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1	The Comparative Performance of Micro- and Nano-topographically Complex Endosseous Implant Surfaces in Normoglycemic and Hyperglycemic Subjects Bell, Spencer 11 July 2013 (has links) Endosseous implants have notably high success rates, yet a small percentage of implants still fail for unidentified reasons. Recent literature points to hyperglycemia, resulting from untreated or undiagnosed diabetes, as a possible contraindication in an otherwise apparently healthy population. To investigate the effect of surface design on peri-implant healing in the presence of hyperglycemia, STZ-treated rats were implanted with custom rectangular implants of two surface topographies: grit blasted (GB) and grit-blast with a calcium phosphate nanotopography (GB-DCD). Tensile testing was conducted at 5, 7, and 9 days post-operative. Results demonstrated hyperglycemia to delay early stages of the peri-implant healing. Contact osteogenesis was increased along the GB-DCD surface, even in an environment of uncontrolled hyperglycemia, and the GB-DCD surface outperformed the GB surface in both healthy and hyperglycemic animals, showing peri-implant bone matured more rapidly on nanotopographically complex surfaces, even in the presence of uncontrolled hyperglycemia. Nano Surface Mechanical Testing Bone Bone-bonding Osteoconduction Contact osteogenesis de novo bone formation Implant design Titanium Calcium phosphate Hyperglycemia Diabetes Drill defect Bone healing Micro Surface Surface topography 0541

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The Comparative Performance of Micro- and Nano-topographically Complex Endosseous Implant Surfaces in Normoglycemic and Hyperglycemic Subjects