The automotive safety company Veoneer are producers of high end driver visual assistance systems, but the knowledge about the absolute accuracy of their dynamic calibration algorithms that estimate the vehicle’s orientation is limited. In this thesis, a novel measurement system is proposed to be used in gathering reference data of a vehicle’s orientation as it is in motion, more specifically the pitch and roll angle of the vehicle. Focus has been to estimate how the uncertainty of the measurement system is affected by errors introduced during its construction, and to evaluate its potential in being a viable tool in gathering reference data for algorithm performance evaluation. The system consisted of three laser distance sensors mounted on the body of the vehicle, and a range of data acquisition sequences with different perturbations were performed by driving along a stretch of road in Linköping with weights loaded in the vehicle. The reference data were compared to camera system data where the bias of the calculated angles were estimated, along with the dynamic behaviour of the camera system algorithms. The experimental results showed that the accuracy of the system exceeded 0.1 degrees for both pitch and roll, but no conclusions about the bias of the algorithms could be drawn as there were systematic errors present in the measurements. / Bilsäkerhetsföretaget Veoneer är utvecklare av avancerade kamerasystem inom förarassistans, men kunskapen om den absoluta noggrannheten i deras dynamiska kalibreringsalgoritmer som skattar fordonets orientering är begränsad. I denna avhandling utvecklas och testas ett nytt mätsystem för att samla in referensdata av ett fordons orientering när det är i rörelse, mer specifikt dess pitchvinkel och rollvinkel. Fokus har legat på att skatta hur osäkerheten i mätsystemet påverkas av fel som introducerats vid dess konstruktion, samt att utreda dess potential när det kommer till att vara ett gångbart alternativ för att samla in referensdata för evaluering av prestandan hos algoritmerna. Systemet bestod av tre laseravståndssensorer monterade på fordonets kaross. En rad mätförsök utfördes med olika störningar introducerade genom att köra längs en vägsträcka i Linköping med vikter lastade i fordonet. Det insamlade referensdatat jämfördes med data från kamerasystemet där bias hos de framräknade vinklarna skattades, samt att de dynamiska egenskaperna kamerasystemets algoritmer utvärderades. Resultaten från mätförsöken visade på att noggrannheten i mätsystemet översteg 0.1 grader för både pitchvinklarna och rollvinklarna, men några slutsatser kring eventuell bias hos algoritmerna kunde ej dras då systematiska fel uppstått i mätresultaten.

Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro / Nessa tese foi feito um estudo preliminar, destinado à elaboração do programa experimental inicial para a primeira instalação da tomografia com prótons (pCT) brasileira por meio de modelagem computacional. A terapia com feixe de prótons é uma forma bastante precisa de tratamento de câncer. Atualmente, o planejamento de tratamento é baseado na tomografia computadorizada com raios X, alternativamente, a tomografia com prótons pode ser usada. Algumas questões importantes, como efeito de escala e a Curva de Calibração (fonte de dados iniciais para planejamento de terapia com prótons), foram estudados neste trabalho. A passagem de prótons com energias iniciais de 19,68MeV; 23MeV; 25MeV; 49,10MeV e 230MeV pelas camadas de materiais variados (água, alumínio, polietileno, ouro) foi simulada usando códigos Monte Carlo populares como SRIM e GEANT4. Os resultados das simulações foram comparados com a previsão teórica (baseada na solução aproximada da equação de transporte de Boltzmann) e com resultados das simulações feitas com outro popular código Monte Carlo MCNPX. Análise comparativa dos resultados das simulações com dados experimentais publicados na literatura científica para alvos grossos e na faixa de energias de prótons usada em medidas em pCT foi feita. Foi observado que apesar de que todos os códigos mostram os resultados parecidos alguns deslocamentos não sistemáticos podem ser observados. Foram feitas observações importantes sobre a precisão dos códigos e uma necessidade em medidas sistemáticas de frenagem de prótons em alvos grossos foi declarada. / In the present work a preliminary research via computer simulations was made in order to elaborate a prior program for the first experimental pCT setup in Brazil. Proton therapy is a high precise form of a cancer treatment. Treatment planning nowadays is performed basing on X ray Computer Tomography data (CT), alternatively the same procedure could be performed using proton Computer Tomography (pCT). Some important questions, as a scale effect and so called Calibration Curve (as a source of primary data for pCT treatment planning) were studied in this work. The 19.68MeV; 23MeV; 25MeV; 49.10MeV e 230MeV protons passage through varied absorbers (water, aluminum, polyethylene, gold) were simulated by such popular Monte Carlo packages as SRIM and GEANT4. The simulation results were compared with a theoretic prevision based on approximate solution of the Boltzmann transport equation and with simulation results of the other popular Monte Carlo code MCNPX. The comparative analysis of the simulations results with the experimental data published in scientific literature for thick absorbers and within the energy range used in the pCT measurements was made. It was noted in spite of the fact that all codes showed similar results some nonsystematic displacements can be observed. Some important observations about the codes precision were made and a necessity of the systematic measurements of the proton stopping power in thick absorbers was declared.

Monte Carlo simulation techniques have emerged as widely accepted computing tools in tackling many problems in modern structural mechanics. Apart from developments in computational hardware, which have undoubtedly made simulation strategies practically feasible, the success of Monte Carlo simulations has also resulted equally significantly from the methodological developments aimed at controlling sampling variance of the Monte Carlo estimates. The study reported in the present thesis is aimed at developing and validating Monte Carlo simulation based approaches with inbuilt variance reduction capabilities to deal with problems of time variant reliability modeling, random vibration testing, and updating reliability models for statically/dynamically loaded instrumented structures. The relevant literature has been reviewed in Chapter 1. Time variant reliability analysis of randomly parametered and randomly driven non-linear vibrating systems has been tackled by combining two Monte Carlo variance reduction strategies into a single framework (Chapter 2). The first of these strategies is based on the application of the Girsanov transformation to account for the randomness in dynamic excitations and, the second approach is fashioned after the subset simulation method to deal with randomness in system parameters. A novel experimental test procedure to estimate the reliability of structural dynamical systems under excitations specified via random process models has been proposed (Chapter 3). The samples of random excitations to be used in the test are modified by the addition of an artificial control force. An unbiased estimator for the reliability is derived based on measured ensemble of responses under these modified inputs based on the tenets of Girsanov’s transformation. The study observes that an acceptable choice for the control force (that can reduce the sampling variance of the estimator) can be made solely based on experimental techniques. This permits the proposed procedure to be applied in the experimental study of time variant reliability of complex structural systems which are difficult to model mathematically. Illustrative example consists of a multi-axes shake table study on bending-torsion coupled, geometrically non-linear, five-storey frame under uni/bi-axial, non-stationary, random base excitation. The first order reliability method (FORM) and inverse FORM have been extended to handle the problem of updating reliability models for existing, statically loaded structures based on measured responses (Chapter 4). The proposed procedures are implemented by combining Matlab based reliability modules with finite element models residing on the Abaqus software. Numerical illustrations on linear and non-linear frames are presented. A solution strategy within the framework of Monte Carlo simulation based dynamic state estimation method and Girsanov’s transformation for variance reduction has been developed to tackle the problem of updating the reliability of instrumented structures based on measured response under random dynamic loading (Chapter 5). For linear Gaussian state space models, the solution is developed based on continuous version of the Kalman filter, while, for non-linear and (or) non-Gaussian state space models, bootstrap particle filters are adopted. Results from laboratory testing of an archetypal five storey bending-torsion coupled frame under seismic base motions form the basis of one of the illustrative examples. A set of three annexures contain details of numerical methods for discretizing Ito’s differential equations (Annexure 1), working of the Girsanov transformation through Kolmogorov’s equations (Annexure 2) and tools for interfacing Matlab and Abaqus codes (Annexure 3).

Estudamos o diagrama de fases e o ponto tricrítico da transição de colapso em um modelo de animais na rede quadrada, a partir da expansão em série da compressibilidade isotérmica KT do sistema. Como função das variáveis x (fugacidade) e y = e1/T (T é a temperatura reduzida), a serie KT é analisada utilizando-se a técnica dos aproximantes diferenciais parciais. Determinamos o padrão de fluxo das trajetórias características de um típico aproximante diferencial parcial com ponto fixo estável. Obtemos estimativas satisfatórias para a fugacidade tricrítica Xt = 0.024 &#177 0.005 e a temperatura tricritica Tt = 0.54 &#177 0.04. Considerando somente campos de escala lineares, obtemos também o expoente de escala &#947 = 1.4 &#177 0.2 e o expoente \"crossover\" &#934 = 0.66 &#177 0.08. Nossos resultados estão em boa concordância com estimativas prévias obtidas por outros métodos. Também estudamos um processo de polimerização ramifIcada através de simulações computacionais na rede quadrada baseadas em um modelo de crescimento cinético generalizado para se incorporar ramifIcações e impurezas. A configuração do polímero e identificada com uma árvore-ligação (\"bond tree\") a fim de se examinar os aspectos topológicos. As dimensões fractais dos aglomerados (\"clusters\") são obtidas na criticalidade. As simulações também permitem o estudo da evolução temporal dos aglomerados bem como a determinação das auto-correlações temporais e expoentes críticos dinâmicos. Com relação aos efeitos de tamanho finito, uma técnica de cumulantes de quarta ordem e empregada para se estimar a probabilidade de ramificação critica bc e os expoentes críticos v e &#946. Na ausência de impurezas, a rugosidade da superfície e descrita em termos dos expoentes de Hurst. Finalmente, simulamos este modelo de crescimento cinético na rede quadrada utilizando um método de Monte Carlo para estudar a polimerização ramificada com interações atrativas de curto alcance entre os monômeros. O diagrama de fases que separa os regimes de crescimento finito e infinito e obtido no plano (T,b) (T é a temperatura reduzida e b é a probabilidade de ramificação). No limite termodinâmico, extrapolamos a temperatura T&#8727 = 0.102 &#177 0.005 abaixo da qual a fase e sempre infinita. Observamos também a ocorrência de uma transição de rugosidade na superfície do polímero. / The phase diagram and the tricritical point of a collapsing lattice animal are studied through an extended series expansion of the isothermal compressibility KT on a square lattice. As a function of the variables x (fugacity) and y = e1/T (T is the reduced temperature), this series KT is investigated using the partial differential approximants technique. The characteristic flow pattern of partial differential approximant trajectories is determined for a typical stable fixed point. We obtain satisfactory estimates for the tricritical fugacity Xt = 0.024 &#177 0.005and temperature Tt = 0.54 &#177 0.04.Taking into account only linear scaling fields we are also able to get the scaling exponent &#947 = 1.4 &#177 0.2 and the crossover exponent &#934 = 0.66 &#177 0.08. Our results are in good agreement with previous estimates from other methods. We also study ramified polymerization through computational simulations on the square lattice of a kinetic growth model generalized to incorporate branching and impurities. The polymer configuration is identified with a bond tree in order to examine its topology. The fractal dimensions of clusters are obtained at criticality. Simulations also allow the study of time evolution of clusters as well as the determination of time autocorrelations and dynamical critical exponents. In regard to finite size effects, a fourth-order cumulant technique is employed to estimate the critical branching probability be and the critical exponents v and &#946. In the absence of impurities, the surface roughness is described in terms of the Hurst exponents. Finally we simulate this kinetic growth model on the square lattice using a Monte Carlo approach in order to study ramified polymerization with short distance attractive interactions between monomers. The phase boundary separating finite from infinite growth regimes is obtained in the (T,b) space (T is the reduced temperature and b is the branching probability). In the thermodynamic limit, we extrapolate the temperature T = 0.102 &#177 0.005 below which the phase is found to be always infinite. We also observe the occurrence of a roughening transition at the polymer surface.

L'hadronthérapie est une modalité de radiothérapie innovante dans laquelle des ions légers -tels des protons ou des ions carbone- sont accélérés à une vitesse relativiste, puis focalisés afin d'irradier la zone tumorale du patient. Cette technique se démarque de la radiothérapie dite conventionnelle utilisant des photons- par l'existence d'un pic de dépôt d'énergie, appelé pic de Bragg, qui se situe à la fin du parcours des ions. L'existence de différents phénomènes qui aboutissent à une incertitude sur le parcours des ions représente toutefois une limite à la précision intrinsèque de cette modalité. Cela justifie la nécessité d'une assurance qualité des traitements et motive le développement de techniques de suivi en ligne et en temps réel du parcours des ions. Ces travaux de thèse ont pour objet la caractérisation d'une technique de suivi du parcours des ions, appelée imagerie des vertex d'interaction. Il a en effet été observé que lors du parcours des ions dans le patient, une fraction importante de ceux-ci subit des réactions nucléaires, à l'origine d'un rayonnement de particules promptes secondaires chargées. Un télescope constitué de capteurs pixélisés est proposé pour localiser les vertex d'interaction de ces particules et mesurer leur corrélation avec le parcours des ions, corrélation prédite par des travaux in-silico précédents. La réalisation de plusieurs expériences durant lesquelles des cibles homogènes et hétérogènes ont été irradiées dans des conditions réalistes a permis d'obtenir les premiers résultats expérimentaux relatifs à cette technique, confrontés à des simulations qui ont également été réalisées. Avant de discuter l'ensemble des résultats obtenus, ce manuscrit détaille les aspects matériels et logiciels des importants développements mis en oeuvre et qui ont abouti à un prototype complet et fonctionnel d'imageur, accompagné de simulations Monte Carlo basées sur le logiciel Geant4 / Hadrontherapy is an innovative radiotherapy modality in which light ions -such as protons or carbon ionsare accelerated to a relativistic speed and focused to irradiate a tumoral area. This technique differs from the conventional radiotherapy -which uses photons- by the existence of an energy deposition peak, called Bragg peak, which stands at the end of the ions path. However, different phenomena that lead to uncertainty in the real ion range exist, and limit the intrinsic accuracy of this modality. This justifies the need for a treatments quality assurance and motivates the development of in-line and real-time monitoring techniques to follow the real ions range. This PhD thesis work aims the characterization of an ion range monitoring technic, called interaction vertex imaging. It has been observed that during the ion path in the patient, a significant part of incoming ions undergoes nuclear reactions, causing a prompt secondary charged particles radiation. A telescope made up of pixelated sensors is proposed to locate these particles interaction vertex and to measure their correlation with the ions range, correlation predicted by a previous in-silico work. The first experimental results for this technique has been obtained with the realization of several experiments during which homogeneous and heterogeneous targets were irradiated under realistic conditions. Simulations were also performed to compare with experimental results. Before discussing the overall results, this manuscript details the hardware and software aspects of important developments that was made and that resulted in a complete and working prototype imager, with Monte Carlo simulations based on the Geant4 software

L’objectif de cette thèse est l’étude d’un schéma numérique pour l’approximation des solutions d’équations différentielles doublement stochastiques rétrogrades (EDDSR). Durant les deux dernières décennies, plusieurs méthodes ont été proposées afin de permettre la résolution numérique des équations différentielles stochastiques rétrogrades standards. Dans cette thèse, on propose une extension de l’une de ces méthodes au cas doublement stochastique. Notre méthode numérique nous permet d’attaquer une large gamme d’équations aux dérivées partielles stochastiques (EDPS) nonlinéaires. Ceci est possible par le biais de leur représentation probabiliste en termes d’EDDSRs. Dans la dernière partie, nous étudions une nouvelle méthode des particules dans le cadre des études de protection en neutroniques. / The purpose of this thesis is to study a numerical method for backward doubly stochastic differential equations (BDSDEs in short). In the last two decades, several methods were proposed to approximate solutions of standard backward stochastic differential equations. In this thesis, we propose an extension of one of these methods to the doubly stochastic framework. Our numerical method allows us to tackle a large class of nonlinear stochastic partial differential equations (SPDEs in short), thanks to their probabilistic interpretation. In the last part, we study a new particle method in the context of shielding studies.

Functional magnetic resonance imaging (fMRI) is recent important method, used in neuroimaging. The aim of this thesis is to develop software tool for comparison of two methods for functional and effective connectivity estimation. In this thesis are described the basics of magnetic resonance imaging, fMRI, basic terms of fMRI experiments and generally are described methods of functional and effective connectivity. Then are more detailed mentioned methods of dynamic causal modeling (DCM), Granger causal modeling (GCM) and independent component analysis (ICA). Practical implementation of DCM in toolbox SMP and ICA in toolbox GIFT is also mentioned. In purpose to describe behavior of DCM and GCM in dependence on several parameters are performed Monte Carlo simulations. Then the concept and realization of software tool for simulating connectivity and comparison of DCM and GCM are described. Finally results of DCM and GCM comparison and results of Monte Carlo simulations are discussed.

<p>U ovoj disertaciji su prikazani rezultati kompleksnih istraživanja uticaja<br />kosmičkog zračenja na nuklearne spektre na nivou mora.<br />Utvrđivanje specifičnih vremenskih intervala u vremenskom spektru,<br />kojima odgovaraju tačno određene grupe događaja indukovane<br />kosmičkim mionima, omogućava adekvatno odbacivanje ometajućih<br />događaja u željenim energetskim oblastima detektovanih spektara, pri<br />antikoincidentnom režimu rada ultraniskofonskih sistema. U prvom<br />eksperimentu prikazanom u ovoj disertaciji,&nbsp; istraživana je mogućnost<br />vremenskog razlaganja detektovanih događaja,&nbsp; pomoću koincidentnog<br />sistema u čijem sklopu se nalazi HPGe detektor i&nbsp; plastični scintilator, u<br />povr&scaron;inskoj laboratoriji. Ustanovljeno je da se promptni i zakasneli<br />koincidentni događaji između plastičnog &ldquo;veto&rdquo; detektora i<br />germanijumskog detektora mogu jasno razdvojiti u dve grupe, za oko<br />100 ns. Dodatno, zakočno zračenje i&nbsp; anihilacioni događaji mogu se<br />razdvojiti u vremenu od (n,n&rsquo;) događaja, iako svi ovi događaji pripadaju<br />grupi zakasnelih događaja. Takođe, registrovani su&nbsp; i&nbsp; značajno zakasneli<br />anihilacioni događaji, koji nastaju usled raspada zaustavljenih pozitivnih<br />miona.<br />Drugi eksperiment prikazan u ovoj disertaciji baziran je na ultra-niskofonskom HPGe spektrometru relativne efikasnosti 100%.<br />Dodatkom dva plastična scintilatora i brzo-sporog koincidentnog kola,<br />istraživani su koincidentni događaji između plastičnih scintilatora i<br />HPGe spektrometra. Ovaj spektrometarski sistem MIREDO <em>(Muon<br />Induced Rare Event Dynamic Observatory</em>) prvenstveno je namenjen<br />proučavanju procesa indukovanih kosmičkim mionima u različitim<br />materijalima. Analiza ovakvih interakcija može biti od značaja za ultra-niskofonske eksperimente. Rezultati dobijeni za tri ispitivana materijala,<br />pakovana u<em> Marinelli</em> sud, prezentovani su i diskutovani.<br />U trećem eksperimentu prikazanom u ovoj disertaciji ispitan je<br />potencijalni uticaj solarnih&nbsp; neutrina&nbsp; na izmerenu brzinu&nbsp; radioaktivnog<br />raspada,&nbsp; merenjem varijacija u brzini brojanja<br />³H&nbsp; metodom tečnog&nbsp;scintilacionog brojanja. Kori&scaron;ćenjem sofisticiranog tečnog scintilacionog&nbsp;spektrometra&nbsp;<em> Quantulus</em>&nbsp; ustanovljeno je da na merenje<br />visokoenergetskog dela&nbsp;³H spektra može značajno uticati nestabilnost<br />instrumenta. Oscilatorni karakter izmerenog visokoenergetskog dela<br />³H&nbsp;spektra&nbsp; je registrovan, ali sa veoma malom amplitudom (manjom od<br />0.5%), koja se ne može jednostavno objasniti samo nestabilno&scaron;ću<br />instrumenta.&nbsp; Kada je meren ukupan&nbsp;³H spektar, nisu nađene značajne<br />varijacije u brzini brojanja.<br />Već duže vreme je poznato da je niskoenergetsko gama zračenje<br />kontinualne distribucije prisutno na otvorenom prostoru, u vazduhu na<br />povr&scaron;ini Zemlje. U prethodnim istraživanjima pretpostavljano je da&nbsp; ovo<br />zračenje potiče skoro isključivo od gama fotona koji su emitovani usled<br />prirodne radioaktivnosti i potom rasejani u nazad od strane vazduha<br />iznad zemlje. U četvrtom eksperimentu prikazanom u ovoj disertaciji<br />pokazano je da&nbsp; je&nbsp; ovo zračenje (u energetskom regionu 30 keV-300<br />keV), sa maksimumom na oko&nbsp; 90 keV, u značajnoj meri&nbsp; proizvedeno<br />kosmičkim zračenjem, sa fluksom fotona od oko 3000 m^-2s^-1. Takođe,<br />ustanovljeno je da dozama op&scaron;te populacije doprinosi ovo sveprisutno<br />niskoenergetsko gama zračenja kosmičkog porekla, zajedno sa<br />odgovarajućim fluksom niskoenergetskih elektrona i da ove komponente<br />ukupnih doza indukovanih kosmičkim zračenjem na nivou mora nisu<br />zanemarljive.</p> / <p>In this dissertation results of complex research on cosmic-ray impact on&nbsp;nuclear spectra at sea level are shown.&nbsp; The appropriate selection of&nbsp;coincidence time interval &nbsp;in low-background experiments that are based&nbsp;on the rejection of anticoincidence background events is very important&nbsp;for reducing the influence of cosmic-ray muons on acquired spectral&nbsp;data. In&nbsp; the first&nbsp; experiment&nbsp; presented in this dissertation,&nbsp; performed by&nbsp;the coincidence system of an HPGe detector and a plastic detect or&nbsp; in a&nbsp;surface laboratory, the time resolution of the detected events is explored.&nbsp;It is&nbsp; found that the prompt and delayed coincidence events between a&nbsp;plastic veto detector and a &nbsp;Ge detector can be sharply divided for&nbsp;approximately 100 ns in two groups. In addition, the bremsstrahlung&nbsp;and annihilation events can&nbsp; be time-resolved from the (n,n&rsquo;) events,&nbsp;although all of these events belong to the group of delayed events. Also,&nbsp;substantially delayed annihilation events, which are caused by the&nbsp;<br />decays of stopped positive muons, were detected.<br />The second experiment shown in this dissertation is based on the 100%&nbsp;relative efficiency ultra-low-background HPGe spectrometer. With the&nbsp;addition of two plastic scintillators and a fast-slow coincidence circuit,&nbsp;the coincidence events between the plastic detectors and the HPGe&nbsp;spectrometer have been investigated. This&nbsp; MIREDO (Muon Induced&nbsp;Rare Event Dynamic Observatory) spectrometer system is primarily&nbsp;<br />developed for the study of cosmic muon induced processes in different&nbsp;materials. Exploration of such interactions can be important for ultra-low&nbsp;background experiments. Results derived for three samples, placed in a&nbsp;Marinelli beaker, are presented and discussed.<br />In third experiment shown in this dissertation,&nbsp; the potential influence of&nbsp;solar neutrinos on measured decay rate is investigated by&nbsp; the liquid&nbsp;scintillation measurement of the count rate variations of&nbsp;³H. Making use of the sophisticated Quantulus liquid scintillation spectrometer, it is&nbsp;found that the&nbsp; measurement of the high-energy tail of&nbsp;³H spectrum may be significantly influenced by instrumental&nbsp; instability.&nbsp; The oscillatory behavior of measured high-energy tail of ³H spectrum&nbsp; is registered, but&nbsp;with very small amplitude (less than 0.5%), which cannot&nbsp; be easily&nbsp;<br />explained only by instrumental instability. When the total&nbsp;³H spectrum was measured, no significant variations in the count rate were found.&nbsp;<br />For a long time, it has been known that low-energy continuous gamma&nbsp;radiation is present in open air at the Earth&rsquo;s surface. In previous&nbsp;investigations it was assumed that this radiation is produced almost&nbsp;exclusively by gamma photons emitted due to the natural radioactivity,&nbsp;which are backscattered by air above ground.&nbsp; In the fourth experiment&nbsp;presented in this dissertation, it is&nbsp; shown&nbsp; that significant amount of this&nbsp;<br />radiation (related to energy region 30&nbsp; keV-300&nbsp; keV) that peaks at about&nbsp;90 keV, is produced by cosmic-rays, with the photon flux of about 3000&nbsp;m^-2s^-1.&nbsp; Also, it is found&nbsp; that the contribution of this omnipresent low&nbsp;energy gamma radiation of cosmic-ray origin, including the&nbsp;corresponding low-energy electron flux, to the doses of general&nbsp;<br />population are non-negligible components of overall doses induced by&nbsp;cosmic rays near sea level.</p>

<p>У докторској дисертацији&nbsp; приказани су резултати развијених и примењених коинцидентних метода за временску анализу нуклеарних процеса. Експериментални коинцидентни системи засновани су на&nbsp; HPGe&nbsp; и пластичним сцинтилационим детекторима.&nbsp; Извршена су три експеримента, која су показала примењивост развијених коинцидентних система. Први део експерименталног дела обухвата анализе временских варијација интензитета космичког зрачења посредством нискоенергијских фотона. Показано је да се праћењем интензитета нискоенергијских фотона у току времена у различитим енергијским регионима остварује бољи увид у анализу фонских догађаја, стварајући предуслове за извођење експеримената који трагају за ретким нуклеарним процесима. Поред праћења временских варијација интензитета, метода се може применити и&nbsp; на детекцију периодичних и апериодичних догађаја повезаних са активношћу Сунца. Други део дисертације обухватао је истраживања везана&nbsp; за&nbsp; детекцију потенцијалних&nbsp; флуктуација константе распада 22 Na. Развијен је коинцидентни систем&nbsp; и&nbsp; у току времена је&nbsp; праћен интензитет анихилационе линије, која је резултат анихилације позитрона емитованог распадом 22Na.&nbsp; За време трајања&nbsp; аквизиције података, нису пронађена значајна одступања испитиване константе распада од стандардног експоненцијалног закона радиоактивног распада. У трећем делу експерименталног рада, приказана је коинцидентна метода за временско раздвајање догађаја индукованих мионима и неутронима у околини детекторског система. Добијена је временска крива у експерименту и извршена је детаљна анализа различитих временских региона. Извршене су Монте Карло симулације, на основу којих је добијена временска крива. Анализом различитих региона симулиране временске криве, показано је да се ови догађаји могу раздвојити у две велике групе&ndash;брзе и споре догађаје. Међу спорим догађајима, показано је да се може направити разлика између догађаја индукованих мионима, међу којима доминира анихилација, и догађаја индукованих неутронима, који спадају у закаснеле догађаје у групи спорих догађаја. Добијено је да неутрони највише доприносе нискоенергијском региону, првенствено у региону до&nbsp; &asymp;50&nbsp; keV,&nbsp; што их чини&nbsp; нежељеном кариком фонских догађаја у експериментима који трагају за ретким нуклеарним догађајима. На основу резултата симулација, анализирани су електромагнетни и хадронски процеси индуковани мионима и неутронима, као и удели мионске и неутронске компоненте у коинцидентном спектру HPGe&nbsp; детектора и директном спектру пластичног сцинтилационог детектора. Закључено је да нискоенергијском спектру,&nbsp; који је превасходно значајан за ретке нуклеарне процесе,&nbsp; доминантно доприносе неутрони.</p> / <p>U doktorskoj disertaciji&nbsp; prikazani su rezultati razvijenih i primenjenih koincidentnih metoda za vremensku analizu nuklearnih procesa. Eksperimentalni koincidentni sistemi zasnovani su na&nbsp; HPGe&nbsp; i plastičnim scintilacionim detektorima.&nbsp; Izvršena su tri eksperimenta, koja su pokazala primenjivost razvijenih koincidentnih sistema. Prvi deo eksperimentalnog dela obuhvata analize vremenskih varijacija intenziteta kosmičkog zračenja posredstvom niskoenergijskih fotona. Pokazano je da se praćenjem intenziteta niskoenergijskih fotona u toku vremena u različitim energijskim regionima ostvaruje bolji uvid u analizu fonskih događaja, stvarajući preduslove za izvođenje eksperimenata koji tragaju za retkim nuklearnim procesima. Pored praćenja vremenskih varijacija intenziteta, metoda se može primeniti i&nbsp; na detekciju periodičnih i aperiodičnih događaja povezanih sa aktivnošću Sunca. Drugi deo disertacije obuhvatao je istraživanja vezana&nbsp; za&nbsp; detekciju potencijalnih&nbsp; fluktuacija konstante raspada 22 Na. Razvijen je koincidentni sistem&nbsp; i&nbsp; u toku vremena je&nbsp; praćen intenzitet anihilacione linije, koja je rezultat anihilacije pozitrona emitovanog raspadom 22Na.&nbsp; Za vreme trajanja&nbsp; akvizicije podataka, nisu pronađena značajna odstupanja ispitivane konstante raspada od standardnog eksponencijalnog zakona radioaktivnog raspada. U trećem delu eksperimentalnog rada, prikazana je koincidentna metoda za vremensko razdvajanje događaja indukovanih mionima i neutronima u okolini detektorskog sistema. Dobijena je vremenska kriva u eksperimentu i izvršena je detaljna analiza različitih vremenskih regiona. Izvršene su Monte Karlo simulacije, na osnovu kojih je dobijena vremenska kriva. Analizom različitih regiona simulirane vremenske krive, pokazano je da se ovi događaji mogu razdvojiti u dve velike grupe&ndash;brze i spore događaje. Među sporim događajima, pokazano je da se može napraviti razlika između događaja indukovanih mionima, među kojima dominira anihilacija, i događaja indukovanih neutronima, koji spadaju u zakasnele događaje u grupi sporih događaja. Dobijeno je da neutroni najviše doprinose niskoenergijskom regionu, prvenstveno u regionu do&nbsp; &asymp;50&nbsp; keV,&nbsp; što ih čini&nbsp; neželjenom karikom fonskih događaja u eksperimentima koji tragaju za retkim nuklearnim događajima. Na osnovu rezultata simulacija, analizirani su elektromagnetni i hadronski procesi indukovani mionima i neutronima, kao i udeli mionske i neutronske komponente u koincidentnom spektru HPGe&nbsp; detektora i direktnom spektru plastičnog scintilacionog detektora. Zaključeno je da niskoenergijskom spektru,&nbsp; koji je prevashodno značajan za retke nuklearne procese,&nbsp; dominantno doprinose neutroni.</p> / <p>In&nbsp; this&nbsp; doctoral&nbsp; thesis,&nbsp; the&nbsp; results&nbsp; of&nbsp; the&nbsp; developed and&nbsp; applied&nbsp; coincidence&nbsp;&nbsp; methods&nbsp; on&nbsp; the&nbsp; timeanalysis&nbsp; of&nbsp; nuclear&nbsp; processes&nbsp; are&nbsp; presented. Coincidence systems, used in presented experiments, are&nbsp; based&nbsp; on&nbsp; the&nbsp; HPGe&nbsp; and&nbsp; plastic&nbsp; scintillation detectors.&nbsp; Three&nbsp; experiments&nbsp; were&nbsp; performed,showing&nbsp; a&nbsp; wide&nbsp; application&nbsp; of&nbsp; the&nbsp; developed coincidence&nbsp; systems.&nbsp; The&nbsp; first&nbsp; part&nbsp; of&nbsp; the experimental work involves the analysis of the time&nbsp; variations of cosmic rays via low-energy photons. It was&nbsp; shown&nbsp; that&nbsp; by&nbsp; analyzing&nbsp; the&nbsp; intensity&nbsp; of&nbsp; lowenergy photons better insight into the behavior of thebackground&nbsp; events&nbsp; is&nbsp; provided,&nbsp; which&nbsp; is&nbsp;&nbsp; especially important&nbsp; as&nbsp; a&nbsp; precondition&nbsp; for&nbsp; rare&nbsp; nuclear&nbsp; events experiments.&nbsp; Furthermore,&nbsp; it&nbsp; was&nbsp; shown&nbsp; that&nbsp; this method can be applied in order to search for periodic or aperiodic events resulting from the Sun activity. The&nbsp; second&nbsp; part&nbsp; contains&nbsp; the&nbsp; research&nbsp; of&nbsp; the&nbsp; 22Na decay constant fluctuations. The coincidence system was&nbsp; developed&nbsp; and&nbsp; the&nbsp; intensity&nbsp; of&nbsp; the&nbsp; annihilation line,&nbsp; resulting&nbsp; from&nbsp; annihilation&nbsp; of&nbsp; the&nbsp; positrons emitted from 22Na, was followed with time. During&nbsp; he&nbsp; acquisition&nbsp; time,&nbsp; no&nbsp; significant&nbsp; deviations&nbsp; from the standard exponential radioactive decay law were found. In&nbsp; the&nbsp; third&nbsp; part&nbsp; of&nbsp; the&nbsp; experimental&nbsp; work,&nbsp; the coincidence&nbsp; method&nbsp; for&nbsp; time&nbsp; separation&nbsp; of&nbsp; the events,&nbsp; induced&nbsp; by&nbsp; cosmic&nbsp; muons&nbsp; and&nbsp; neutrons&nbsp; in the&nbsp; vicinity&nbsp; of&nbsp; the&nbsp; detectors&nbsp; system,&nbsp; was&nbsp; presented. The time curve was obtained in the experiment and the&nbsp; detailed&nbsp; analysis&nbsp; of&nbsp; the&nbsp; different&nbsp; time&nbsp; regions was&nbsp; performed.&nbsp; The&nbsp; Monte&nbsp; Carlo&nbsp; simulations&nbsp; were conducted&nbsp; and&nbsp; the&nbsp; time&nbsp; curve&nbsp; from&nbsp; the&nbsp; simulation results was obtained. Analyzing the different regions of the simulated time curve, it was noticed that these events can be separated into two groups&ndash;prompt and delayed.&nbsp; Between&nbsp; delayed&nbsp; events,&nbsp; it&nbsp; was&nbsp; concluded that&nbsp; events&nbsp; induced&nbsp; by&nbsp; muons,&nbsp; dominantly annihilation&nbsp; line,&nbsp; and&nbsp; events&nbsp; induced&nbsp; by&nbsp; neutrons, which&nbsp; may&nbsp; be&nbsp; classified&nbsp; as&nbsp; more&nbsp; delayed&nbsp; events&nbsp; in the&nbsp; group&nbsp; of&nbsp; the&nbsp; delayed&nbsp; events,&nbsp; can&nbsp; be distinguished.&nbsp; It&nbsp; was&nbsp; concluded&nbsp; the&nbsp; neutrons dominantly&nbsp; contribute&nbsp; to&nbsp; the&nbsp; low-energy&nbsp; region, mostly&nbsp; in&nbsp; the&nbsp; region&nbsp; to&nbsp; &asymp;50&nbsp; keV,&nbsp; which&nbsp; makes neutrons&nbsp; an&nbsp; important&nbsp; background&nbsp; in&nbsp; the experiments searching for rare nuclear events. Based on&nbsp; the&nbsp; simulation&nbsp; results,&nbsp; electromagnetic&nbsp; and hadronic processes induced by muons and neutrons, as&nbsp; well&nbsp; as&nbsp; portions&nbsp; of&nbsp; muon&rsquo;s&nbsp; and&nbsp; neutron&rsquo;s component&nbsp; in&nbsp; the&nbsp; coincidence&nbsp; spectrum&nbsp; of&nbsp; HPGe detector&nbsp; and&nbsp; direct&nbsp; spectrum&nbsp; of&nbsp; the&nbsp; plastic scintillation&nbsp; detector&nbsp; were&nbsp; analyzed.&nbsp; It&nbsp; was concluded&nbsp; that&nbsp; in&nbsp; the&nbsp; low-energy&nbsp; part&nbsp; of&nbsp; the spectrum,&nbsp; primarily important for the search for rare nuclear&nbsp; events,&nbsp; dominant&nbsp; influence&nbsp; is&nbsp; originated from cosmic neutrons.</p>

La radiothérapie guidée par résonance magnétique promet une administration de dose plus précise que les techniques conventionnelles puisqu’elle permet une visualisation en temps réel des structures internes avant et pendant le traitement. Cependant, la dosimétrie doit être réalisée en présence de champs magnétiques. Alors que le champ magnétique n’affecte pas le transport des particules neutres, il affecte le transport des particules chargées secondaires en raison de la force de Lorentz, qui modifie le champ de rayonnement et la réponse de dose du détecteur. Cette thèse vise à comprendre l’effet du champ magnétique sur la réponse de dose du détecteur, à la caractériser et à fournir des facteurs de correction de qualité prenant en compte l’impact du champ magnétique. Dans le premier article, quatre chambres d’ionisation à petite cavité ont été caractérisées via des simulations de Monte Carlo et des mesures expérimentales. Il a été constaté que le champ magnétique accentuait tous les détails géométriques. Une description précise du volume sensible effectif est cruciale dans les simulations. De plus, la géométrie modélisée doit être aussi proche que possible de la géométrie réelle, y compris les couches d’air internes. Des facteurs de correction de qualité tenant compte du champ magnétique et de son incertitude du budget d’incertitude sont présentés pour différentes configurations. Le deuxième article a évalué l’effet du champ magnétique sur les facteurs de perturbation de cinq détecteurs à petite cavité, dont trois détecteurs à petite cavité et deux détecteurs à semi-conducteurs. Les facteurs de perturbation des composants structurels, les facteurs de moyenne de densité et de volume ont été déterminés pour différentes tailles de champ et orientations. De plus, des facteurs de correction de qualité ont été calculés dans les mêmes conditions. Les résultats montrent que le champ magnétique a un impact significatif sur le facteur de perturbation de la densité dans les chambres d’ionisation. En revanche, son impact est plus prononcé dans les composants structurels des détecteurs semi-conducteurs. L’objectif du troisième article était de fournir plus d’informations sur la compréhension de la relation dose-réponse des détecteurs dans les champs magnétiques via des calculs de spectres de fluence électronique. La fluence des électrons différentiel en énergie dans la cavité du détecteur peut être fortement modifiée dans les champs magnétiques, et les perturbations de fluence sont généralement plus évidentes pour les électrons de faible énergie. Ces calculs ont montré l’interaction entre plusieurs facteurs qui rendent les effets de perturbation imprévisibles dans le faisceau de photons couplé aux champs magnétiques : 1) orientation du détecteur et du champ magnétique, 2) taille et forme de la cavité, 3) composants structurels, 4) couche d’air entre le détecteur et le milieu et leur asymétrie, et 5) l’énergie. / Magnetic resonance-guided radiation therapy promises more accurate dose delivery than conventional techniques by allowing real-time visualization of internal structures before and during treatment. However, the dosimetry must be performed in the presence of magnetic fields. While the magnetic field does not affect the transport of uncharged particles, it affects the transport of secondary charged particles due to the Lorentz force, which modifies the radiation field and the detector dose-response. This thesis aims to understand the effect of the magnetic field on detector dose-response, characterize it, and provide quality correction factors accounting for the impact of the magnetic field. In the first article, four small-cavity ionization chambers were characterized via Monte Carlo simulations and experimental measurements. It was found that the magnetic field emphasized all the geometrical details. An accurate description of the effective sensitive volume is crucial in the simulations. Also, the modelled geometry must be as close as possible to the actual geometry, including the internal air layers. Quality correction factors accounting for the magnetic field and its uncertainty budget uncertainty are presented for different configurations. The second article evaluated the magnetic field effect on perturbation factors of five small volume detectors, including three ionization chambers and two solid-state detectors. The perturbation factors from extracameral components, density and volume averaging factors were determined for different field sizes and orientation setups. Additionally, quality correction factors were calculated in the same conditions. Results show that the magnetic field significantly impacts the density perturbation factor in the ionization chambers. In contrast, its impact is more pronounced in the extracameral components in the solid-state detectors. The purpose of the third article was to provide more insight into the understanding of detector dose-response in magnetic fields via calculations of electron fluence spectra. The electron fluence differential in energy in the detector cavity can be severely modified in magnetic fields, and fluence perturbations are generally more evident for low-energy electrons. These calculations showed the interplay between multiple factors that make the perturbation effects unpredictable in photon beams coupled to magnetic fields: 1) detector and magnetic field orientation, 2) cavity size and shape, 3) extracameral components, 4) air gaps and their asymmetry, and 5) energy.