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The effect of DHA and EPA on fibrosis-related factors in vascular cellsWhyte, Claire Susan January 2009 (has links)
Endothelial cells (ECs) and smooth muscle cell (SMC) play a key part during development of fibrosis in the intima being partly responsible for synthesis of matrix metalloproteinase (MMPs) and various regulators and substrates of these enzymes. Omega-3 (n-3) polyunsaturated fatty acids (PUFA) consumption, mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has beneficial effects on atherosclerosis but its effect on the development of fibrosis is relatively unknown. <i>Objective:</i> Determine the effects of EPA and DHA, alone or in combination, on fibrosis-related factors in aortic SMCs (AoSMCs) and human umbilical vein ECs (HUVECs) and human aortic ECs (HAECs). <i>Results:</i> Treatment of cells with/without 10 μM DHA, EPA, oleic acid (OA) or vehicle control (VC) altered expression of MMPs, regulators and substrates of MMPs and inflammatory cytokines. EPA increased the α-actin:β-actin ratio indicative of a more contractile SMC phenotype and gelatinase (MMP-2 and -9) activity in HUVECs. In aortic cells, EPA and DHA decreased uPAR mRNA and protein expressions. DHA, EPA and DHA: EPA (at 3:1 and 1:1) decreased SMC migration, this did not involve uPA/plasmin activity. <i>Conclusion:</i> EPA and DHA could decrease inflammatory cytokines and the fibrogenic environment in atherosclerotic lesions by decreasing MMP expression and activity. These fatty acids may also reduce SMC migration and proliferation, independently of uPA/plasmin activity, potentially reducing SMC build up in the intima. This could possibly prevent and/or show plaque progression and increase the stability of advanced plaques.
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Endothelium-dependent hyperpolarization and relaxation of coronary circulationg during cardioplegic arrest of the heartGe, Zhidong. January 2000 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 209-255).
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The role of runt-related transcription factor 2 in arterial smooth muscle cell mineralization /Curinga, Gabrielle Mercedes. January 2003 (has links)
Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 97-114).
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Characterization of vascular smooth muscle oxidative metabolism using ¹³C-isotopomer analysis of glutamateAllen, Tara J. January 2000 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2000. / Typescript. Vita. Includes bibliographical references (leaves 199-207). Also available on the Internet.
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Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans /Rodríguez-Lee, Mariam, January 2007 (has links)
Diss. (sammanfattning) Göteborg : Univ. , 2007. / Härtill 3 uppsatser.
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Elevated nerve growth factor in peripheral pathophysiology /Clemow, David Bice. January 1998 (has links)
Thesis (Ph. D.)--University of Virginia, 1998. / Includes bibliographical references (157-170). Also available online through Digital Dissertations.
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FGF2 is weakly mitogenic for intimal smooth muscle cells : role of FGF receptor expression, cytoplasmic signaling and cell cycle regulation /Olson, Nels Eric. January 2000 (has links)
Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 82-96).
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Calcium signaling and nerve growth factor production in pathophysiology /Sherer, Todd Benjamin. January 1999 (has links)
Thesis (Ph. D.)--University of Virginia, 1999. / Includes bibliographical references (p. 237-268). Also available online through Digital Dissertations.
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Organization of carbohydrate metabolism in vascular smooth muscleLloyd, Pamela G. January 2000 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2000. / Typescript. Vita. Includes bibliographical references (leaves 189-204). Also available on the Internet.
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The architecture of the vascular smooth muscle cells of venules in the rat intestinal microvascular bed during maturationBizuneh, Moges January 1990 (has links)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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