 years or younger (Study 2 and 3) when diagnosed with early stage breast cancer, and be 6-60 months post-diagnosis at the time of participation. For Study 2, participants completed a mailed self-report questionnaire that included a fertility- and menopause-related information needs survey, and standardized measures of distress, quality-of-life, menopausal symptoms and information preferences. For Study 3, participants were asked to complete a face-to-face interview. Results: Study 1 showed that many women thought that the information they had received in the past about fertility and menopausal symptoms was either insufficient or unavailable. Some women felt that, while information on fertility and menopause issues had not been paramount at the time of diagnosis, it became increasingly important after diagnosis. Study 2 showed that 71% of participants discussed fertility-related issues with a health professional as part of their breast cancer treatment and 86% discussed menopause-related issues. Consultation with a fertility or menopause specialist was the most preferred method of obtaining this information. Study 3 demonstrated that the majority of participants considered adjuvant endocrine therapy worthwhile for a 2% absolute gain in survival rates and for a 6-month gain in life expectancy. Conclusions: The results of this series of studies suggest that younger women have unmet needs for fertility- and menopause-related information. Women with early breast cancer who had received adjuvant endocrine therapies judged modest survival gains sufficient to make adjuvant endocrine therapy worthwhile.

The purpose of this study was to determine if surgically-induced menopause in younger women affects substrate utilization during submaximal exercise while controlling for other potential confounds. METHODS: Thirteen untrained female subjects (33-50 years old) were recruited: oophorectomized (Group O = 5) and premenopausal controls (Group C = 8). Two separate visits included: body composition and maximal treadmill exercise test; followed by substrate utilization via open-circuit spirometry during 45 minutes of treadmill walking at 50% VO2max. RESULTS: When controlling for multiple variables affecting whole-body substrate utilization (age, VO2max, physical activity, body composition, fasting glucose, menstrual phase and diet), there was no difference in substrate utilization between pre- and postmenopausal women as measured by respiratory exchange ratio (RER) (0.83 ± 0.04 v 0.84 ± 0.03, p=0.47). CONCLUSIONS: Menopausal status does not appear to have an effect on substrate utilization during submaximal exercise in younger women. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2015. / FAU Electronic Theses and Dissertations Collection

In light of exceptionally delayed reproductive senescence exhibited by a 64 year old female chimpanzee (Pan troglodytes) housed in Florida, endocrinal analyses meant to determine the state of her current reproductive viability were conducted. Urine was collected from the study subject for a period of 88 days spaced within an interim of roughly 6 months and the specimens were sent to the Hominoid Reproductive Ecology Laboratory for assessment. Additional data was collected from three control females in order to provide a basis of comparison against the hormonal markers present in the geriatric study animal. Results indicate that the geriatric female does not presently appear to be cycling, but nor does she exhibit signs of complete reproductive cessation. This could signify that Pan troglodytes adheres to a pattern of reproductive aging not necessarily shared by Homo sapiens, which has further implications for the evolutionary trajectory of menopause in the human female. / by Christina T. Cloutier. / Thesis (M.A.)--Florida Atlantic University, 2010. / Includes bibliography. / Electronic reproduction. Boca Raton, Fla., 2010. Mode of access: World Wide Web.

Conclusion 1. The results of the research partly supported hypothesis 1a. There was a significant reduction in both endothelium-dependent arterial relaxation following a surgical menopause. The results of the research partly supported hypothesis 1b. There was a significant reduction in endothelium-dependent arterial relaxation but no significant effect on endothelium-independent arterial relaxation. / Conclusion 2. The results of the research partly supported hypothesis 2a. The addition of unopposed oestrogen significantly improved endothelium-dependent but not endothelium-independent arterial relaxation. The results of the research supported hypothesis 2b. The addition of oestradiol combined with progestogen (norethisterone acetate) reversed the reduction in arterial relaxation caused by a surgical menopause. The results of the research partly supported hypothesis 2c. The addition of tibolone reversed the reduction endothelium-dependent but not endothelium-independent arterial relaxation. The results of the research partly supported hypothesis 2d. The addition of oestradiol combined with a progestogen (norethisterone acetate) reversed the reduction in endothelium-dependent but not endothelium-independent arterial relaxation. / Conclusion 3. The results of the research partly supported hypothesis 3a. Endothelium-dependent arterial relaxation but no endothelium-independent arterial relaxation was improved after the addition of menopausal hormone therapy using oestrogen combined with a progestogen in a continuous manner. The results of the research did not support hypothesis 3b. Neither endothelium-dependent arterial relaxation nor the endothelium-independent arterial relaxation was improved by cyclical menopausal HT. / Conclusion 4. The results of the research did not support hypothesis 4. The addition of menopausal hormone therapy using combined oestrogen with progestogen did not improve arterial relaxation in postmenopausal women with established coronary heart disease. / Hypothesis 2. This hypothesis examined three different types of commonly used menopausal HT. That unopposed oestrogen (2a), oestrogen combined with a progestogen (2b and 2d) or a synthetic steriod that has oestrogenic, progestogenic as well as androgenic activity (tibolone, 2c), reverse the reduction in arterial relaxation following menopause in Hong Kong Chinese women. / Hypothesis 3. That menopausal hormone therapy using oestrogen combined with progestogen given in either continuous (3a) or cyclical (3b) regimens improves arterial relaxation in postmenopausal Hong Kong Chinese women. / Hypothesis 4. That menopausal hormone therapy using combined oestrogen with progestogen improves arterial relaxation in postmenopausal Hong Kong Chinese women with established coronary heart disease. / Menopausal HT can in general at least partially reverse changes in arterial relaxation in postmenopausal women. Different types of menopausal HT exhibit different effects on arterial relaxation. In healthy vessels, menopause HT mainly reverses the endothelium-dependent vascular effect, but it remains unclear how menopausal HT affects the endothelium-independent vascular effect. However, with established coronary heart disease, menopausal HT cannot reverse the changes in vascular reactivity. / Summary. Menopause results in a reduction in arterial relaxation. However, GnRHa temporarily induced menopause in young women, the endothelium-independent vasodilatation was not impaired. This difference can be partly explained by the difference in age as vascular reactivity is age dependent. Secondly, GnRHa works with an initial phase of increase in oestrogen production resulting in a shorter duration of hypo-oestrogenism resulting in the lack of impairment on endothelium-independent vasodilatation. / This thesis tested the following hypotheses: Hypothesis 1. That vascular reactivity decreases after the menopause as shown in premenopausal Hong Kong Chinese women with either a surgical (1a) or a medically induced (1b) menopause. / This thesis will examine the effects of menopause and menopausal HT on arterial reactivity which is an indirect measurement of vascular function. Previous studies have shown that oestrogen is a potent coronary artery vasodilator, and this effect may be mediated via both endothelium-dependent and endothelium-independent mechanisms. One method of assessing vascular reactivity is to use ultrasound measurement of changes in brachial artery diameter in response to certain stimuli. Using this technique, changes in both endothelium-dependent and endothelium-independent vasodilatation can be measured. Increased rather than decreased arterial relaxation after stimulus can be viewed as a favourable response. / Yim, So-fan. / Adviser: C. J. Haines. / Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 5873. / Thesis (M.D.)--Chinese University of Hong Kong, 2006. / Includes bibliographical references (p. 159-194). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / School code: 1307.

We investigated the relationship between calcium and protein intake and bone loss over a one-year period in 99 early postmenopausal women (1-36 months) aged 51.3 �� 0.31 years. Bone mineral density (g/cm��) of the left hip (total hip, femoral neck, greater trochanter) and lumbar spine (L1-L4) as well as body composition were assessed using dual energy x-ray absorptiometry. Dietary intake of calcium and protein was assessed using a 100-item Block Food Frequency Questionnaire. A physical activity questionnaire was also completed by the subjects to estimate energy expenditure. Paired t-tests revealed that there were no significant differences between baseline and month 12 physical characteristics except for percent fat which increased from 31.99 �� 0.60% to 32.44 �� 0.61% (p=.009). At month 12, bone mineral density decreased significantly at the femoral neck (-0.97 �� 0.31%) and total hip (-0.55 �� 0.24%). The average calcium, protein and calcium to protein ratio intake for the group was 1129.88 �� 46.22mg/day, 57.88 �� 1.93g/day and 20.10 �� 0.71m/g, respectively. Partial correlation analyses showed no significant relationships between change in bone mineral density and average intakes for calcium, protein, or the calcium to protein ratio. After adjusting for hormone replacement status, lean body mass and months post menopause, analysis of covariance revealed that there were no significant differences between groups when intakes of calcium, protein and the calcium to protein ratio were separated into "above recommended" and "below recommended" categories (above or below 1000/1500mg/day, 50g/day, 20:1 mg/g/day, respectively). Our results suggest that consuming adequate amounts of calcium and protein does not appear to significantly slow bone loss after 12 months in early postmenopausal women. / Graduation date: 2003

Falls in the older population have devastating consequences on the psychological and physiological health of the individual. Due to the complexity of interacting factors associated with ageing, pathology and falling episodes, determination of a primary cause or set of causes has been difficult to establish. Deficits in components of neuromuscular control have been widely studied with the coordinated interaction of sensory and motor system components being presented as a fundamental factor in the reduction of falling episodes. A causal relationship between deficits in vitamin D status and falling episodes has also been suggested. Furthermore, a relationship between poor vitamin D status, falling episodes and poor neuromuscular performance has been reported. The aims of the current study were designed to advance understanding in three aspects of the problem of falls prevention. Firstly an examination of the reliability of testing procedures commonly used in assessment of falls risk was undertaken. The Physiological Profile Assessment (PPA) testing procedure was selected as a commonly used tool and the reliability of its various components (sensory, motor and balance) was undertaken as an independent assessment of this approach to assessing falls propensity. Secondly, a case control study of fallers and non fallers was undertaken in which the neuromuscular tests evaluated in the reliability study were used to assess differences in neuromuscular control. The influence of vitamin D status on these measures was also considered. Thirdly, a 12-month randomised controlled trial of vitamin D/calcium supplementation or placebo/calcium was undertaken to identify the effect on falls outcome and individual measures of neuromuscular control.