Recent research has indicated a causal link between oxytocin and spirituality. The present experiment sought to examine the effects of intranasal oxytocin (IN-OT) and absorption on mysticism and spirituality in a sensory deprivation setting. The results failed to find any main effects of IN-OT on mysticism, or on spirituality. Interaction effects were discovered however, where IN-OT interacted with absorption both on mysticism and spirituality. More specifically IN-OT undermined the association between absorption and outcomes that were observed in the placebo control condition. The results contradict the findings from the only previous experiment conducted on IN-OT and spirituality. The interaction effects align with previous research on IN-OT, suggesting an increase in suggestibility among low absorption scorers. These results motivate further research on the relation between oxytocin, absorption and spirituality, keeping the idea of suggestibility in mind.