Thesis (Ph. D.)--University of Texas Health Science Center at Houston, School of Public Health, 2007. / Includes bibliographical references (leaves 58-59).

Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xiii, 108 p.; also includes graphics. Includes bibliographical references (p. 104-108). Available online via OhioLINK's ETD Center

Thesis (Ph. D.)--Georgia State University, 2008. / Title from title page (Digital Archive@GSU, viewed July 20, 2010) Carolyn F. Furlow, committee chair; Philo A. Hutcheson, Phillip E. Gagne, Sheryl A. Gowen, committee members. Includes bibliographical references (p. 96-100).

Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xi, 106 p.; also includes graphics. Includes bibliographical references (p. 103-106). Available online via OhioLINK's ETD Center

Thesis (Ph.D.)--Baylor University, 2009. / Includes bibliographical references (p. 175-178).

M.Ing. (Electrical and Electronic Engineering) / Missing data is an issue which leads to a variety of problems in the analysis and processing of data in datasets in almost every aspect of day−to−day life. Due to this reason missing data and ways of handling this problem have been an area of research in a variety of disciplines in recent times. This thesis presents a method which is aimed at finding approximations to missing values in a dataset by making use of Genetic Algorithm (GA), Simulated Annealing (SA), Particle Swarm Optimization (PSO), Random Forest (RF), Negative Selection (NS) in combination with auto-associative neural networks, and also provides a comparative analysis of these algorithms. The methods suggested use the optimization algorithms to minimize an error function derived from training an auto-associative neural network during which the interrelationships between the inputs and the outputs are obtained and stored in the weights connecting the different layers of the network. The error function is expressed as the square of the difference between the actual observations and predicted values from an auto-associative neural network. In the event of missing data, all the values of the actual observations are not known hence, the error function is decomposed to depend on the known and unknown variable values. Multi Layer Perceptron (MLP) neural network is employed to train the neural networks using the Scaled Conjugate Gradient (SCG) method. The research primarily focusses on predicting missing data entries from two datasets being the Manufacturing dataset and the Forest Fire dataset. Prediction is a representation of how things will occur in the future based on past occurrences and experiences. The research also focuses on investigating the use of this proposed technique in approximating and classifying missing data with great accuracy from five classification datasets being the Australian Credit, German Credit, Japanese Credit, Heart Disease and Car Evaluation datasets. It also investigates the impact of using different neural network architectures in training the neural network and finding approximations for the missing values, and using the best possible architecture for evaluation purposes. It is revealed in this research that the approximated values for the missing data obtained by applying the proposed models are accurate with a high percentage of correlation between the actual missing values and corresponding approximated values using the proposed models on the Manufacturing dataset ranging between 94.7% and 95.2% with the exception of the Negative Selection algorithm which resulted in a 49.6% correlation coefficient value. On the Forest Fire dataset, it was observed that there was a low percentage correlation between the actual missing values and the corresponding approximated values in the range 0.95% to 4.49% due to the nature of the values of the variables in the dataset. The Negative Selection algorithm on this dataset revealed a negative percentage correlation between the actual values and the approximated values with a value of 100%. Approximations found for missing data are also observed to depend on the particular neural network architecture employed in training the dataset. Further analysis revealed that the Random Forest algorithm on average performed better than the GA, SA, PSO, and NS algorithms yielding the lowest Mean Square Error, Root Mean Square Error, and Mean Absolute Error values. On the other end of the scale was the NS algorithm which produced the highest values for the three error metrics bearing in mind that for these, the lower the values, the better the performance, and vice versa. The evaluation of the algorithms on the classification datasets revealed that the most accurate in classifying and identifying to which of a set of categories a new observation belonged on the basis of the training set of data is the Random Forest algorithm, which yielded the highest AUC percentage values on all of the five classification datasets. The differences between its AUC values and those of the GA, SA, PSO, and NS algorithms were statistically significant, with the most statistically significant differences observed when the AUC values for the Random Forest algorithm were compared to those of the Negative Selection algorithm on all five classification datasets. The GA, SA, and PSO algorithms produced AUC values which when compared against each other on all five classification datasets were not very different. Overall analysis on the datasets considered revealed that the algorithm which performed best in solving both the prediction and classification problems was the Random Forest algorithm as seen by the results obtained. The algorithm on the other end of the scale after comparisons of results was the Negative Selection algorithm which produced the highest error metric values for the prediction problems and the lowest AUC values for the classification problems.

Since the discovery of AIDS among the gay men in 1981 in the United States of America, it has become a major world pandemic with over 40 million individuals infected world wide. According to the Joint United Nations Programme against HIV/AIDS epidermic updates in 2012, 28.3 million individuals are living with HIV world wide, 23.5 million among them coming from sub-saharan Africa and 4.8 million individuals residing in Asia. The report showed that approximately 1.7 million individuals have died from AIDS related deaths, 34 million ± 50% know their HIV status, a total of 2:5 million individuals are newly infected, 14:8 million individuals are eligible for HIV treatment and only 8 million are on HIV treatment (Joint United Nations Programme on HIV/AIDS and health sector progress towards universal access: progress report, 2011). Numerous studies have been carried out to understand the pathogenesis and the dynamics of this deadly disease (AIDS) but, still its pathogenesis is poorly understood. More understanding of the disease is still needed so as to reduce the rate of its acquisition. Researchers have come up with statistical and mathematical models which help in understanding and predicting the progression of the disease better so as to find ways in which its acquisition can be prevented and controlled. Previous studies on HIV/AIDS have shown that, inter-individual variability plays an important role in susceptibility to HIV-1 infection, its transmission, progression and even response to antiviral therapy. Certain immuno-genetic factors (human leukocyte antigen (HLA), Interleukin-10 (IL-10) and single nucleotide polymorphisms (SNPs)) have been associated with the variability among individuals. In this dissertation we are going to reaffirm previous studies through statistical modelling and analysis that have shown that, immuno-genetic factors could play a role in susceptibility, transmission, progression and even response to antiviral therapy. This will be done using the Sinikithemba study data from the HIV Pathogenesis Programme (HPP) at Nelson Mandela Medical school, University of Kwazulu-Natal consisting of 451 HIV positive and treatment naive individuals to model how the HIV Bio-markers (viral load and CD4 count) are associated with the immuno-genetic factors using linear mixed models. We finalize the dissertation by dealing with drop-out which is a pervasive problem in longitudinal studies, regardless of how well they are designed and executed. We demonstrate the application and performance of multiple imputation (MI) in handling drop-out using a longitudinal count data from the Sinikithemba study with log viral load as the response. Our aim is to investigate the influence of drop-out on the evolution of HIV Bio-markers in a model including selected genetic factors as covariates, assuming the missing mechanism is missing at random (MAR). We later compare the results obtained from the MI method to those obtained from the incomplete dataset. From the results, we can clearly see that there is much difference in the findings obtained from the two analysis. Therefore, there is need to account for drop-out since it can lead to biased results if not accounted for. / Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2013.

Indiana University-Purdue University Indianapolis (IUPUI) / Linking the new institutionalism to entrepreneurial orientation (EO), my dissertation investigates institutional forces and entrepreneurial forces—two contradicting types of forces—as main effects and moderating effects upon practices and performance of organizations embedded in the institutional duality. The case chosen observes unique hybrid funders that this study collectively calls social investment funders (SIF), which integrate philanthropy and venture capital investment to create and implement a venture philanthropy model for a pursuit of their mission. A theoretical framework is developed to propose regulative and normative pressures from two dominant institutions governing SIFs. Original data collected from 146 organizations are scrutinized by moderated multiple regressions for two empirical studies: Study 1 for effects on SIFs’ venture philanthropy practices, and Study 2 for effects on SIFs’ social and financial performance. Multiple imputations, diagnostic analyses, and several post hoc analyses are also conducted for robustness of data and results from multiple regression analyses. Results from these analyses find that EO and venture capital institutional forces both enhance SIFs’ venture philanthropy practices. A hypothesis postulated for a negative relationship between the nonprofit status and venture philanthropy practices is also supported. Results from moderated regression analyses, along with a subgroup and EO subdimension analyses, confirm a moderating effect between EO and the nonprofit status, i.e., a regulative institutional pressure. A positive relationship is found in EO- financial performance, but not in EO-social performance. While support is lent to hypotheses posited for a social/financial performance relationship with donors’/investors’ demand for social outcomes, and with the management team’s training in business, the overall results remain mixed for Study 2. Nonetheless, this dissertation appears to be the first study to theorize and test EO as a micro-level condition enabling organizations to strategically shape and resist institutional pressures, and it reinforces that organizations’ behavior is not merely a product of their passive conformity to environmental forces, but of the agency, also. As such, this study aims to contribute to scholarly efforts by the “agency camp” of the new institutionalism and EO, answering a call from the leading scholars of both EO (Miller) and the new institutionalism (Oliver).