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Studies towards the total synthesis of (-)-kendomycin /Smits, Helmars. January 1900 (has links)
Thesis (Ph. D.)--Oregon State University, 2007. / Printout. Includes bibliographical references (leaves 126-130). Also available on the World Wide Web.
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Physiology of a kerosine-oxidizing PenicilliumHerring, Craig Maynard, 1945- January 1970 (has links)
No description available.
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Preparation and biological evaluation of the loloatins and their analogues /Chen, Heru. January 2002 (has links)
Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2002. / Includes bibliographical references. Also available in electronic version. Access restricted to campus users.
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Penicillin acyl-group transfer and hydrolysis in microorganismsPruess, David Louis, January 1967 (has links)
Thesis (Ph. D.) University of Wisconsin, 1967. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Novel secondary metabolites isolated from selected marine invertebratesMorris, Sandra Anne January 1990 (has links)
A study of the secondary metabolism of two northeastern Pacific sponges and two Sri Lankan nudibranchs has led to the isolation of thirteen new and one previously known natural products. The structures of all of the compounds were determined by a combination of spectroscopic data analysis and chemical interconversions.
A study of the chemistry of the northeastern Pacific sponge Hexadella sp. has resulted in the isolation of six new brominated alkaloids. Two of these, hexadellins A (77) and B (78), are derived from dibromotyrosine. The structures of compounds 77 and 78 were determined via their acetylated derivatives 79 and 80. Four compounds possessing novel bis(indole) structures have also been isolated. Topsentin B2 (74) was isolated as a mixture of two slowly interconverting tautomers, 74a and 74b. Methylation of 74 resulted in the production of trimethyltopsentin B2 (75); the structure of 75 was determined spectroscopically. The structures of dragmacidons A (81), B (82), and C (83) were determined by a combination of spectral data interpretation and chemical interconversions. Dragmacidon C (83) was originally incorrectly assigned as 88; the correct structure was determined based upon synthesis of the model compound 94. Compounds 77 and 78 possess antimicrobial activities. Compounds 74 and 81 show considerable cytotoxic and antineoplastic activities.
Five new triterpene glycosides have been isolated from the northeastern Pacific sponge Xestospongia vanilla. The structures of isoxestovanin A (125), xestovanin C (127), dehydroxestovanin A (129), epi-dehydroxestovanin A (131), and dehydroxestovanin C (132) were all determined by a combination of spectral data interpretation and chemical interconversions. These compounds all contain the deoxy sugars L-rhamnose and D-fucose. Isoxestovanin A (125) possesses a new carbon skeleton and xestovanin C (127) and dehydroxestovanin C (132) possess linear
trisaccharide fragments which have not been previously encountered in triterpene
glycosides isolated from X. vanilla.
The Sri Lankan nudibranch Chromodoris glenei has yielded the known compound 12-desacetoxyshahamin C (153) and the new metabolite shahamin K (155). Both compounds possess dendrillane diterpene skeletons. The compound chromodorolide B (156) was isolated from specimens of Chromodoris cavae. It is only the second known diterpene natural product possessing the chromodorane skeleton. / Science, Faculty of / Chemistry, Department of / Graduate
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Production of unique metabolites by the marine dinoflagellate Prorocentrum minimumTrick, Charles Gordon January 1982 (has links)
Marine phytoplankton produce extracellular metabolites which may be important in controlling the interactions among species or the competition for a limiting nutrient. While the absolute amount of these metabolites may be small compared to the primary organics released by the phytoplankton cell, the control of the production of these unique metabolites may be an important factor in the ecology of the producing species. These compounds have not been extensively studied due to the difficulty in isolating these minute quantities from seawater.
In this thesis, two externally produced metabolites have been investigated. The concentration of 1 -(2,6,6-trimethyl-4-hydroxycyclohexenyl)- 1,3-butanedione, a nor-caroteniod commonly referred to as the β-diketone, was quantitatively determined during the exponential and senescent stages of growth of Prorocentrum mi n imum in P-, N-, and iron-deficient batch cultures. The β-diketone was released extracellularly in a single 'pulse' during the stationary stage of growth. Several factors such as temperature, irradiance, type of nutrient-deficiency (N, P, or Fe), and the ambient nitrate concentration were important in establishing the amount of the β-diketone produced. The environmental factors did not influence the temporal pattern of production, only the absolute amount of the β-diketone produced. The limits of the range of production of the β-diketone were narrower than the range of maximum growth for any environmental influence. The inhibition of growth and the heterotrophic uptake of glucose by marine bacteria,
demonstrated the antibacterial properties of the β-diketone.
The second extracellular organic examined was prorocentrin. Prorocentrin is the extracellular siderophore produced by Prorocentrum minimum, P. mariae-lebouriae, and P.gracile. Functionally similar compounds are produced by Thalassiosira pseudonana and Dunaliella tertiolecta. This study is first to characterize this type of high-affinity iron (111)-transport system in marine eukaryotic phytoplankton.
The pattern of siderophore production by all species is the same, although the absolute amount of the material produced is species specific. There is no intracellular or extracellular siderophore production under iron-sufficient culture conditions. When iron was deficient there was a short period of rapid extracellular siderophore production during the stationary stage of growth. The intracellular prorocentrin concentration was very low which suggests that de novo synthesis of the prorocentrin occurs just prior to extracellular release. The persistence of the extracellular siderophore in the culture medium was brief. There was an increase in the in vivo fluorescence following the loss of the siderophore from the medium. The increase in in vivo fluorescence was not accompanied by an increase in cell concentration. An hypothesis concerning the mechanism of the iron-uptake system is proposed.
Procedures for the isolation and characterization of prorocentrin are presented. Prorocentrin appears to be a tri-hydroxamate siderophore with a molecular weight between 560 and 590 daltons. The iron-prorocentrin complex is stable over a
wide pH range. / Science, Faculty of / Earth, Ocean and Atmospheric Sciences, Department of / Graduate
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An integrative approach to understanding pyoluteorin biosynthesis in the biological control bacterium Pseudomonas fluorescens Pf-5Nowak-Thompson, Brian 14 March 1997 (has links)
Graduation date: 1997
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Structural and preliminary biosynthetic studies on new metabolities produced by Streptomyces murayamaensis mutant MC2Hassan, Awatef Mahdi 15 July 1994 (has links)
Graduation date: 1995
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Genetic studies of xanthomonas maltophiliaMcCallum, Mark Edward 12 1900 (has links)
No description available.
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Genetic studies of P̲s̲e̲u̲d̲o̲m̲o̲n̲a̲s̲ m̲a̲lt̲o̲p̲h̲i̲l̲i̲a̲White, Patricia McGuire 08 1900 (has links)
No description available.
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