This master thesis describes impacts of economic crisis on migration in the European Union. It analyzes migration flows within the European Union and from the third countries in the time period between 2004 and 2008. The goal of this thesis is to either confirm or deny the hypothesis: the number of people migrating from the southern parts of Europe to the more economically developed central and northern parts of Europe has increased as a consequence of the financial crisis in 2008. The impact of financial crisis on the intra-European migration is analyzed with a migration potential applied on an example of two countries: Italy and Germany.

The thesis aims to estimate the future migration flows from Ukraine, Belarus, and Moldova to the EU. Based on the experience of previous EU enlargements and econometric modelling using the method of Ordinary Least Squares with Fixed Effects, multiple forecasts are created. The forecasts capture the likely development of migration flows in the event of collapse of labour market restrictions as well as the case of no labour market liberalization. The results show that migration flows are expected to be moderate, posing no threats to the stability of the labour markets of EU member states. The increase of migration due to the accession to the EU is likely to be short-term, without substantial impacts in the long-run. Ukraine has the biggest migration potential and is likely to supply the highest amount of labour migration.

Today, mainframes contain a considerable portion of business applications worldwide. It is estimated that the current inventory of production COBOL running on mainframes is 150 to 200 billion lines of code. Despite the efforts to change within the mainframe environment, these mainframes, nowadays, face major problems for host organizations due to a combined set of financial, business related, technical and organizational problems. Moreover, the factors like diminishing resources (COBOL programmers), lack of documentation, inability to integrate with other systems, increasing maintenance costs, etc. have caused the organizations search for migration solutions. To overcome this problem within the context of modernization, over the years several main migration approaches that ranges from simple screen scraping methods to complete re-write of applications or re-hosting of platforms have been developed. To contribute to the solution of this overall problem, this thesis proposes a methodology framework specifically for the COBOL/CICS based mainframes. The research studies in this topic within this field are mainly focused on the technical aspects whereas our concentration is covering not only that but the other essential aspects of the problem domain. These are organizational view, project management view and process view. Within the thesis study, a special interest is given to the modernization strategy selection among migration, rewrite, packaged and do-nothing alternatives. Experimental results are also provided within the thesis to prove the usability of the approach for this selection.

This thesis aims to investigate both the causes and effects of migration in the Middle East and North Africa with a view to identifying the patterns and trends that characterize migration phenomena in the region. It is argued that migration is a significant variable to understand the economic, social and political dynamics of the development that the MENA countries have experienced since imperial and/or colonial times. In its different variants, migration has been conditioned primarily by economic vicissitudes. With the exception of the Gulf states, all of the MENA countries have experienced significant levels of immigration as well as emigration especially since the 1980s when the structural effects of the oil crisis (1973) surfaced. The Iraq-Iran War of the 1980s and the Gulf War of the 1990s enhanced the existing trends of migration. In the absence of political reform and economic restructuring, the economies of the region have rejuvenated the conditions of migration. Having drawn upon sociological theories, political histories and economic analyses to identify and discuss the patterns and trends of migration, the present study argues in complete contrast to a policy-oriented Western scholarship that migration is far from being a stimulus for economic growth across the MENA countries.

Zugl.: Osnabrück, Universiẗat, Diss., 2007. / Includes bibliographical references (p. 273-284).

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2008. / Includes bibliographical references (p. 81-85).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1975. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

This thesis discusses the economic effects of migration in the countries of European Union. This topic is very wide with a lot of related fields. The thesis explains the basic conception, typology, development, impacts and current trends in immigration flows to EU area. The focus of the second part is illegal migration and the border protection of EU. The main part is concerned with the impact of migration flows on economic growth and labour market as well as the social and demographic factors, which deal with population aging. This impact is considered within four regions of EU. The last part of the paper is occupied by EU migration policy. Within these chapters is considered also Czech Republic in relation to migration flows and the following confrontation with the others states of European Union.

The PhD thesis 'Vietnamese in Czechia and the world: migration and adaptation tendencies' sheds light on the development of international migration of the Vietnamese since the mid 20th century to the present with special emphasis on Czechia as a country of destination. The main aim is to identify the key factors that initiate international migration of the Vietnamese and how they determine main directions of these movements, affect migrants' and non-migrants' expectations and determine adaptation strategies. In this respect, the methodology of the paper is based on the combination of macro-level and micro-level approaches. Therefore, the thesis brings an analysis of main structural factors encouraging international migration of the Vietnamese such as economic development, economic and political reforms Đổi Mới and pro-emigration policy of the Vietnamese government; and also an analysis of actors' personal interpretations of these factors. The key part of the thesis is also identifying the transformation of importance of these factors depending on the stage of migration and on the socio-economic-political context of migration or migration-decision making. The paper stems from the analysis of available statistical data and legal documents, and results of three-year research, which was carried out...

Abstract: Molecular and cellular insights into IKAP and Elongator functions As the first step in the complex process of gene expression, the transcription of genes from DNA to RNA by RNA polymerase II is subject to a multiplicity of controls and is thereby the endpoint of multiple cell regulatory pathways. We focused here on the molecular and cellular functions of IKAP and by extension of Elongator complex, initially found associated with the hyperphosphorylated RNA polymerase II during the elongation stage of transcription. IKAP is required for the assembly of Elongator subunits into a functional complex. Elongator has a histone acetyltransferase (HAT) activity associated with one of its subunits, named hELP3. In agreement with a potential role in transcript elongation, Elongator is associated with nascent RNA emanating from the elongating RNA polymerase II along the transcribed region of several yeast genes and chromatin immunoprecipitation experiments have also demonstrated an association of Elongator with genes in human cells. Different mutations in the human IKBKAP gene, encoding IKAP/hELP1, cause familial dysautonomia, a severe neurodevelopmental disease with complex clinical characteristics. Affected individuals are born with the disease and abnormally low numbers of neurons in peripheral nervous ganglions. To gain insight into the role played by IKAP and the Elongator complex in the transcription of genes and concomitantly learn about the molecular defects underlying the FD, an RNA interference approach was used to deplete the IKAP protein in human cells. In yeast, disruption of ELP1 (yeast homolog of human IKAP) is known to destabilize the ELP3 catalytic subunit, which leads to loss of Elongator integrity. Our experiments performed in human cells revealed that the levels of hELP3 protein is also affected by IKAP depletion after RNAi. We took advantage of this cellular loss-of-function model to identify genes whose transcription requires IKAP, by microarray experiments. Among the identified candidates, several were previously described to be involved in cell motility, or actin cytoskeleton remodelling. Because cell motility is of crucial importance for the developing nervous system, and therefore of obvious relevance to FD, the potential role of IKAP in cell motility was characterized at the cellular level. Several cell motility/migration assays demonstrated that the IKAP depletion has functional consequences so that IKAP-depleted cells showed defects in migration. Particularly, the reduced cell motility of neuronal-derived cell lines may be highly relevant to the neurodevelopmental disorder that affects FD patients. Whether or not the defects in cell migration resulted of impaired transcriptional elongation of the IKAP-dependent genes was investigated by chromatin immuno-precipitation technique. These experiments indicated that IKAP depletion leads to a decreased histone H3 acetylation in the transcribed region of its target genes in the context of Elongator complex. These acetylation defects are correlated with a decrease of the RNA polymerase II recruitment through the transcribed region of target genes, whereas the recruitment on the promoter is mostly unaffected. These results indicate that Elongator affects transcript elongation in vivo, but not the recruitment of the RNA polymerase II to the promoter. These very specific effects of IKAP/hELP1 depletion on histone acetylation and RNA polymerase II density across target genes are consistent with a direct effect of Elongator on transcriptional elongation in vivo and point to a function for Elongator in histone acetylation during transcript elongation. Résumé: Caractérisation des rôles biologiques de la protéine IKAP et du complexe Elongator La transcription des gènes de lADN en ARN est fondamentale pour lexpression des protéines et la capacité de nos cellules à sadapter à leur environnement. Ce processus finement régulé est catalysé par un enzyme, lARN polymérase II, vers lequel convergent une multitude de voies de signalisation. Dans le cadre de ce travail, nous nous sommes intéressés aux fonctions moléculaires et cellulaires de la protéine IKAP et du complexe Elongator. IKAP est la protéine qui assemble les sous unités dElongator en un complexe fonctionnel. Le complexe Elongator est associé à lARN polymérase II hyper-phosphorylée pendant létape délongation de la transcription et possède une activité histone acétyltransferase associée à une de ses sous unités, appelée ELP3. Chez la levure, Elongator est recruté an niveau des ARNs naissants, qui émanent directement de lARN polymérase II au niveau de la région transcrite des gènes étudiés. De plus, des expériences dimmunoprécipitation de la chromatine ont mis en évidence la présence du complexe Elongator au niveau de plusieurs gènes humains. Différentes mutations au niveau du gène IKBKAP, codant pour la protéine IKAP, sont responsables de la dysautonomie familiale, une maladie génétique qui affecte le développement du système nerveux périphérique. En effet, les individus affectés présentent une diminution de la densité de neurones au niveau des ganglions nerveux périphériques. Lobjectif de nos travaux est de comprendre davantage le rôle de la protéine IKAP et du complexe Elongator dans la transcription des gènes et ainsi, dinvestiguer les mécanismes moléculaires responsables dans la physiopathologie de la dysautonomie familiale. Un modèle de perte de fonction pour la protéine IKAP a dabord été généré par interférence dARN. Des travaux réalisés chez la levure indiquent que la protéine ELP1 (homologue de IKAP chez la levure) est essentielle pour la stabilité de la sous unité catalytique du complexe, la protéine ELP3. Les expériences réalisées sur notre modèle humain démontrent que le taux de la protéine ELP3 est également affecté par la déplétion dIKAP causée par linterférence dARN. Ce modèle de perte de fonction a été utilisé afin détablir la liste des gènes dont lexpression est contrôlée par la protéine IKAP, par des expériences de microarrays. Parmi les candidats identifiés, plusieurs ont été décrits comme impliqués dans la migration cellulaire et le remodelage du cytosquelette dactine. Le processus de migration des cellules est fondamental au cours du développement du système nerveux et par conséquent particulièrement relevant dans le contexte de la dysautonomie familiale. Limplication dIKAP dans la migration cellulaire a été investigué par différents tests de fonction qui montrent que la diminution dIKAP dans différentes lignées cellulaires entraîne une réduction significative de leur capacité migratoire. Ces résultats suggèrent que la diminution du nombre de neurones observée dans les ganglions périphériques des patients atteints de la dysautonomie familiale pourrait résulter dune altération de leur capacité à migrer au cours du développement. Enfin, des expériences dimmunoprécipitation de la chromatine ont été menées en utilisant notre modèle afin de déterminer dans quelle mesure le déficit de migration observé en labsence dIKAP serait la conséquence dun défaut de la fonction dElongator au niveau de lélongation de la transcription des gènes. Les résultats nous ont montré que la diminution dexpression dIKAP entraîne une réduction de lacétylation des histones H3 dans la région transcrite de ses gènes cibles. De plus, ce déficit dacétylation est directement corrélé avec un désengagement progressif de lARN polymérase II le long de la région transcrite de ces gènes. Par conséquent, ces résultats démontrent que le complexe Elongator affecte lélongation des transcrits in vivo, mais pas le recrutement de lARN polymérase II au niveau du promoteur. Ces effets très spécifiques de labsence dIKAP sur lacétylation des histones et lengagement de la polymérase II dans la transcription des gènes cibles montrent quElongator exerce un rôle direct au niveau de lélongation de la transcription de ces gènes. De plus, ces résultats suggèrent que la fonction dElongator serait dacétyler les histones au cours de lélongation transcriptionnelle in vivo.