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Cloning and characterization of novel IgA antibody variable heavy and light chains from HIV-1 resistant sex workers from Nairobi, KenyaSarna, Caitlin S. 14 April 2011 (has links)
Heterosexual intercourse now accounts for the majority of HIV transmission
within sub-Saharan Africa. The generation of microbicides and vaccines, therefore, requires a better understanding of the mucosal correlates of protection, including the role of HIV-specific IgA.
It is now accepted that not all individuals are equally susceptible to HIV-1 infection, as exemplified by the HIV Exposed Seronegative (HESN) women of the Pumwani Cohort in Nairobi, Kenya. To assess whether mucosal IgA responses contribute to this protection, 3 novel IgA variable genes were cloned from HESN cervical B-cell cDNA.
Nine monoclonal IgA Abs were produced, two of which were properly produced
from cell culture. The HESN-derived A6/30L and A9/30L variants had a greater specificity for gp120IIIB than their A6/4L and A9/4L counterparts, while the A6 variant recognizes a distinct gp120 epitope compared to the broadly neutralizing antibody IgGb12. Further characterization of these IgA chains may suggest their suitability for use in microbicides or mucosal vaccines.
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Immunosuppression with monoclonal antibodies in neural transplantationHoney, C. R. January 1990 (has links)
No description available.
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Studies on the functional heterogeneity of rat T cells using monoclonal antibodiesSpickett, Gavin January 1983 (has links)
No description available.
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Engineered Antibodies. Production and application of chimeric and single-chain antibodies as positive controls in the diagnosis of infectious diseases by ELISA.Jones, Martina Unknown Date (has links)
No description available.
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Analysis of acute mycloid leukaemia cell surface antigens with monoclonal antibodies /Gadd, Stephen J. January 1985 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, 1985. / Includes bibliographical references (leaves 129-145).
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Studies of the hepatitis C virus envelope proteins : interaction with host cells and as targets for the humoral response /Beyene, Aster, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
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Characterization of an acanthamoeba castellanii adhesinKennett, Mary J. January 1999 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 1999. / Typescript. Vita. Includes bibliographical references (leaves 117-128). Also available on the Internet.
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Site-directed in vitro immunization a model of sequential antigen-specific activation of human B cells /Chin, Li-Te. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.
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Mass transfer, mixing, Chinese hamster ovary cell growth and antibody production characterization using Rushton turbine and marine impellarsSandadi, Sandeep. January 2009 (has links)
Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Chemical and Biochemical Engineering." Includes bibliographical references (p. 113-118).
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Characterization of a monoclonal antibody reactive against major histocompatibility complex class II antigens /Yip, Tak-chun, Timothy. January 1992 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1993. / Cover title.
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