The Multicore Multithreaded Microprocessor maximizes parallelism on a chip for the optimal system performance, such that its popularity is growing rapidly in high-performance computing. It increases the complexity in resource distribution on a chip by leading it to two directions: isolation and unification. On one hand, multiple cores are implemented to deliver the computation and memory accessing resources to more than one thread at the same time. Nevertheless, it limits the threads’ access to resources in different cores, even if extensively demanded. On the other hand, simultaneous multithreaded architectures unify the domestic execu- tion resources together for concurrently running threads. In such an environment, threads are greatly affected by the inter-thread interference. Moreover, the impacts of the complicated distribution are enlarged by variation in workload behaviors. As a result, the microprocessor requires an adaptive management scheme to schedule threads throughout different cores and coordinate them within cores. In this study, an adaptive thread management scheme was proposed, integrating both hardware and software approaches. The instruction fetch policy at the hardware level took the responsibility by prioritizing domestic threads, while the Operating System scheduler at the software level was used to pair threads dynami- vi cally to multiple cores. The tie between them was the proposed online linear model, which was dynamically constructed for every thread based on data misses by the regression algorithm. Consequently, the hardware part of the proposed scheme proactively granted higher priority to the threads with less predicted long-latency loads, expecting they would better utilize the shared execution resources. Mean- while, the software part was invoked by such a model upon significant changes in the execution phases and paired threads with different demands to the same core to minimize competition on the chip. The proposed scheme was compared to its peer designs and overall 43% speedup was achieved by the integrated approach over the combination of two baseline policies in hardware and software, respectively. The overhead was examined carefully regarding power, area, storage and latency, as well as the relationship between the overhead and the performance.