Large summertime proliferations (or blooms) of the noxious filamentous cyanobacterium Lyngbya majuscula have been observed in the coastal marine waters of Moreton Bay, Queensland. This photosynthetic organism is believed to have a high iron requirement and preliminary studies have shown that the presence of organically complexed iron stimulates growth. Since there is no evidence that Lyngbya produces siderophores to aid iron acquisition, it has been hypothesized that this organism may acquire iron via reduction of ferric complexes to the typically more labile, ferrous form. Both the phylogenetic diversity of the genus Lyngbya and the iron metabolism of L. majuscula are examined in this thesis. Software was developed to assist in the design of peR primers that targeted l6S rRNA, rpoB and Highly Iterated Palindrome (HIP) genetic structures and the subsequent phylogenetic analysis. The mechanism of iron acquisition by L. majuscula and the influence of organic complexation of iron were investigated using radioisotope and chemiluminescence-based techniques. Molecular techniques were also used to investigate the genetics of iron metabolism of L. majuscula. Results of the l6S rRNA analysis indicate that the morpho-genus Lyngbya encompasses a large genetic diversity within the cyanobacteria that is consistent with its reported metabolic and ecological diversity. Five discrete lineages comprised of organisms that fit the morophological definition of Lyngbya were discovered in this analysis. L. majuscula utilises endogenously-produced superoxide as a reductant of ferric complexes to produce the more labile ferrous forms. The nature of the organic complexes has been shown to determine the efficacy of this mechanism. A model of iron acquisition by these reductive processes was developed and was shown to generally describe all known methods of reduction-mediated iron acqUIsItIOn. Finally, the genetics of iron metabolism of L. majuscula was found to be consistent with the mechanism we propose, including the discovery of a component of a ferrous iron uptake mechanism.

Bibliography: leaves 298-334. / xxxi, 334, [3] leaves, [18] leaves of plates : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Provides insight into the mechanism by which dihydrotestosterone (DHT) and estrogen effect osteoblast and osteoclast bone cell activities. Also demonstrates the differential effects of DHT on bone cell activities in estrogen sufficient and estrogen deficient rats suggesting that there is an interaction of estrogens and androgens on bone cell metabolism in the female rat. / Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 1998?

Erratum pasted inside back end paper. / Bibliography: leaves 174-201. / xvii, 202, [77] leaves, [8] leaves of plates : ill. (chiefly col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Establishes that the herbicide carbetamide degrades rapidly upon repeated application to soil, when compared to a previously untreated soil. / Thesis (Ph.D.)--University of Adelaide, Dept. of Crop Protection, 1997

Amendements: leaves 252-254. / Copies of author's previously published articles inserted. / Bibliography: leaves 226-251. / vi, 254 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenytoin and proguanil. / Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2000

vi, 152 leaves, appendix : ill. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.1973) from the dept. of Zoology, University of Adelaide

221 leaves : graphs, tables ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.1976) from the Dept. of Biochemistry, University of Adelaide

xvii, 194 leaves : ill. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Human Physiology and Pharmacology, 1971

xix, 84 leaves : tables, graphs ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Agricultural Biochemistry, 1979

163 leaves : ill. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Zoology, 1970

Typescript (photocopy) / v, 132 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Human Physiology, 1979