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On the nature of the enzyme defect(s) in GM1-gangliosidosis types 1, 2 and 3Miller, Jack January 1974 (has links)
No description available.
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612 |
Examination of the Effects of Sex and Sex Hormones on Monounsaturated Fatty Acid BiosynthesisMarks, Kristin Adele January 2012 (has links)
Monounsaturated fatty acids (MUFA) have been viewed as either beneficial or neutral with respect to health; however, recent evidence suggests that MUFA may be associated with obesity and cardiovascular disease. Sex differences in MUFA composition have been reported in both rats and humans that may be mediated by sex hormones. Therefore, differences in fatty acid and enzyme expression were examined in male and female rats. HepG2 cells treated with 17β-estradiol, progesterone and testosterone (0, 10, 30 and 100 nM), and ovariectomized female rats with hormone implants (sham, no treatment, estradiol, progesterone, and estradiol plus progesterone) examined the role of sex hormones in MUFA metabolism. MUFA concentrations were determined by gas chromatography. The mRNA and protein expression of stearoyl-CoA desaturase and elongase 6, key enzymes involved in MUFA biosynthesis, were measured by real-time PCR and immunoblotting, respectively. Elongase 6 protein expression was higher in females as compared with males, increased with estradiol and progesterone treatment of HepG2 cells, and was higher in ovariectomized rats treated with estradiol. Elongase 6 expression was also decreased in HepG2 cells treated with testosterone. In contrast, the expression of stearoyl-CoA desaturase did not appear to be associated with sex or sex hormones in HepG2 cells, although ovariectomized rats treated with estradiol plus progesterone had increased stearoyl-CoA desaturase protein levels compared with sham controls. Sex differences and differences after hormonal treatments were observed in the fatty acid concentrations of MUFA and immediate MUFA substrates including 16:0, 16:1n-7, 18:0, 18:1n-7 and 18:1n-9. These differences in MUFA are consistent with the changes in elongase 6 expression. The effect of sex and hormone status on elongase 6 has not been previously examined, but these results suggest elongase 6 is an important factor in determining MUFA composition. These sex and hormonal differences in MUFA composition may contribute to sex differences in obesity and cardiovascular disease. Further work examining other factors involved in MUFA composition including oxidation, synthesis of complex lipids and the effect of diet is required.
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613 |
Plasma amino acids in epilepsyAslam Janjua, Najma. January 1982 (has links)
No description available.
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614 |
Acquisition of haemoglobin-bound iron by Histophilus somniTremblay, Yannick January 2005 (has links)
Ovine (strains 9L and 3384Y) and bovine (strains 649, 2336 and 8025) isolates of Histophilus somni were investigated for their ability to acquire iron from haemoglobin (Hb). Bovine isolates were capable of utilizing bovine, but not ovine, porcine or human Hb as a source of iron. Ovine isolates could not obtain iron from Hb. Bovine isolates bound bovine, ovine, and human Hbs by means of the same iron-repressible receptor(s) and produced a ~120-kDa iron-repressible, outer membrane protein. Using PCR approaches, an iron-regulated operon containing hugX and hugZ homologues and a gene (hgbA) that encodes a TonB-dependent, Hb-binding proteins were identified in strains 649, 9L and 3384Y. In strains 9L and 3384Y, HgbA is truncated offering a possible explanation for their lack of utilization of Hb as an iron source. In strains 2336 and 8025, expression of HgbA was also subject to a form of phase variation.
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615 |
The effect of fibre on the utilization of thiamineMilling, Edith Muriel 06 1900 (has links)
Graduation date: 1944
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616 |
Comparative effects of sterculic and malvalic acids on the hepatic microsomal cytochrome P-450 system of rainbow trout (Salmo gairdneri)Bailey, Marcia Lynn 04 December 1978 (has links)
Graduation date: 1979
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Concentrations of free and total cholesterol in human blood fractionsSmith, Elveda 11 May 1961 (has links)
Graduation date: 1961
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618 |
Metabolism of (1-¹⁴C) linolenic acid in coho salmon, Oncorhynchus kisutchParker, Robert S. 05 May 1978 (has links)
Graduation date: 1978
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619 |
Studies in the mineral metabolism of the Hawaiian crab, Podophthalmus vigil (Fab.) throughout the ecdysis cycleSather, Bryant Thomas January 1965 (has links)
Typescript. / Thesis (Ph. D.)--University of Hawaii, 1965. / Bibliography: leaves 138-147. / vii, 147 l mounted illus., tables
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620 |
Molecular modelling of UDP Glucuronosyltransferases /Sorich, Michael Joseph. Unknown Date (has links)
Thesis (PhD)--University of South Australia, 2003.
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