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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 31 to 40 of 63 (0.06 seconds)

Spelling suggestions: "subject:"nuscle, smooth, bascular"" "subject:"nuscle, smooth, ascular""

31

Role of the G protein-coupled receptor kinase 2 in mediating transforming growth factor beta and G protein-coupled receptor signaling and crosstalk mechanisms

Mancini, Johanna. January 2007 (has links)
Transforming growth factor beta (TGFbeta) and Angiotensin II (AngII) signaling occurs through two distinct receptor superfamilies, the serine/threonine kinase and G protein-coupled receptors (GPCRs). Through diametric actions, TGFbeta and AngII regulate various biological responses, including cell proliferation and migration. Previously, we identified the G protein-coupled receptor kinase 2 (GRK2), which acts through a negative feedback loop mechanism to terminate Smad signaling. To investigate the impact of TGFbeta-induced GRK2 expression on GPCR signaling, we examined its effect on AngII signaling in vascular smooth muscle cells (VSMCs). We show that activation of the TGFbeta signaling cascade results in increased GRK2 expression levels, consequently inhibiting AngII-induced ERK phosphorylation and antagonizing AngII-induced VSMC proliferation and migration. The inhibitory effect of TGFbeta on AngII signaling occurs at the MEK-ERK interface and is abrogated when an anti-sense oligonucleotide directed against GRK2 is used. Thus, we conclude that TGFbeta signaling antagonizes AngII-induced VSMC proliferation and migration through the inhibition of ERK phosphorylation. GRK2 is a key factor in mediating this crosstalk.
Muscle, Smooth, Vascular -- metabolism.
32

Development of intimal hyperplasia in transplant arteriosclerosis /

Religa, Piotr, January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
33

Perlecan in vascular disease /

Tran, Phan Kiet, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 5 uppsatser.
34

Studies of the novel PDGFs, focusing on PDGF-D /

Folestad, Erika Bergsten, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.
35

Integrin mediated mechanotransduction in renal vascular smooth muscle cells/

Balasubramanian, Lavanya. January 2007 (has links)
Dissertation (Ph.D.)--University of South Florida, 2007. / Includes vita. Includes bibliographical references (leaves 180-204). Also available online.
36

Regulation of matrix metalloproteinase-2 in vascular smooth muscle cells

Risinger, George M. January 2008 (has links) (PDF)
Thesis (Ph. D.)--University of Oklahoma. / Bibliography: leaves 153-217.
37

Role of angiotensin II in regulating smooth muscle cell replication in the vessel wall /

Su, Enming Joseph. January 1998 (has links)
Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [85]-99).
38

Coronary artery reactivity in diabetes mellitus

Dick, Gregory M. January 1996 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 1996. / Typescript. Vita. Includes bibliographical references (leaves: 106-117). Also available on the Internet.
39

Studies on leukotriene B₄ and alarmins in inflammatory responses

Wan, Min, January 2010 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2010.
40

Compartmentation of glycolysis to a plasma membrane domain : role of caveolin-1 as a scaffolding protein for phosphofructokinase /

Vallejo Rodriguez, Johana, January 2004 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2004. / "May 2004." Typescript. Vita. Includes bibliographical references (leaves 166-179). Also issued on the Internet.

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