The Hyp (hypophosphatemic) mouse, a murine homologue of X-linked hypophosphatemia (XLH) in man, is a Mendelian disorder of phosphate (Pi) homeostasis. The mutant genotype is characterized by abnormal Pi transport at the brush border membrane (BBM) of the proximal tubule and a defect in renal metabolism of vitamin D$ sb3$. The exact nature of these defects has not been elucidated. / In order to determine if the defect is intrinsic to the renal cell or dependent upon an extrinsic humoral factor, I established primary cultures of renal epithelial cells from normal and Hyp mouse kidney. The cultures demonstrated several differentiated properties of epithelial cells of the renal proximal tubule, the site of the Pi transport defect in the Hyp mouse. / Primary cultures initiated from Hyp mice had decreased Pi transport (expressed as an uptake ratio, Pi/$ alpha$-MG), and increased production of 24,25 dihydroxyvitamin D$ sb3$. These results provide evidence for the intrinsic nature of the primary defect in the Hyp mouse. / This appears to be the first time that expression of a mutant transport gene has been demonstrated in cultured renal cells.

Thesis (M.S. in horticulture)--Washington State University, May 2009. / Title from PDF title page (viewed on July 28, 2009). "Department of Horticulture and Landscape Architecture." Includes bibliographical references (p. 51-58).

Thesis (M.A.)--Central Connecticut State University, 2004. / Thesis advisor: James Mulrooney. " ... in partial fulfillment of the requirements for the degree of Master of Arts in Cell and Molecular Biology." Includes bibliographical references (leaves 36-38). Also available via the World Wide Web.

Thesis (M.A.)--Central Connecticut State University, 2004. / Thesis advisor: Thomas King. " ... in partial fulfillment of the requirements for the degree of Master of Arts in Biological Sciences: Cell and Molecular Biology." Includes bibliographical references (leaves 32-33). Also available via the World Wide Web.

Thesis (M. Phil.)--University of Hong Kong, 1995. / Includes bibliographical references (leaf [94]-105).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1955. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves [97]-105).

Thesis (Ph. D.)--Rutgers University, 2008. / "Graduate Program in Toxicology." Includes bibliographical references (p. 171-202).

Published also as Thesis (Ph. D.)--Columbia University, 1918. / Columbia university contributions to philosophy and psychology, vol. XXVI, no. 4.

Thesis (M. Sc.)--Carleton University, 1988. / Also available in electronic format on the Internet.

Published also as thesis (PH. D.) Columbia university, 1918. / Columbia university contributions to philosophy and psychology, vol. XXVI, no. 4.