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Conservation and evolution of microsatellites in vertebrate genomes : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biological Sciences in the University of Canterbury /Buschiazzo, Emmanuel. January 2008 (has links)
Thesis (Ph. D.)--University of Canterbury, 2008. / Typescript (photocopy). Includes bibliographical references (leaves 192-230).
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Genotyping of gestational trophoblastic diseaseLai, Yau-lin, Caroline, 黎幼蓮 January 2001 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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Molecular ecology of Dawson's burrowing bee Amegilla dawsoni (Hymenoptera: Anthophorini) /Beveridge, Maxine. January 2006 (has links)
Thesis (M.Sc.)--University of Western Australia, 2006.
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Genetic interpretation of microsatellite polymorphism in Pacific salmon : case studies in population genetics and kinship analysis /Olsen, Jeffrey B. January 1999 (has links)
Thesis (Ph. D.)--University of Washington, 1999. / Vita. Includes bibliographical references (leaves [98]-108).
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Development and use of molecular tools in Fragaria /Njuguna, Wambui. January 1900 (has links)
Thesis (Ph. D.)--Oregon State University, 2010. / Printout. Includes bibliographical references (leaves 260-285). Also available on the World Wide Web.
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Genetic studies of North American bear populations using microsatellitesPaetkau, David Henry, January 1997 (has links) (PDF)
Thesis (Ph. D.)--University of Alberta, 1997. / Includes bibliographical references.
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Genetic differentiation in Alewife populations using microsatellite lociChilakamarri, Sunita R 31 May 2005 (has links)
"Local genetic adaptation and homing behavior in anadromous fish favors the formation of local populations across their geographic range of distribution. Spawning- and natal-site fidelity repeated over generations restricts gene flow and allows genetic differences to accumulate resulting in reproductive isolation. This leads to progressive genetic differentiation and population structuring among different river populations. Alewife, Alosa pseudoharengus, are anadromous fish which are estimated to have high rates of reproductive fidelity and hence might show population structuring among different breeding streams. Alewife are fish of economic importance since they have both commercial and recreational value. Alewife populations have been declining over the past decades and conservation measures to restore the populations have been implemented. Since maintaining genetic integrity of natural populations is one of the main concerns, identification of population structure can assist in designing appropriate restocking programs. In this study, I used microsatellite markers developed for shad to study population structuring in alewife. Samples were collected from two sites in Connecticut and one in Lake Michigan and genetic differentiation among these populations was estimated using five microsatellite loci. My studies indicate that microsatellite loci developed for shad can be used for alewife. Results from this preliminary study indicated subtle but significant genetic differentiation among populations. This suggests that care should be taken when restocking alewife from different sites in order to maintain genetic diversity among these populations."
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The ontogeny of myogenic regulatory factor expression during muscle differentiation in the biceps femoris and pectoralis major muscles of the chicken Appendix I. Isolation and characterization of microsatellite DNA in rainbow trout ; Appendix II. Analysis of myostatin expression during embryogenesis of the rainbow trout /Sarver, Amy G. January 2001 (has links)
Thesis (M.S.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains vii, 78 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 52-62).
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An immunohistochemical and microsatellite analysis of nephroblastomas.Govender, Dhirendra. January 2008 (has links)
The aims of this study were: (i) to determine the association between p53, bcl-2, pRb,
p21, cyclin A and p-glycoprotein immunoexpression and prognosis, and (ii) to
determine the frequency of loss of heterozygosity and microsatellite instability at 11 p,
16q and mismatch repair gene loci and their association with prognosis, in
nephroblastomas in South African children.
There were 138 cases (111 of whom received preoperative chemotherapy) in the
immunohistochemical study and, 70 cases (48 with preoperative chemotherapy) in
the microsatellite study. The following monoclonal antibodies were used after heat
induced epitope retrieval; p53, bcl-2, pRb, p21, cyclin A and p-glycoprotein. Six
polymorphic microsatellite markers were selected from the 11p region, 5 from the 16q
region and 6 from the loci of known mismatch repair genes. Automated fluorescent
DNA technology was used in the analysis. The results of the immunohistochemical
and microsatellite studies were correlated with patient age, gender, preoperative
chemotherapy, SlOP histological classification, SlOP histological risk group,
clinicopathological stage, patient outcome and survival using X2
, Fisher's exact test,
Cox regression model and Kaplan-Meier estimates.
The majority of patients presented with advanced disease. Anaplastic tumours and
high-risk histology were associated with high disease stage. Mortality was directly
related to increasing stage and histological risk group. Multivariate analysis showed
that clinicopathological stage was the only factor significantly associated with survival
(p<0.001) (hr=5.6, 95%CI: 2.1-14.9).
High expression of p53 was more frequent in anaplastic tumours suggesting that p53
mutations are common events in this tumour type (p<0.001). Despite the strong
association with tumour histology, there was no association with stage. Although p53
expression was found to be a predictor of survival in the univariate analysis this was
not retained in the multivariate analysis. Tumours treated with preoperative
chemotherapy showed higher bcl-2 immunoreactivity (p=0.027 but lower levels of pRb
(p=0.040) and cyclin A expression (p<0.001). All anaplastic tumours showed high
expression of pRb compared to the other histological types (p=0.003). Expression of
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pRb was significantly associated with survival in the univariate analysis but not in the
multivariate analysis. High cyclin A expression was associated with high risk histology
(p<0.001). Cyclin A expression was found to be a significant predictor of survival in
both the univariate (hr=1.7; 95%CI 1.2-2.4; p=0.002) and multivariate analyses
(hr=1.7; 95%CI1.1-2.7; p=0.032). Although tumours with high risk histology were
more likely to express high levels of p-glycoprotein, this did not reach significance.
LOH at 11 p was seen in 64.7% of 68 informative cases. LOH at 11 p13 was more
frequent than LOH at 11p15. LOH for both 11p13 and 11p15 was found in 39.7% of
all tumours. MSI at 11 p was seen in 22.1 % of informative cases. The majority
showed MSI for one marker only. LOH 16q was seen in 66.7% of 66 informative
cases. MSI at 16q was seen in 16.7% of cases. LOH for 016S496 and 016S520
appear to be related to tumour histology and risk group. The most frequent locus for
LOH was 16q21-22, which is known to harbour important genes, such as, E2F4 and
E-cadherin. LOH for MMR markers was seen in 43.5% of 69 informative cases. MSI
was seen in 11.6% of tumours. In the multivariate analysis there was no significant
correlation between LOH at any of the loci studied and survival. There were no
tumours with high frequency MSI. Low frequency MSI was of no clinicopathological
significance.
The following conclusions are made: (i) p53 mutations determined by high p53
expression is a frequent finding in anaplastic tumours, (ii) Bcl-2 may play a role in the
chemoresistance of nephroblastomas, (iii) Rb gene alterations are not important in
the development of nephroblastoma and anaplasia, (iv) Cyclin A expression is an
independent predictor of survival, (v) p-glycoprotein may be responsible for the
chemoresistance in a proportion of nephroblastomas, (vi) MSI is a rare occurrence in
nephroblastoma and does not play a role in the development of nephroblastoma, (vii)
LOH at 11 p and 16q are frequent findings in nephroblastomas, (viii) LOH for the
specific 16q markers (016S496 and 016S520) may have an important prognostic role
in nephroblastoma. / Thesis (Ph.D.)-University of KwaZulu-Natal, Durban, 2008.
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Characterization, polymorphism assessment, and database construction for microsatellites from BAC end sequences of catfish a resource for integration of linkage and physical maps /Somridhivej, Benjaporn, Liu, Zhanjiang January 2007 (has links) (PDF)
Thesis(M.S.)--Auburn University, 2007. / Abstract. Vita. Includes bibliographic references.
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