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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 2 of 2 (0.04 seconds)Spelling suggestions: "subject:"mesocate"" "subject:"deslocate""
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Ruthenium-containing linear helicates and mesocates with tuneable p53 selective cytotoxicity in colorectal cancer cellsAllison, S.J., Cooke, D., Davidson, F.S., Elliott, P.I.P., Faulkner, R.A., Griffiths, H.B.S., Harper, O.J., Hussain, O., Owen-Lynch, P.J., Phillips, Roger M., Rice, C.R., Shepherd, S.L., Wheelhouse, Richard T. 04 June 2018 (has links)
Yes / The ligands L1 and L2 both form separable dinuclear double‐stranded helicate and mesocate complexes with RuII. In contrast to clinically approved platinates, the helicate isomer of [Ru2(L1)2]4+ was preferentially cytotoxic to isogenic cells (HCT116 p53−/−), which lack the critical tumour suppressor gene. The mesocate isomer shows the reverse selectivity, with the achiral isomer being preferentially cytotoxic towards HCT116 p53+/+. Other structurally similar RuII‐containing dinuclear complexes showed very little cytotoxic activity. This study demonstrates that alterations in ligand or isomer can have profound effects on cytotoxicity towards cancer cells of different p53 status and suggests that selectivity can be “tuned” to either genotype. In the search for compounds that can target difficult‐to‐treat tumours that lack the p53 tumour suppressor gene, [Ru2(L1)2]4+ is a promising compound for further development.
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C<sub>2</sub>-Symmetric Pyrazole-Bridged Ligands and Their Application in Asymmetric Transition-Metal CatalysisBöhnisch, Torben 23 July 2015 (has links)
No description available.
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