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Chronic autoimmune arthritis in rats pathogenesis and genetic factors /Vingsbo Lundberg, Carina. January 1997 (has links)
Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted. Includes bibliographical references.
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Treatment of experimental hemorrhagic and burn shock with 1-ethanesulfonyl-4-ethyl piperazineJordan, Steven Ernest, January 1954 (has links)
Thesis (Ph. D.)--University of Wisconsin, 1954. / Typescript (carbon copy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 78-85).
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Animal models of Chlamydia pneumoniae and atherosclerosis : dissemination to and persistence in atheromatous lesions /Moazed, Teresa Clark. January 1996 (has links)
Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [83]-96).
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Modulation of glutathione associated with methylmercury exposure in mice /Thompson, Sally A. January 1996 (has links)
Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [116]-124).
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Chronic autoimmune arthritis in rats pathogenesis and genetic factors /Vingsbo Lundberg, Carina. January 1997 (has links)
Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted. Includes bibliographical references.
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Development of an animal model for tumor xenotransplantationHoogenhout, Jacob, January 1982 (has links)
Thesis (doctoral)--Nijmegen, 1982.
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Effects of treprostinil sodium in a monocrotaline-induced rat model of pulmonary hypertensionLatcham, Shena L., January 2005 (has links)
Thesis (M.S.)--University of Missouri-Columbia, 2005. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2005" Includes bibliographical references.
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Effects of ischemic metabolites and chronic exercise on cardiac myocyte functionHinken, Aaron C., January 2005 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2005. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May, 2005" Includes bibliographical references.
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Incorporating model selection and decision analysis into population dynamics modeling /Ward, Eric John, January 2006 (has links)
Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 127-139).
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Efeito de uma membrana de PCL impregnada com hidroxiapatita em defeito ósseo induzido na calvária de ratos / The effect of a PCL membrane impregnated with hydroxyapatite in bone healing defect induced in rat calvariaGroppo, Mônica Feresini, 1965- 08 November 2014 (has links)
Orientador: Ana Cláudia Rossi / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-26T07:37:41Z (GMT). No. of bitstreams: 1
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Previous issue date: 2014 / Resumo: O objetivo do presente estudo foi observar o efeito de uma membrana de nanofibras poliméricas a base de poli-epsilon-caprolactona (PCL), impregnadas ou não com hidroxiapatita (HA), na reparação óssea em defeitos críticos produzidos artificialmente na calvária de ratos. Foram utilizados 36 ratos, divididos aleatoriamente em seis grupos de seis animais. Para a indução do defeito ósseo padronizado foram realizadas duas perfurações, por meio de trefina de 3 mm de diâmetro, na calvária dos animais, uma em cada lado, sendo que o lado direito recebeu os tratamentos (HA ou PCL-HA) e os controles (coágulo ou PCL) foram feitos no lado esquerdo. Decorridos 30, 60 e 90 dias da cirurgia, os animais foram mortos por aprofundamento da anestesia. As cabeças foram submetidas à tomografia, considerando um voxel de 0.12 mm, com campo visual de 06 × 16 cm e tempo de aquisição de 40s. Foram utilizados 120 kV, 8 mA e 36.12 mA/s na aquisição. Os diâmetros dos orifícios foram medidos por meio do software Invesalius 3.0. As cabeças foram fixadas com solução de formol tamponado (pH 7,2) em tampão fosfato de sódio a 0,1 M, durante 72 horas e submetidas à descalcificação em solução de EDTA a 7% e formol a 5% até verificação de completa descalcificação (aproximadamente 30 dias). Cortes semi-seriados de 7 ?m foram corados por Hematoxilina-Eosina e foram observadas as características histológicas do processo de cicatrização óssea nas lâminas nos diferentes tempos do estudo. A comparação quantitativa das medidas dos orifícios obtidas com a tomografia foi feita pelo teste de Kruskal-Wallis (teste de Dunn como post hoc), considerando um nível de significância de 5%. As imagens tomográficas revelaram uma tendência de redução do volume do orifício ao longo do tempo, a qual foi maior após 90 dias para todos os tratamentos. O tratamento com PCL+HA mostrou menor volume de orifício do que os outros tratamentos independentemente do período. As medidas histológicas mostraram maior formação de osso induzida pela membrana de PCL com ou sem HA do que os outros tratamentos independentemente do período. A HA mostrou maior aumento da cicatrização óssea com ou sem o PCL. Concluímos que a HA adicionada às nanofibras de PCL melhorou significativamente a cicatrização óssea em defeitos provocados na calvária de ratos / Abstract: The aim of the present study was to observe the effect of a polymeric-nanofiber membrane of poly-epsilon-caprolactone (PCL) with or without hydroxyapatite (HA) on bone healing of critical defects induced in rat calvaria. 36 animals were randomly divided into six groups. The standardized bone defects were obtained by two perforations with 3.0 mm diameter trephine directly into the animals¿ calvaria, one in each side. The right side received the treatments (HA or PCL-HA) and the left side the controls (blood clot or PCL). After 30, 60 and 90 days of the surgical procedure, all animals were killed; the head was sectioned and submitted to tomography (voxel of 0.12 mm, visual field of 6x16 cm, acquisition time of 40s, 120 kV, 8mA and 36.12 mA/s). The perforation diameters were measured using the software Invesalius 3.0. After tomography, all heads were fixed by buffered formol (pH=7.2) in 0.1M sodium-phosphate buffer during 72 hours and submitted to decalcification in 7% EDTA/5% formol solution until complete decalcification (approximately 30 days). Semi-serial 7 µm cuts were stained with Hematoxicilin-Eosin. Histological characteristics of bone healing were observed according to groups and periods. Quantitative comparisons of perforation measurements from both tomography and histological analysis were performed by Kruskal-Wallis (Dunn post hoc) test with a 5% significance level. Tomography images revealed a tendency to reduce the perforation volume along time, which was higher after 90 days for all treatments. The treatment with PCL+HA showed the lower volumes of perforations than the other treatments irrespectively of the period. Histological measurements showed more osseous formation induced by treatment with PCL with or without HA than the other treatments irrespectively of the period. HA appear to increase bone healing with or without PCL. We concluded that HA added to PCL nanofibers significantly improved the bone healing in bone defects of rat calvaria / Mestrado / Anatomia / Mestra em Biologia Buco-Dental
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