In this thesis, we present a new low-complexity receiver with the modified hybrid signature direct-sequence code division multiple access (DS-CDMA) system framework that use the multiple-input multiple-output (MIMO) antennas along with Alamouti¡¦s space-time block code (ST-BC). In the transceiver, the modified hybrid signature is exploited. It is not only used to counteract the inter-symbol interference (ISI) introduced by the channel fading duo to multipath propagation but also very useful for extracting the full channel information in the receiver. For reducing computational complexity, we propose a new modified partial adaptivity (MPA) filter. It is not only having the advantage of subspace-based PA-GSC filter to enhance the system performance but also avoid the computation requirement when the Eigen-decomposition approach was adopted. Next, with the modified transceiver framework, in the receiver, based on the linearly constrained constant modulus (LCCM) criterion, we propose a novel semi-blind multiple detector schemes for MIMO-CDMA systems, which is implementing with the adaptive RLS algorithm and framework in the modified partially adaptive (MPA) generalized sidelobe canceller (GSC) . Our proposed scheme is able to perform the two-branch filterbank of LCCM MIMO-CDMA receiver. Computer simulations demonstrate that the proposed receiver has better performance than the convention CM-GSC-RLS receiver with much lower computational load.