In daily activities, hand use is dominated by individuated thumb and finger movements, and by grasping. This thesis focused on the level of ???independence??? of the digits and its relationship to hand grasps, from the level of the motor units to the level of synergistic grasping forces. Four major studies were conducted in healthy adult volunteers. First, spike-triggered averages of forces produced by single motor units in flexor pollicis longus (FPL) in a grasp posture showed small but significant loading of the index, but not other fingers. This reflected a neural rather than anatomical coupling, as intramuscular stimulation produced minimal effect in any finger. Also, FPL had a surprisingly large number of low-force motor units and this may account for the thumb???s exceptional dexterity and force stability compared with the fingers. Second, independent control of extensor digitorum (ED) was more limited than flexor digitorum profundus (FDP), as more ED motor units of a ???test??? finger were recruited inadvertently by extension than by flexion of adjacent digits. Third, ???force enslavement??? in maximal voluntary tasks was greater in digit extension than flexion. The distribution of force enslavement (and deficits) matched the pattern of daily use of the digits (alone and in combination), and reveals a neural control system which preferentially lifts fingers together from an object by extension but allows an individual digit to flex to contact an object so the finger pads can engage in exploration and grasping. Finally, during grasping, irrespective of whether a digit had been lifted from the object, coherence among forces generated by the digits was similar. In addition, the coherence between finger forces was independent of any contraction of the thumb, was stable over 2 months, and required no learning. The pattern of coherence between digital grasping forces may be closely related to the level of digit independence and daily use. Overall, the grasp synergy was remarkably invariant over the various tasks and over time. In summary, this thesis demonstrates novel aspects of the properties of FPL, the lack of complete independence of the digits, and robustness in the production of flexion forces in hand grasps.