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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.052 seconds)

Spelling suggestions: "subject:"methylphenidate wide effects"" "subject:"methylphenidate side effects""

1

The effect of early psychostimulant treatment on abuse liability and dopamine receptors

Villafranca, Steven Wayne 01 January 2005 (has links)
Examines whether the reinforcing properties of drugs of abuse were altered in adulthood by methylphenidate, more commonly known as Ritalin. Subjects were 108 rats of Sprague-Dawley descent (Harlan). Methylphenidate, or saline was administered daily to the subjects from the postnatal period (11-20 days old). The rats preference for morphine during early adulthood was measured using conditioned place preference. The number of dopamine D₂ receptors was measured in each rat and the correlation between receptor number and morphine preference was determined. Results indicate that rats pretreated with methylphenidate showed greater preference for morphine than saline pretreated rats and suggests that exposure to methylphenidate during the postnatal period increases the rewarding value of morphine.
Drug abuse Forecasting
Methylphenidate Side effects
Dopamine Receptors Pathophysiology
Drug abuse Animal models
Drug abuse Animal models
Drug abuse Forecasting
Methylphenidate Side effects.
Biological Psychology
Substance Abuse and Addiction
2

Effect of preweanling methylphenidate exposure on the induction, extinction and reinstatement of morphine-Induced conditioned place preference in rats

Kucher, Kellie Lynn 01 January 2005 (has links)
This study examined the effect of preweanling methyphenidate exposure on later drug reward. We examined the induction, extinction, and reinstatement of morphine induced conditioned place preference (CPP) in rats that received methylphenidate pretreatment during the preweanling period.
Drug abuse Forecasting
Methylphenidate Side effects
Laboratory animals
Rats Physiology
Animal experimentation
Attention-deficit hyperactivity disorder
Animal experimentation
Attention-deficit hyperactivity disorder
Drug abuse Forecasting
Laboratory animals
Methylphenidate Side effects
Rats Physiology.
Biological Psychology

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